IL15RA (NM_172200) Human Untagged Clone

CAT#: SC125353

IL15RA (untagged)-Human interleukin 15 receptor, alpha (IL15RA), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL15RA
• Synonyms: CD215
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_172200, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCCGCGGCGGGCGCGCGGCTGCCGGACCCTCGGTCTCCCGGCGCTGCTACTGCTGCTGCTGCTCC
  GGCCGCCGGCGACGCGGGGCATCACGTGCCCTCCCCCCATGTCCGTGGAACACGCAGACATCTGGGTCAA
  GAGCTACAGCTTGTACTCCAGGGAGCGGTACATTTGTAACTCTGGTTTCAAGCGTAAAGCCGGCACGTCC
  AGCCTGACGGAGTGCGTGTTGAACAAGGCCACGAATGTCGCCCACTGGACAACCCCCAGTCTCAAATGCA
  TTAAGCCCGCAGCTTCATCTCCCAGCTCAAACAACACAGCGGCCACAACAGCAGCTATTGTCCCGGGCTC
  CCAGCTGATGCCTTCAAAATCACCTTCCACAGGAACCACAGAGATAAGCAGTCATGAGTCCTCCCACGGC
  ACCCCCTCTCAGACAACAGCCAAGAACTGGGAACTCACAGCATCCGCCTCCCACCAGCCGCCAGGTGTGT
  ATCCACAGGGCCACAGCGACACCACTGTGGCTATCTCCACGTCCACTGTCCTGCTGTGTGGGCTGAGCGC
  TGTGTCTCTCCTGGCATGCTACCTCAAGTCAAGGCAAACTCCCCCGCTGGCCAGCGTTGAAATGGAAGCC
  ATGGAGGCTCTGCCGGTGACTTGGGGGACCAGCAGCAGAGATGAAGACTTGGAAAACTGCTCTCACCACC
  TATGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_172200 unedited
  AATTCGGCACCAGCGGAGCAGCTGGAGGCGACCAGCGCCGGGCGAGGTCAAGTGGATCCG
  AGCCGCAGAGAGGGCTGGAGAGAGTCTGCTCTCCGATGACTTTGCCCACTCTCTTCGCAG
  TGGGGACACCGGACCGAGTGCACACTGGAGGTCCCAGAGCACGACGAGCGCGGAGGACCG
  GGAGGCTCCCGGGCTTGCGTGGGCATCACGTGCCCTCCCCCCATGTCCGTGGAACACGCA
  GACATCTGGGTCAAGAGCTACAGCTTGTACTCCAGGGAGCGGTACATTTGTAACTCTGGT
  TTCAAGCGTAAAGCCGGCACGTCCAGCCTGACGGAGTGCGTGTTGAACAAGGCCACGAAT
  GTCGCCCACTGGACAACCCCCAGTCTCAAATGCATTAGAGACCCTGCCCTGGTTCACCAA
  AGGCCAGCGCCACCCTCCACAGTAACGACGGCAGGGGTGACCCCACAGCCAGAGAGCCTC
  TCCCCTTCTGGAAAAGAGCCCGCAGCTTCATCTCCCAGCTCANACAACACAGCGGCCACA
  ACAGCAGCTATTGTCCCGGGCTCCCAGCTGATGCCTTCAAAATCACCTTCCACAGGAACC
  ACAGAGATAAGCAGTCATGAGTCCTCCCACGGGNACCCCTCTAGACNACAGCCAAGAACT
  GGGAACTCACAGCATCCGNCTTCCACCACCGGCAGGTGTGTATCACAGGGCCACAGGGAC
  ACACTGTGGTATCTCCAGGTCACTGTCCTCTTGGTGGGCTAACCCTTGTCTTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_172200 unedited
  CGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGAAAAAGATGTTTTATTTTGT
  TTATACAAGGTACAATGTCAAAATACAAATAATATATAATGTATAGATATAATAGACAAG
  GAAGTATAAATATAAACGCATATATTCGTAAAATGGCACTGAGTTGAGTTTTCTTCTTCC
  TGAATCCTTCAATGGAGAGGATTCGCTGGGCTCAGCATCTCTCCCACCTTTCCCAGGTCC
  CTGTCCATGTGTGCAGAGCAGCTGGAGACAGGGTGGTTAGAAGCCCAAACGCTGGTGTCT
  TCCCTGTAGACGTCTCCCACGCCAGGAGAAGCCTTGTAATTGCCAGAGAGCTTTGGGTAT
  GTCACTTTTCTCTGTGAACTGAAAGTTAGGATGAGGGACGGAAGATTCGGGGCAGGGTTC
  TTATTTCATTACCACATGTATTCCANGCAGCTCACACTGTAATGAAATAAAAATCCTGCT
  CAGAACCCTTTGCTCTCTCCTGAGAAGCTGGGCCCTGGGTCCAAGGCCCGACAGGCAGGC
  ANGTTGGTGCCATGGGAATGCGGAGAACCTGGTCCTTCCCCCGGGAGGCCCCATCCGTCA
  GTCGGGAAACCTGCCGGACCTTCTGACAGCCTGTGGACCTCGCCTTTGCAACCCCTCCCC
  TTCCCCTCTCCTATTTGTCTCTACTAAAGCAAAACAGTTTCCTCCCTCCCTTTTTCTCGG
  CTCCTCCCCCCTATTTTTCGGTGTTCATATTTTCCTTCCCCCATTTCCATCTCTCCTCCC
  CCCTTACCCTTTCTCCCCCACCTTGGATTCCCCCCCTCTTTTTAACTCCCCCTCCCTCCC
  ATATTCCGATTCTCCTCCCCCCCCTTTCTTCTTCCCTTCCCTCCTCACCCCCTATCACCC
  CTCGTAAACCCCTTCCCTCACCTCCCTCTATACCTCCTATTCCCCACCCTTTTCATCCTC
  CCCGTATTCATCCCCCTTATATAATTCTTTTCCTCCCGCA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_172200
• Insert Size: 1620 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_172200.1, NP_751950.1
• RefSeq Size: 1843 bp
• RefSeq ORF: 696 bp
• Locus ID: 3601
• Cytogenetics: 10p15.1
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Gene Summary: 'This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]'
  Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 4. This results in a shorter isoform (2), compared to isoform 4.