PIAS2 (NM_004671) Human Untagged Clone

CAT#: SC125358

PIAS2 (untagged)-Human protein inhibitor of activated STAT, 2 (PIAS2), transcript variant beta

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PIAS2
• Synonyms: ARIP3; DIP; MIZ1; PIASX; SIZ2; ZMIZ4
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC125358 sequence for NM_004671 edited (data generated by NextGen Sequencing)
  ATGGCGGATTTCGAAGAGTTGAGGAATATGGTTTCTAGTTTTAGGGTTTCTGAACTACAA
  GTATTACTAGGCTTTGCTGGACGGAATAAAAGTGGACGCAAGCATGACCTCCTGATGAGG
  GCGCTGCATTTATTGAAGAGCGGCTGCAGCCCTGCGGTTCAGATTAAAATCCGAGAATTG
  TATAGACGCCGATATCCACGAACTCTTGAAGGACTTTCTGATTTATCCACAATCAAATCA
  TCGGTTTTCAGTTTGGATGGTGGCTCATCACCTGTAGAACCTGACTTGGCCGTGGCTGGA
  ATCCACTCGTTGCCTTCCACTTCAGTTACACCTCACTCACCATCCTCTCCTGTTGGTTCT
  GTGCTGCTTCAAGATACTAAGCCCACATTTGAGATGCAGCAGCCATCTCCCCCAATTCCT
  CCTGTCCATCCTGATGTGCAGTTAAAAAATCTGCCCTTTTATGATGTCCTTGATGTTCTC
  ATCAAGCCCACGAGTTTAGTTCAAAGCAGTATTCAGCGATTTCAAGAGAAGTTTTTTATT
  TTTGCTTTGACACCTCAACAAGTTAGAGAGATATGCATATCCAGGGATTTTTTGCCAGGT
  GGTAGGAGAGATTATACAGTCCAAGTTCAGTTGAGACTTTGCCTGGCAGAGACAAGTTGC
  CCTCAAGAAGATAACTATCCAAATAGTCTATGTATAAAAGTAAATGGGAAGCTATTTCCT
  TTGCCTGGCTATGCACCACCGCCTAAAAATGGGATTGAACAGAAGCGCCCTGGACGCCCC
  TTGAATATTACATCTTTAGTTAGGTTATCTTCAGCTGTGCCAAACCAAATTTCCATTTCT
  TGGGCATCAGAAATTGGGAAGAATTACTCTATGTCTGTATATCTTGTACGGCAGCTTACA
  TCAGCCATGTTATTACAGAGATTAAAAATGAAAGGTATTAGAAACCCTGATCATTCCAGA
  GCACTAATTAAAGAAAAACTTACTGCAGATCCTGATAGTGAAATTGCTACAACTAGCCTT
  CGGGTATCCTTGATGTGCCCTTTAGGAAAAATGAGGCTGACAATCCCATGCCGTGCAGTG
  ACTTGTACACATCTGCAGTGTTTTGATGCTGCCCTCTATCTACAAATGAATGAGAAAAAG
  CCCACCTGGATTTGTCCTGTGTGTGACAAAAAAGCTGCCTATGAAAGTCTAATATTAGAT
  GGGCTTTTTATGGAAATTCTCAATGACTGTTCTGATGTAGATGAGATCAAATTCCAAGAA
  GATGGTTCTTGGTGTCCAATGAGACCGAAGAAAGAAGCTATGAAAGTATCCAGCCAACCG
  TGTACAAAAATAGAAAGTTCAAGCGTCCTCAGTAAGCCTTGTTCAGTGACTGTAGCCAGT
  GAGGCAAGCAAGAAGAAAGTAGATGTTATTGATCTTACAATAGAAAGCTCTTCTGACGAA
  GAGGAAGACCCTCCTGCCAAAAGGAAATGCATCTTTATGTCAGAAACACAAAGCAGCCCA
  ACCAAAGGGGTTCTCATGTATCAGCCATCTTCTGTAAGGGTGCCCAGTGTGACTTCGGTT
  GATCCTGCTGCTATTCCGCCTTCATTAACAGACTACTCAGTACCATTCCACCATACGCCA
  ATATCAAGCATGTCATCAGATTTGCCAGGTTTGGATTTTCTTTCCCTTATTCCAGTTGAT
  CCCCAGTACTGTCCTCCTATGTTTTTGGATAGTCTCACCTCACCCTTAACAGCAAGCAGT
  ACGTCTGTCACCACCACCAGCTCCCATGAAAGCAGTACTCATGTTAGTTCATCCAGCAGC
  AGGAGTGAGACAGGGGTCATAACCAGCAGTGGAAGTAACATTCCTGACATCATCTCATTG
  GACTAA
  
  Clone variation with respect to NM_004671.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004671 unedited
  TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCGGCGGCGGCCGCG
  GCGTCTTAAGCGGCGCCCAGTGCAGGATGGTGCTGGAGGCGGCGGCGGCCGTGGTGGCGG
  CAGCGTCGTTGGCGGCAGCGGGAGTGGGTGCGGCGGCAGCGGCGGCGGCGCCCGCGGGTG
  GTATAAAATGGCGGATTTCGAAGAGTTGAGGAATATGGTTTCTAGTTTTAGGGTTTCTGA
  ACTACAAGTATTACTAGGCTTTGCTGGACGGAATAAAAGTGGACGCAAGCATGACCTCCT
  GATGAGGGCGCTGCATTTATTGAAGAGCGGCTGCAGCCCTGCGGTTCAGATTAAAATCCG
  AGAATTGTATAGACGCCGATATCCACGAACTCTTGAAGGACTTTCTGATTTATCCACAAT
  CAAATCATCGGTTTTCAGTTTGGATGGTGGCTCATCACCTGTAGAACCTGACTTGGCCGT
  GGCTGGAATCCACTCGTTGCCTTCCACTTCAGTTACACCTCACTCACCATCCTCTNCTGT
  TGGTTCTGTGCTGCTTCAAGATACTAAGCCCACATTTGAGATGCAGCAGCCATCTCCCCC
  AATTCCTCCTGTCCATCCTGATGTGCAGTTAAAAAATCTGCCCTTTTATGATGTCCTTGA
  TGTTCTCATCAAGCCCACGAGTTTAGTTCANAGCAGTATTCAGCGATTTAAAGAGAAGTT
  NTTTATTNTTGCTTTGACACCTCAAACAGTTAGAGAGATATGCATATCCAGNNGATTTTT
  TGCCANNGTGGTANNGAGAGATTATACAGTCCAAGTTCAGTTGAGACTTTGCCTGGCAGA
  GACAAGTTGCCCTCAAGAAGATNACTATCCCAATAGTCTATGTATAAAAAAGTAATGGAA
  GCTATTTCCTTTGCCTGGCTATGACCCACCGCCTAAANATGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004671 unedited
  NAAAGACATTCTCATCTTGTACTTCANNTGCTCTTTATTTAACAAAACTTTTTTCACTGA
  TTTGTAGACTCCATCCATTAACGTATGAAAGTGAAATCCATCTCTCAGGAAGATACAGTT
  ATGGTTGAATGTATCTGATGCTGAGAGTACAGCATAATTAAAAAAAATCCTTGCCTGTCA
  TTTTGGTTTCTTGTTGCGAGTCTTTTGGGGTTTCCCCCTCTCAAAAAGCCAAAAAACCCC
  TTTTGGGTTTCTTTGAAATTCCCCCCCTTTTTTTAAAACAAAAAAAAAAAAAACCTTTTC
  CCCCCAGTTATTCTCCTCCCACAAAAGTCTCCTTCTTGGATAATAATTCCCCCACCACAC
  GGGGGGGCCCCCTTTCTCTCTCAAAAAAATTTTATTCGACTGGGAGAATTTTCCCCCTCT
  TTCTTTTTTTCCTACCCCTCTTCTTTTCCCCTCCCGTGTTTTTCGTTAGACAACATCCTC
  CCCCTCTTCTCTCACTTCACTCCCGCATGCTCGGCCCCGCTTATCACCGTCTTCCTTTTC
  ATTTCCGGCGGAATCGGCCCCCTTCCCCCCCCACCCGTTTTATCCCCGTCCCCCTAGTTT
  CCCCCTCTCTGTATCATGTCGGCCTCTTCTTCCCCTTCCCCCTACATTCCTATTCCCCCC
  GCTGTTCTTCCCTATATTTCACCTCCTTTTCCGTTTCCTCATCCTTTTTTCATCTTCTCT
  CCATTTCGCCTTTTGTTCTCGCCCTCGTCTCACTGTTTTCCGTCCCTTCTCTCCTTTTTC
  TACACGTGCCTACTTCCTCGTTGTCCCCACTCTCGCCCCCCTTTCTTTTCCCCTTCTTGT
  TCGTTCGGTGCCCCGCTTTTTTTTCTCCCCATGCTCCCTTTTGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004671
• ORF Size: 1866 bp
• Insert Size: 2500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004671.2, NP_004662.2
• RefSeq Size: 2360
• RefSeq ORF: 1866
• Locus ID: 9063
• Domains: SAP, zf-MIZ
• Protein Families: Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
  Transcript Variant: This variant (beta) encodes isoform (beta). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.