GDF 5 (GDF5) (NM_000557) Human Untagged Clone

CAT#: SC125956

GDF5 (untagged)-Human growth differentiation factor 5 (GDF5)


  "NM_000557" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GDF5
Synonyms BDA1C; BMP-14; BMP14; CDMP1; DUPANS; LAP-4; LAP4; OS5; SYM1B; SYNS2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_000557 edited
CGCTGCCACTGGTTAGCGATAATACTGGCAGCGCGACCGGTTTCTGAGGGTTGTTCACCT
TGCTGCTCAGACGCTCCGAGAAGCTTCAGGCAGCATAACACTTACAGTAGAGACAGGGTT
TCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCT
CCCAAGGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCTGGCCGCAATTTACTTCATTGA
ATCTCCAACAAGAGTCCTGTGAGCTGCTGACTGGAGACGGTGCACGTCTGGATACGAGAG
CATTTCCACTATGGGACTGGATACAAACACACACCCGGCAGACTTCAAGAGTCTCAGACT
GAGGAGAAAGCCTTTCCTTCTGCTGCTACTGCTGCTGCCGCTGCTTTTGAAAGTCCACTC
CTTTCATGGTTTTTCCTGCCAAACCAGAGGCACCTTTGCTGCTGCCGCTGTTCTCTTTGG
TGTCATTCAGCGGCTGGCCAGAGGATGAGACTCCCCAAACTCCTCACTTTCTTGCTTTGG
TACCTGGCTTGGCTGGACCTGGAATTCATCTGCACTGTGTTGGGTGCCCCTGACTTGGGC
CAGAGACCCCAGGGGACCAGGCCAGGATTGGCCAAAGCAGAGGCCAAGGAGAGGCCCCCC
CTGGCCCGGAACGTCTTCAGGCCAGGGGGTCACAGCTATGGTGGGGGGGCCACCAATGCC
AATGCCAGGGCAAAGGGAGGCACCGGGCAGACAGGAGGCCTGACACAGCCCAAGAAGGAT
GAACCCAAAAAGCTGCCCCCCAGACCGGGCGGCCCTGAACCCAAGCCAGGACACCCTCCC
CAAACAAGGCAGGCTACAGCCCGGACTGTGACCCCAAAAGGACAGCTTCCCGGAGGCAAG
GCACCCCCAAAAGCAGGATCTGTCCCCAGCTCCTTCCTGCTGAAGAAGGCCAGGGAGCCC
GGGCCCCCACGAGAGCCCAAGGAGCCGTTTCGCCCACCCCCCATCACACCCCACGAGTAC
ATGCTCTCGCTGTACAGGACGCTGTCCGATGCTGACAGAAAGGGAGGCAACAGCAGCGTG
AAGTTGGAGGCTGGCCTGGCCAACACCATCACCAGCTTTATTGACAAAGGGCAAGATGAC
CGAGGTCCCGTGGTCAGGAAGCAGAGGTACGTGTTTGACATTAGTGCCCTGGAGAAGGAT
GGGCTGCTGGGGGCCGAGCTGCGGATCTTGCGGAAGAAGCCCTCGGACACGGCCAAGCCA
GCGGCCCCCGGAGGCGGGCGGGCTGCCCAGCTGAAGCTGTCCAGCTGCCCCAGCGGCCGG
CAGCCGGCCTCCTTGCTGGATGTGCGCTCCGTGCCAGGCCTGGACGGATCTGGCTGGGAG
GTGTTCGACATCTGGAAGCTCTTCCGAAACTTTAAGAACTCGGCCCAGCTGTGCCTGGAG
CTGGAGGCCTGGGAACGGGGCAGGGCCGTGGACCTCCGTGGCCTGGGCTTCGACCGCGCC
GCCCGGCAGGTCCACGAGAAGGCCCTGTTCCTGGTGTTTGGCCGCACCAAGAAACGGGAC
CTGTTCTTTAATGAGATTAAGGCCCGCTCTGGCCAGGACGATAAGACCGTGTATGAGTAC
CTGTTCAGCCAGCGGCGAAAACGGCGGGCCCCACTGGCCACTCGCCAGGGCAAGCGACCC
AGCAAGAACCTTAAGGCTCGCTGCAGTCGGAAGGCACTGCATGTCAACTTCAAGGACATG
GGCTGGGACGACTGGATCATCGCACCCCTTGAGTACGAGGCTTTCCACTGCGAGGGGCTG
TGCGAGTTCCCATTGCGCTCCCACCTGGAGCCCACGAATCATGCAGTCATCCAGACCCTG
ATGAACTCCATGGACCCCGAGTCCACACCACCCACCTGCTGTGTTCCCACGCGGCTGAGT
CCCATCAGCATCCTCTTCATTGACTCTGCCAACAACGTGGTGTATAAGCAGTATGAGGAC
ATGGTCGTGGAGTCGTGTGGCTGCAGGTAGCAGCACTGGCCCTCTGTCTTCCTGGGTGGC
ACATCCCAAGAGCCCCTTCCTGCACTCCTGGAATCACAGAGGGGTCAGGAAGCTGTGGCA
GGAGCATCTACACAGCTTGGGTGAAAGGGGATTCCAATAAGCTTGCTCGCTCTCTGAGTG
TGACTTGGGCTAAAGGCCCCCTTTTATCCACAAGTTCCCCTGGCTGAGGATTGCTGCCCG
TCTGCTGATGTGACCAGTGGCAGGCACAGGTCCAGGGAGACAGACTCTGAATGGGACTGA
GTCCCAGGAAACAGTGCTTTCCGATGAGACTCAGCCCACCATTTCTCCTCACCTGGGCCT
TCTCAGCCTCTGGACTCTCCTAAGCACCTCTCAGGAGAGCCACAGGTGCCACTGCCTCCT
CAAATCACATTTGTGCCTGGTGACTTCCTGTCCCTGGGACAGTTGAGAAGCTGACTGGGC
AAGAGTGGGAGAGAAGAGGAGAGGGCTTGGATAGAGTTGAGGAGTGTGAGGCTGTTAGAC
TGTTAGATTTAAATGTATATTGATGAGATAAAAAGCAAAACTGTGCCTAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA
>OriGene 5' read for NM_000557 unedited
CATATTTGTATACGACTCACTATAGGCGGCCGCGTAATCAGATCTGGTACCGGTCCGGAA
TTCCCGGGATCGCTGCCACTGGTTAGCGATAATACTGGCAGCGCGACCGGTTTCTGAGGG
TTGTTCACCTTGCTGCTCAGACGCTCCGAGAAGCTTCAGGCAGCATAACACTTACAGTAG
AGACAGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCACCT
GCCTCGGCCTCCCAAGGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCTGGCCGCAATTT
ACTTCATTGAATCTCCAACAAGAGTCCTGTGAGCTGCTGACTGGAGACGGTGCACGTCTG
GATACGAGAGCATTTCCACTATGGGACTGGATACAAACACACACCCGGCAGACTTCAAGA
GTCTCAGACTGAGGAGAAAGCCTTTCCTTCTGCTGCTACTGCTGCTGCCGCTGCTTTTGA
AAGTCCACTCCTTTCATGGTTTTTCCTGCCAAACCAGAGGCACCTTTGCTGCTGCCGCTG
TTCTCTTTGGTGTCATTCAGCGGCTGGCCAGAGGATGAGACTCCCCAAACTCCTCACTTT
CTTGCTTTGGTACCTGGCTTGGCTGGACCTGGAATTCATCTGCACTGTGTTTGGGTGCCC
CTGATTTGGGCCAAAGACCCCAGGGGACAGGCCAGGATTGGCCCAAACAGAGGCCAAGGA
GAGGCCCCCCTGGGCCCGGAACGTCATCAGGCCGGGGGGTCAAACCTGGGGGGGGGGGCC
ACCAAGCCAATGCCGGGGAAAGGGGGACCCGGGACAAACAGGGGCCTGACACCCCCAAAA
GAGAGAACCAACAAGAGGCGCCCAAAAAGGGAGGGCCCGAAACCCAGCAGGAACCCCTCC
CCTAACAAGGCGGGTACAAGCAAAGGAGAGGACCCAAAAGGAAGCTT
Restriction Sites Please inquire     
ACCN NM_000557
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000557.2, NP_000548.1
RefSeq Size 2383 bp
RefSeq ORF 1506 bp
Locus ID 8200
Cytogenetics 20q11.22
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
Gene Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

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