HOGA1 (NM_138413) Human Untagged Clone

CAT#: SC125992

HOGA1 (untagged)-Human 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), nuclear gene encoding mitochondrial protein, transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: HOGA1
• Synonyms: C10orf65; DHDPS2; DHDPSL; HP3; NPL2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_138413 edited
  AGTGCTGGGAATTGTGGGAGGAGGGCCCAGATCCCACTGGAGATACCGAAGGAGATACTC
  TTTAGTATTGGGATCCCAGAAACCAGTCCTATATCTGGCCAGAGGGACACTGGGTTGTGG
  CATCTCTCTAGCTGCTACCGAGAAGGAACAGGGCCCCCTGGGGCCTATAGGCCTTGCCCC
  TGACCCTGGGAACACGCAGCTCAGGCCTGCCCCAGTGGCCACAAGTCAGGGAGGCCGCAA
  ATTTTTAACTAGAAACATTGATCATTAATAGGGGGTTAGAAAGAGTTCAAACTAAGTCTC
  ACTCTGGGACATAGACCAATTGTGCTTCAGGCCTCCTGCAGAGATGCTGGGTCCCCAAGT
  CTGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGC
  CTCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTT
  CACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAATCTGCACAAACTGGGCAC
  CTTCCCCTTCCGAGGCTTCGTGGTCCAGGGCTCCAATGGCGAGTTTCCTTTCCTGACCAG
  CAGTGAGCGCCTCGAGGTGGTGAGCCGTGTGCGCCAGGCCATGCCCAAGAACAGGCTCCT
  GCTAGCTGGCTCCGGATGCGAGTCCACTCAAGCCACAGTGGAGATGACCGTCAGCATGGC
  CCAGGTCGGGGCTGACGCGGCCATGGTGGTGACCCCTTGCTACTATCGTGGCCGCATGAG
  CAGTGCGGCCCTCATTCACCACTACACCAAGGTTGCTGATCTCTCTCCAATCCCTGTGGT
  GCTGTACAGTGTCCCAGCCAACACAGGGCTGGACCTGCCTGTGGATGCAGTGGTCACGCT
  TTCCCAGCACCCGAATATTGTGGGCATGAAGGACAGCGGTGGTGATGTGACCAGGATTGG
  GCTGATTGTTCACAAGACCAGGAAGCAGGATTTTCAGGTGTTGGCTGGATCGGCTGGCTT
  TCTGATGGCCAGCTATGCCTTGGGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCT
  GGGGGCTCAGGTGTGCCAGCTGGAGCGACTGTGCTGCACGGGGCAATGGGAAGATGCCCA
  GAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGGTGACCCGGCGCTTTGGGATCCC
  AGGGCTGAAGAAAATCATGGACTGGTTTGGCTACTATGGAGGCCCCTGCCGCGCACCCTT
  GCAGGAGCTGAGCCCCGCTGAGGAGGAGGCACTGCGCATGGATTTCACCAGCAACGGCTG
  GCTCTGAGGGCAGGCAGGGTCCATGGCTGGCCTGAGCCCATCTCAGCCTCCTGCCTTGCA
  CTTGCAGCCTGAAGCGGAGAGCACAGGGGGATGAGGGTGGCAGGCAGCGGGGAGCCGATA
  GAGGCTCCTTTGCCTGCTGTGGTCCTCCAGGCAGCCTTTCACAGGCACGCCCATGCATAT
  CTCCTATTCTAACGGCCCCTGACCTCTCCCTTTTGGATCCTAAACTGTGTCTCTGGTCTG
  AAGACTGGGAAGGAGCAATTTCTCAATTTATCTTTCTACTGTGGATGCTTTCCTACGCCC
  TGAGGCACATGAAGTCAGAAAGGAAGGGCAGAGGGGCAAGTAGGCACAGTAAGGGAATTT
  TCTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTTTCACTCTGTCACCCAGGCTGGAGTGC
  AATGGCATGATCTCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGC
  TGGGATTACAGGCGCCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGG
  GTTTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCAACTGCCTC
  GGCCTCCCAAAGTGCTGGGATTACAGCTGTGAGCCACTGCACCCGGCCGGGAATTTATCA
  AAGGGGGGACTACTTAGATTTGGGGCTTCAAACCTGAGTCTAGCACAATGCAGCTGGAGG
  CCAGGGCTACTCCTACAAACCCAAGTTCTGACTCCTTCCAGGGAAGTATCAGCTTAAGAA
  ACTTGATCAGGAAAGTGACACTGGTCTTTCAAAGAGCCCTCTTTACCCTCCCATCCCTGC
  CCTCTACACTGCAAGCTGCATTCCAGCCACAACGCCCTTTTCTAAATCTATTTTCATTCA
  TCTCCTATTCTGGTCTGTAGCCTTGATTCCAACCATTGAATGCACGGAGACAGCCCAGTG
  GCTTGTCAGATTGGTAAATAATGACACCTGGTGGATAAATGTTACATTCTAGAAGACTAT
  TCTGGTCAGCCTAGGTCTGAAACACTAAGGAGACTTGGCCTGAGATAGGGCCATCCACTT
  GCCTACAGGCACTCTGCTTTTATTATTAAAAATAGTCACTTTGTTACTATAATAAAATTT
  AACAGAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_138413 unedited
  GGCGGTGTTTAGGATATTTGTCAATACGCACTTCACTGTGAGGGNCGGACCGCATAACTT
  CGTATAGCATACATTATACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGT
  CGAGAGCGGATTGCGGGAGGAGGGCCCAGATCCCACTGGAGATACCGAAGGAGATACTCT
  TTAGTATTGGGATCCCAGAAACCAGTCCTATATCTGGCCAGAGGGACACTGGGTTGTGGC
  ATCTCTCTAGCTGCTACCCAGAAGGAACAGGGCCCCCTGGGGCCTATAGGCCTTGCCCCT
  GACCCTGGGAACACCCAGCTCAGGCCTGCCCCAGTGGCCACAAGTCAGGGAGGCCGCAAA
  TTTTTAACTAGAAACATTGATCATTAATAGGGGGTTAGAAAGAGTTCAAACTAAGTCTCA
  CTCTGGGACATAGACCAATTGTGCTTCAGGCCTCCTGCAGAGATGCTGGGTCCCCAAGTC
  TGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCC
  TCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTTC
  ACTGCCACTGCATAGGTGGACTATGGGAAACTGGAGGAAAATCTGCACAAACTGGGCACC
  TTTCCCTTCCGAGGAGCTGTGGGGGGCGTCTGCGCCCCTGCCAATGGCCTGGGGGCTCAG
  GTATCCCAGCTGGAACCACTGGTCTTCCACGGGCATTGGGAAGAGCCCAGAAACTGCTAT
  ATCGCCTTATTGAACAAACGCTGCTTTAACCCCGCCCTTTTGGATCCCAGGCTGTAAAAA
  AACTGGACCGGTTTGGCTCATTGGAGGCTCTGGGCCCCCTCTTGCAGGATTGACCCCG
  
• Restriction Sites: Please inquire
• ACCN: NM_138413
• ORF Size: 984 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_138413.2, NP_612422.2
• RefSeq Size: 2480
• RefSeq ORF: 984
• Locus ID: 112817
• Gene Summary: The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).