APLP2 (BC004371) Human Untagged Clone

CAT#: SC126161

APLP2 (untagged)-Human amyloid beta (A4) precursor-like protein 2, mRNA (cDNA clone MGC:10449 IMAGE:3640033), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: APLP2
• Synonyms: amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; APPH; APPL2; CDEBP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC004371 edited
  GCTAAGCGAGGAGTCTGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAG
  GGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGC
  TGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCA
  ATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAA
  ATATGCATGTGAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCT
  GCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGA
  TCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACA
  AAAAGCAATGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTTCCTCCAACTCCTC
  TGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTC
  GCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAA
  AGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGCAGA
  CTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGA
  AGCAGCAGCTGGTGGAGACCCACCTGGCCCGAGTGGAAGCTATGCTGAATGACCGCCGTC
  GGATGGCTCTGGAGAACTACCTGGCTGCCTTGCAGTCTGACCCGCCACGGCCTCATCGCA
  TTCTCCAGGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCC
  GTCATTACCAGCACGTGTTGGCTGTTGACCCAGAAAAGGCGGCCCAGATGAAATCCCAGG
  TGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAACCCTCTCTCTGCTCTACA
  AAGTACCTTATGTAGCCCAAGAAATTCAAGAGGAAATTGATGAGCTCCTTCAGGAGCAGC
  GTGCAGATATGGACCAGTTCACTGCCTCAATCTCAGAGACCCCTGTGGACGTCCGGGTGA
  GCTCTGAGGAGAGTGAGGAGATCCCACCGTTCCACCCCTTCCACCCCTTCCCAGCCCTAC
  CTGAGAACGAAGGATCTGGAGTGGGAGAGCAGGATGGGGGACTGATCGGTGCCGAAGAGA
  AAGTGATTAACAGTAAGAATAAAGTGGATGAAAACATGGTCATTGACGAGACTCTGGATG
  TTAAGGAAATGATTTTCAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCG
  TGGGCCCACTGCGGGAGGACTTCAGTCTGAGTAGCAGTGCTCTCATTGGCCTGCTGGTCA
  TCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGGAAGAGGCAGT
  ATGGCACCATCAGCCACGGGATCGTGGAGGTTGATCCAATGCTCACCCCAGAAGAGCGTC
  ACCTGAACAAGATGCAGAACCATGGCTATGAGAACCCCACCTACAAATACCTGGAGCAGA
  TGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGGTGGGCCGGAA
  GATCCCACGATTCCGATCGACTGCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTGACAT
  CCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCAATTTCCATTC
  TTTTAAATGGGTGAAAAATGGTAATATAACAATATATGATATATAAAAAAAAAAAAAAAA
  AA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC004371 unedited
  GTTCAGATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGCTAAGCGAG
  GAGTCTGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGC
  CACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCT
  CACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCCGGAAC
  AGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGT
  GAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAAC
  AAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACAAATGT
  GATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATG
  CAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTTCCTCCAACTCCTCTGCCAACCAA
  TGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAA
  GGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATG
  GGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCAAAGCAGAGAGGCAGACTCTGATTCAG
  CACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGAAGCAGCAGCTG
  GTGGAGACCCANCTGGCCCGAGTGGAAGCTATGCTGAATGACCCCGCGTCGATGGCTCTG
  GAGAACTACCTGGCTGCCNTTGCAGTCTGACCGCCACGGCCTCATCGCATTCTNNCAGCC
  TTNACNGCGTAATGTCCGTGCTGAGAACAAAGATCGCTTACTTACATTCGTA
  
• Restriction Sites: Please inquire
• ACCN: BC004371
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC004371.1, AAH04371.1
• RefSeq Size: 1862 bp
• RefSeq ORF: 1566 bp
• Locus ID: 334
• Cytogenetics: 11q24.3
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: 'This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]'