Calcium independent Phospholipase A2 (PLA2G6) (NM_001004426) Human Untagged Clone

CAT#: SC125777

PLA2G6 (untagged)-Human phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2


  "NM_001004426" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PLA2G6
Synonyms CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_001004426 edited
GGAAGTAGAAGTGCTGAGTAAGCCGAGACAGAGGGGGAAGACGGTGGGGCCTCCCCACCT
GCCCCGCAGAAGATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAAC
TTGTTCTCTAACCCATTCCGGGTGAAGGAGGTGGCTGTAGCCGACTACACCTCGAGTGAC
CGAGTTCGGGAGGAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGAC
TGCGTCCTGGTCAACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTG
GAGGCTGACGCCCTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAG
AGCTCCCCTCAGGTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAAC
CACCCCAGCTGGTCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCAT
CACAGCCGTATCATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTG
CACCTGGCCTGCCGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCAC
ACTCAGATGGATGTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGT
GACAATTCTCAGGTGCTGCAGCTCCTTGGAAGGAACGCAGTGGCTGGCCTGAACCAGGTG
AATAACCAAGGGCTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAGGAGATGGTC
CGCGTGCTGCTGCTGTGCAATGCTCGGTGCAACATCATGGGCCCCAACGGCTACCCCATC
CACTCGGCCATGAAGTTCTCTCAGAAGGGGTGTGCGGAGATGATCATCAGCATGGACAGC
AGCCAGATCCACAGCAAAGACCCCCGTTACGGAGCCAGCCCCCTCCACTGGGCCAAGAAC
GCAGAGATGGCCCGCATGCTGCTGAAACGGGGCTGCAACGTGAACAGCACCAGCTCCGCG
GGGAACACGGCCCTGCACGTGGCGGTGATGCGCAACCGCTTCGACTGTGCCATAGTGCTG
CTGACCCACGGGGCCAACGCGGATGCCCGCGGAGAGCACGGCAACACCCCGCTGCACCTG
GCCATGTCGAAAGACAACGTGGAGATGATCAAGGCCCTCATCGTGTTCGGAGCAGAAGTG
GACACCCCGAATGACTTTGGGGAGACTCCTACATTCCTAGCCTCCAAAATCGGCAGACAA
CTACAGGATCTCATGCACATCTCACGGGCCCGGAAGCCAGCGTTCATCCTGGGCTCCATG
AGGGACGAGAAGCGGACCCACGACCACCTGCTGTGCCTGGATGGAGGAGGAGTGAAAGGC
CTCATCATCATCCAGCTCCTCATCGCCATCGAGAAGGCCTCGGGTGTGGCCACCAAGGAC
CTGTTTGACTGGGTGGCGGGCACCAGCACTGGAGGCATCCTGGCCCTGGCCATTCTGCAC
AGTAAGTCCATGGCCTACATGCGCGGCATGTACTTTCGCATGAAGGATGAGGTGTTCCGG
GGCTCCAGGCCCTACGAGTCGGGGCCCCTGGAGGAGTTCCTGAAGCGGGAGTTTGGGGAG
CACACCAAGATGACGGACGTCAGGAAACCCAAGGTGATGCTGACAGGGACACTGTCTGAC
CGGCAGCCGGCTGAACTCCACCTCTTCCGGAACTACGATGCTCCAGAAACTGTCCGGGAG
CCTCGTTTCAACCAGAACGTTAACCTCAGGCCTCCAGCTCAGCCCTCAGACCAGCTGGTG
TGGCGGGCGGCCCGAAGCAGCGGGGCAGCTCCTACTTACTTCCGACCCAATGGGCGCTTC
CTGGACGGTGGGCTGCTGGCCAACAACCCCACGCTGGATGCCATGACCGAGATCCATGAG
TACAATCAGGACCTGATCCGCAAGGGTCAGGCCAACAAGGTGAAGAAACTCTCCATCGTT
GTCTCCCTGGGGACAGGGAGGTCCCCACAAGTGCCTGTGACCTGTGTGGATGTCTTCCGT
CCCAGCAACCCCTGGGAGCTGGCCAAGACTGTTTTTGGGGCCAAGGAACTGGGCAAGATG
GTGGTGGACTGTTGCACGGATCCAGACGGGCGGGCTGTGGACCGGGCACGGGCCTGGTGC
GAGATGGTCGGCATCCAGTACTTCAGATTGAACCCCCAGCTGGGGACGGACATCATGCTG
GATGAGGTCAGTGACACAGTGCTGGTCAACGCCCTCTGGGAGACCGAGGTCTACATCTAT
GAGCACCGCGAGGAGTTCCAGAAGCTCATCCAGCTGCTGCTCTCACCCTGAGGGTCCCCA
GCCTCTCACCGGCCCCAGCTGACCTCGTCCATTCAGCCCCTGCCAGGCCAAGCCCAGCCA
CTGCCCTCCCGGGCAGATCTGGGCCCAGGCACCTCTGAGTCCATAGACCAGGCCTGGGAG
AATGCCAAGCTGCCTGCCCGAGGCTGGTCCTGAAGGCCTGTCTCCCACTAACCCCGCCTT
CCAGCACTTTCTGTCATTCCAGGCTGGGAAAGTCTAGAGCCCCCTTTGGCCCCTTTCCCT
GACTGTCAAGGACAACTGACTCCCCCATCAGCTCAAACATTAAGGGTACCCGGGCACAAC
CGTACCCCTGCCCCCAGCCCCAGCCTCCCTGAGGGCCTGCCGGGCTGCCTCTGCCCCAGC
CCCCAGCAAGGGCACTCCCAGGCTTCCTGGTGGGTGCAGCCCACTCCCTCTGCCCTCTGC
TCCGTTCCCTGGGGGCTGGGACTAAAGAAATGGGTGTCCCCCACCCCATCAGCTGGGAAA
GCCCAGGCCGCAGGAGTGGGATGCCCGTTGGACTTTGCCCCTCACACTGGCCCAGCCCCT
CACACTGCCCCACCCCGAGAACCCTCAGCTCTCAAAGGTCACTCCTGGGAGTTTCTTCTT
CCCAATGGAAGTGGCTTAAGAGCCAAAACTGAAATAAATCATTTGGATTCAAAAAAAAAA
AAAAAAAAAAAAAAAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_001004426 unedited
NGGGGGTTTAGAATTTGTAATACGACTTACTATAGNNGGCGGCCGCGNAATTCCCGGGAT
GGAAGTAGAAGTGCTGAGTAAGCCGAGACAGAGGGGAAGACGGTGGGGCCTCCCCACCTG
CCCCGCAGAAGATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAACT
TGTTCTCTAACCCATTCCGGGTGAAGGAGGTGGCTGTAGCCGACTACACCTCGAGTGACC
GAGTTCGGGAGGAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGACT
GCGTCCTGGTCAACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTGG
AGGCTGACGCCCTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAGA
GCTCCCCTCAGGTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAACC
ACCCCAGCTGGTCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCATC
ACAGCCGTATCATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTGC
ACCTGGCCTGCCGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCACA
CTCAGATGGATGTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGTG
ACAATTCTCANGTGCTGCAGCNTCTTGGAAGGAACGCAGTGGCTGGCCTGAACCANGTGA
ATAACCAAGGGCTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAAGAGAATGTCC
GCGTGCTGCTGCTGTGCCATGCTTCGTGCAACATCC
Restriction Sites NotI-NotI     
ACCN NM_001004426
Insert Size 3100 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001004426.1, NP_001004426.1
RefSeq Size 3077 bp
RefSeq ORF 2259 bp
Locus ID 8398
Cytogenetics 22q13.1
Protein Pathways alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway
Gene Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but lacks an internal segment compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b). Isoform b is found in the cytoplasm while isoform a is membrane-bound.

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