NKG2A (KLRC1) (NM_213657) Human Untagged Clone

CAT#: SC125932

KLRC1 (untagged)-Human killer cell lectin-like receptor subfamily C, member 1 (KLRC1), transcript variant 4


  "NM_213657" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol KLRC1
Synonyms CD159A; NKG2; NKG2A
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_213657 edited
GGGGGCATGCCCCAGAGGTACAGATGTATATGTCTCCCAGGAAGTCTCTGTGGGTGAAGG
ACTGATCTCAAGTTGTGGCTGACACTAGTTAAAGCCAAGGTAGAGGGCTGTTTCAGGGTC
TACATTGAGACTACAGTTGATATGCCTACCTCCTGAGACACTAGTGTGTGAGTCTCCTCC
TGGGCCCCTGGGCAAATGGTTTTGGCAGCATGACCAAGGCCTAAATGGGGCTGAAGGCAA
GCACAGGAGGATGGGTCCCTTTTCAGGTCTGGAGATGGAATCACTGTTGCTATAGCAGGC
CTTTTTATGAGACTAACCTGGCCTCTCCACTAAAGGATGTGTGACTTTCTGGGGACAGAA
GAGTACAGTCCCTGACATCACACACTGCAGAGATGGATAACCAAGGAGTAATCTACTCAG
ACCTGAATCTGCCCCCAAACCCAAAGAGGCAGCAACGAAAACCTAAAGGCAATAAAAGCT
CCATTTTAGCAACTGAACAGGAAATAACCTATGCGGAATTAAACCTTCAAAAAGCTTCTC
AGGATTTTCAAGGGAATGACAAAACCTATCACTGCAAAGATTTACCATCAGCTCCAGAGA
AGCTCATTGTTGGGATCCTGGGAATTATCTGTCTTATCTTAATGGCCTCTGTGGTAACGA
TAGTTGTTATTCCCTCACGTCATTGTGGCCATTGTCCTGAGGAGTGGATTACATATTCCA
ACAGTTGTTACTACATTGGTAAGGAAAGAAGAACTTGGGAAGAGAGTTTGCTGGCCTGTA
CTTCGAAGAACTCCAGTCTGCTTTCTATAGATAATGAAGAAGAAATGAAATTTCTGTCCA
TCATTTCACCATCCTCATGGATTGGTGTGTTTCGTAACAGCAGTCATCATCCATGGGTGA
CAATGAATGGTTTGGCTTTCAAACATGAGATAAAAGACTCAGATAATGCTGAACTTAACT
GTGCAGTGCTACAAGTAAATCGACTTAAATCAGCCCAGTGTGGATCTTCAATAATATATC
ATTGTAAGCATAAGCTTTAGAGGTAAAGCGTTTGCATTTGCAGTGCATCAGATAAATTGT
ATATTTCTTAAAATAGAAATATATTATGATTGCATAAATCTTAAAATGAATTATGTTATT
TGCTCTAATAAGAAAATTCTAAATCAATTATTGAAACAGGATACACACAATTACTAAAGT
ACAGACATCCTAGCATTTGTGTCGGGCTCATTTTGCTCAACATGGTATTTGTGGTTTTCA
GCCTTTCTAAAAGTTGCATGTTATGTGAGTCAGCTTATAGGAAGTACCAAGAACAGTCAA
ACCCATGGAGACAGAAAGTAGAATAGTGGTTGCCAATGTCTGAGGGAGGTTGAAATAGGA
GATGACCTCTAACTGATAGAACGTTACTTTGTGTCGTGATGAAAACTTTCTAAATTTCAG
TAGTGGTGATGGTTGTAACTCTGCGAATATACTAAACATCATTGATTTTTAATCATTTTA
AGTGCATGAAATGTATGCTTTGTACATGACACTTCAATAAAGCTATCCACAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_213657 unedited
GGTCAGGAATTTGTATACGACTCACTATAGGCGGCGCGCGAATTCGCCATTACGGCCGGG
GGCATGCCCCAGAGGTACAGATGTGTATGTCTCCCAGGAAGTCTCTGTGGGTGAAGGACT
GATCTCAAGTTGTGGCTGACACTAGTTAAAGCCAAGGTAGAGGGCTGTTTCAGGGTCTAC
ATTGAGACTACAGTTGATATGCCTACCTCCTGAGACACTAGTGTGTGAGTCTCCTCCTGG
GCCCCTGGGCAAATGGTTTTGGCAGCATGACCAAGGCCTAAATGGGGCTGAAGGCAAGCA
CAGGAGGATGGGTCCCTTTTCAGGTGTGGAGATGGAATCACTGTTGCTATAGCAGGCCTT
TTTATGAGACTAACCTGGCCTCTCCACTAAAGGATGTGTGACTTTCTGGGGACAGAAGAG
TACAGTCCCTGACATCACACACTGCAGAGATGGATAACCAAGGAGTAATCTACTCAGACC
TGAATCTGCCCCCAAACCCAAAGAGGCAGCAACGAAAACCTAAAGGCAATAAAAGCTCCA
TTTTAGCAACTGAACAGGAAATAACCTATGCGGAATTAAACCTTCAAAAAGCTTCTCAGG
AGTTTCAAGGGAATGACAAAACCTATCACTGCGAAGATTTACCATCAGCTCCAAAGAAGC
TCATTGTTGGGATCCTGGGAATTATCTGTCTTATCTTAATGGCCTCTGTGGTAACGATAG
TTGTTATTCCCTCACGTCATTGTGGCCATTGTGCTGAGGAGTGGATTACATATTCCAACA
GTTGTTACTACATTGGGAAGAAAGAANAACTGGGAAGAAGATTTGCTGGCCTGTACTCCA
AGAACTCCAGTCTGCTTTCTATAGATAATGAAAAAGAAATGAAATTTCTGGCATCATTTT
ACCATCCTGATGGAGTGGGGGTGTTTCCTAACAGCAGTCATCATCGCTGGG
Restriction Sites Please inquire     
ACCN NM_213657
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_213657.1, NP_998822.1
RefSeq Size 1332 bp
RefSeq ORF 648 bp
Locus ID 3821
Cytogenetics 12p13.2
Protein Families Transmembrane
Protein Pathways Antigen processing and presentation, Graft-versus-host disease, Natural killer cell mediated cytotoxicity
Gene Summary 'Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]'
Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding exon compared to variant 1. The resulting isoform (NKG2-B) is shorter compared to isoform NKG2-A. Variants 2 and 4 encode the same isoform (NKG2-B).

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