BCAR1 (NM_014567) Human Untagged Clone

CAT#: SC125332

BCAR1 (untagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BCAR1
• Synonyms: CAS; CAS1; CASS1; CRKAS; P130Cas
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC125332 sequence for NM_014567 edited (data generated by NextGen Sequencing)
  ATGAACCACCTGAACGTGCTGGCCAAAGCGCTCTATGACAATGTGGCCGAGTCCCCGGAT
  GAGCTCTCCTTCCGCAAGGGTGACATCATGACGGTGCTGGAGCAGGACACGCAGGGCCTG
  GACGGCTGGTGGCTCTGCTCGCTGCATGGGCGCCAGGGCATCGTGCCTGGGAACCGCCTC
  AAGATCTTGGTGGGCATGTATGATAAGAAGCCAGCAGGGCCTGGCTCCGGCCCTCCCGCC
  ACCCCGGCCCAGCCTCAGCCTGGCCTCCATGCCCCAGCGCCTCCGGCCTCCCAGTACACG
  CCCATGCTCCCCAACACCTACCAGCCCCAGCCAGACAGCGTCTACCTGGTGCCCACTCCC
  AGCAAGGCTCAGCAAGGCCTCTACCAAGTCCCGGGTCCCAGCCCTCAGTTCCAGTCTCCC
  CCAGCCAAGCAGACATCCACCTTCTCGAAGCAGACACCCCATCACCCGTTTCCCAGCCCG
  GCCACAGACCTGTACCAGGTGCCCCCAGGGCCTGGAGGCCCTGCCCAGGATATTTACCAG
  GTGCCACCTTCTGCCGGGATGGGGCATGACATCTACCAGGTCCCCCCGTCCATGGACACA
  CGCAGCTGGGAGGGCACGAAGCCCCCGGCAAAGGTGGTGGTGCCCACCCGCGTGGGGCAG
  GGCTATGTATACGAGGCCGCCCAGCCGGAGCAGGACGAGTACGACATCCCGCGACACCTG
  CTGGCCCCGGGGCCACAGGACATCTATGATGTGCCCCCGGTTCGGGGGCTGCTTCCCAGC
  CAGTATGGCCAGGAGGTGTATGACACACCCCCCATGGCTGTCAAGGGTCCCAATGGCCGA
  GACCCGTTGCTGGAGGTGTATGACGTGCCCCCCAGTGTGGAGAAGGGCCTGCCACCGTCC
  AATCACCACGCAGTCTACGACGTTCCTCCATCGGTGAGCAAGGATGTGCCCGATGGCCCA
  CTGCTGCGTGAGGAGACCTACGATGTGCCCCCCGCCTTCGCCAAGGCCAAGCCCTTTGAC
  CCGGCCCGCACCCCACTGGTACTGGCTGCGCCCCCTCCAGACTCCCCGCCGGCCGAGGAC
  GTGTATGACGTGCCGCCCCCGGCTCCTGACCTCTACGACGTGCCCCCTGGCTTGCGGCGG
  CCTGGCCCGGGCACCCTGTACGATGTGCCCCGTGAACGGGTGCTTCCTCCTGAGGTGGCT
  GATGGTGGCGTGGTCGACAGTGGTGTGTATGCGGTGCCTCCCCCAGCTGAACGTGAAGCC
  CCGGCAGAGGGCAAGCGCCTGTCGGCCTCCAGCACCGGCAGCACACGCAGCAGCCAGTCT
  GCGTCCTCCTTGGAGGTGGCAGGGCCGGGCCGGGAACCCCTGGAGCTGGAAGTTGCTGTG
  GAGGCCCTGGCACGGCTGCAGCAGGGTGTGAGCGCCACCGTTGCCCACCTTCTGGACCTG
  GCAGGCAGCGCCGGTGCGACTGGGAGCTGGCGTAGCCCCTCTGAGCCACAGGAGCCGCTG
  GTGCAGGACCTGCAGGCTGCTGTGGCCGCCGTCCAGAGTGCCGTCCACGAGCTGTTGGAG
  TTTGCCCGCAGCGCGGTGGGCAATGCTGCCCACACATCTGACCGTGCCCTGCATGCCAAG
  CTTAGCCGGCAGCTGCAGAAGATGGAGGACGTGCACCAGACGCTGGTGGCACATGGTCAG
  GCCCTCGACGCTGGCCGGGGAGGCTCTGGAGCCACCCTTGAGGACCTGGACCGGCTGGTG
  GCCTGCTCGCGGGCTGTGCCCGAGGACGCCAAGCAGCTGGCCTCCTTCCTGCACGGCAAT
  GCCTCACTGCTCTTCAGACGGACCAAGGCCACTGCCCCGGGGCCTGAGGGGGGTGGCACC
  CTGCACCCCAACCCCACTGACAAGACCAGCAGCATCCAGTCACGACCCCTGCCCTCACCC
  CCTAAGTTCACCTCCCAGGACTCGCCAGATGGGCAGTACGAGAACAGCGAGGGGGGCTGG
  ATGGAGGACTATGACTACGTCCACCTACAGGGGAAGGAGGAGTTTGAGAAGACCCAGAAG
  GAGCTGCTGGAAAAGGGCAGCATCACGCGGCAGGGCAAGAGCCAGCTGGAGTTGCAGCAG
  CTGAAGCAGTTTGAACGACTGGAACAGGAGGTGTCACGGCCCATAGACCACGACCTGGCC
  AACTGGACGCCAGCCCAACCCCTGGCCCCGGGGCGAACAGGCGGCCTGGGGCCCTCGGAC
  CGGCAGCTGCTGCTCTTCTACCTGGAGCAGTGTGAGGCCAACCTGACCACACTGACCAAC
  GCCGTGGACGCCTTCTTTACCGCCGTGGCCACCAACCAGCCGCCCAAGATCTTTGTGGCG
  CACAGCAAGTTCGTCATCCTCAGCGCCCACAAGCTGGTGTTCATCGGGGACACACTGTCA
  CGGCAGGCCAAGGCTGCTGACGTGCGCAGCCAGGTGACCCACTACAGCAACCTGCTGTGC
  GACCTCCTGCGCGGCATCGTGGCCACCACCAAGGCCGCTGCCTTGCAGTACCCATCGCCT
  TCCGCGGCCCAGGACATGGTGGAGAGGGTCAAGGAGCTGGGCCACAGCACCCAGCAGTTC
  CGCCGCGTCCTAGGCCAGCTGGCAGCCGCCTGA
  
  Clone variation with respect to NM_014567.3
  226 c=>t;903 c=>t;1530 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014567 unedited
  CCCCCGCCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAG
  AGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAA
  TTCGGCACGAGGCTCTGGGTGGCCGAGGCGGCAGCTGCGCGGCGGCACCGGGGCGGCTGC
  GGCGCGCTCGGAGCCCCGAGGGCACGCGGCCCGGGCAGCTCGGTGTGCGCCCCCGCGAGA
  GCCGGGGCCCCAGGCCCGCCGGACACCATGAACCACCTGAACGTGCTGGCCAAAGCGCTC
  TATGACAATGTGGCCGAGTCCCCGGATGAGCTCTCCTTCCGCAAGGGTGACATCATGACG
  GTGCTGGAGCAGGACACGCAGGGCCTGGACGGCTGGTGGCTCTGCTCGCTGCATGGGCGC
  CAGGGCATCGTGCCTGGGAACCGCCTCAAGATCTTGGTGGGCATGTATGATAAGAAGCCA
  GCAGGGCCTGGCTCCGGCCCTCCCGCCACCCCGGCCCAGCCTCAGCCTGGCCTCCATGCC
  CCAGCGCCTCCGGCCTCCCAGTACACGCCCATGCTCCCCAACACCTACCAGCCCCAGCCA
  GACAGCGTCTACCTGGTGCCCACTCCCAGCAAGGCTCAGCAAGGCCTCTACCAAGTCCCG
  GGTCCCAGCCCTCAGTTCCAGTCTCCCCCAGCCAAGCAGACATCCACCTTCTCGAAGCAG
  ACACCCCATCACCCGTTTCCCAGCCCGCCACAGACCTGTACCAGTGCCCCCAGGCCCTGN
  AGGGCCTGCCCAGGATATTACCCAGTGCCCACTCTGCCGGATGGGGCATGACTCTACCAG
  TCCCCCGTCCATGACACCGCAGCTGGAGGGCACGAACCCCGCCAAGTGGTGGTGCCACCC
  CGTGGGCAGGCTATGATACCAGCCGCCCAGCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014567 unedited
  TTTTGCCAAATTTGGACCGCGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTCCTT
  TTAAAAACTTTATTTAAATGGAGACTCTTAGTCAAATGATTGGAAAACCAATAACGAAAA
  ATAGTTCTTCAGGTTCTTCTCCTGGAAAGGCGGAGGACACACCAAACTGCACTGGCCCTG
  TCAGGGGACACGGCACCCTCGTGGGACCAGGCTCAGCCCTCGGGGTGGCACGAGGTCCTG
  CAGGCTGCAGGACCCTCACACTCCAGCCCCGTCTGGTGACCCAACCCGGGCCCGTGGTGC
  ATGCTGGAGAAGGCCACTGGCCGGCCCCTGGGCTTCGGCTCCTGAGGAGGCATGGCCCCA
  CACCCTGCCCGGCCATAAATATATACAGATTCCTGGGCATCCAGGGCACCAGGACCGACG
  CAGAGCTGGGGTCCTGTCCCTAAGCCTGTGGCACAGCGACTCTTGACATGGGAGCCAGGG
  AGCTGGGACCGCCGCACCCCTCCCCTGCCTCCCTCCTGGGGTCACCACCCTCAGGCGGCT
  GCCAGCTGGCCTAGGACGCGGCGGAACTGCTGGGTGCTGTGGCCCAGCTCCTTGACCCTC
  TCCACCATGTCCTGGGCCGCGGAAGGCGATGGGTACTGCAAGGCAGCGGCCTTGGTGGTG
  GCCACGATGCCGCGCAGGAGGTCGCACAGCAGGTTGCTGTAGTGGGTCACCTGGCTGCGC
  ACGTCAGCAGCCTTGGCCTGCCGTGACAGTGTGTCCCCGATGAACACCAGCTTGTGGGCG
  CTGAGGATGACGAACTTGCTGTGCGCCACANAGATCTTGGGCGGCTGGTTGGTGGCCACG
  GCGGTAAAGAAGGCGTCCACGGCGTTGGTCAGTGTGA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014567
• ORF Size: 2613 bp
• Insert Size: 3500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014567.2, NP_055382.2
• RefSeq Size: 3241
• RefSeq ORF: 2613
• Locus ID: 9564
• Domains: SH3, Extensin_2
• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
• Gene Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
  Transcript Variant: This variant (6) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (6) is shorter and has a different N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.