PRSS2 (NM_002770) Human Untagged Clone

CAT#: SC126235

PRSS2 (untagged)-Human protease, serine, 2 (trypsin 2) (PRSS2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PRSS2
• Synonyms: TRY2; TRY8; TRYP2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002770 edited
  CATGAATCTACTTCTGATCCTTACCTTTGTTGCAGCTGCTGTTGCTGCCCCCTTTGATGA
  TGATGACAAGATCGTTGGGGGCTACATCTGTGAGGAGAATTCTGTCCCCTACCAGGTGTC
  CTTGAATTCTGGCTACCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTGTC
  AGCAGGTCACTGCTACAAGTCCCGCATCCAGGTGAGACTGGGAGAGCACAACATCGAAGT
  CCTGGAGGGGAATGAACAGTTCATCAATGCGGCCAAGATCATCCGCCACCCCAAATACAA
  CAGCCGGACTCTGGACAATGACATCCTGCTGATCAAGCTCTCCTCACCTGCCGTCATCAA
  TTCCCGCGTGTCCGCCATCTCTCTGCCCACTGCCCCTCCAGCTGCTGGCACCGAGTCCCT
  CATCTCCGGCTGGGGCAACACTCTGAGTTCTGGTGCCGACTACCCAGACGAGCTGCAGTG
  CCTGGATGCTCCTGTGCTGAGCCAGGCTGAGTGTGAAGCCTCCTACCCTGGAAAGATTAC
  CAACAACATGTTCTGTGTGGGCTTCCTCGAGGGAGGCAAGGATTCCTGCCAGGGTGATTC
  TGGTGGCCCTGTGGTCTCCAATGGAGAGCTCCAAGGAATTGTCTCCTGGGGCTATGGCTG
  TGCCCAGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTTA
  GGACACCATAGCTGCCAACAGCTAAAGCCCCTGGTCCCTCTGCAGTCTCTATACCAATAA
  AGTGACCCTGCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAT
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002770 unedited
  TTCAGATTTTGTAATACGACTTACTATAGGGCGGACCGCGAATCAGATCTGGTACCGGTC
  CGGAATTCCCGGGATCATGAATCTACTTCTGATCCTTAACTTTGTTGCAGCTGCTGTTGC
  TGCCCCCTTTGATGATGATGACAAGATCGTTGGGGGCTACATCTGTGAGGAGAATTCTGT
  CCCCTACCAGGTGTCCTTGAATTCTGGCTACCACTTCTGCGGTGGCTCCCTCATCAGCGA
  ACAGTGGGTGGTGTCAGCAGGTCACTGCTACAAGTCCCGCATCCAGGTGAGACTGGGAGA
  GCACAACATCGAAGTCCTGGAGGGGAATGAACAGTTCATCAATGCGGCCAAGATCATCCG
  CCACCCCAAATACAACAGCCGGACTCTGGACAATGACATCCTGCTGATCAAGCTCTCCTC
  ACCTGCCGTCATCAATTCCCGCGTGTCCGCCATCTCTCTGCCCACTGCCCCTCCAGCTGC
  TGGCACCGAGTCCCTCATCTCCGGCTGGGGCAACACTCTGAGTTCTGGTGCCGACTACCC
  AGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAGGCTGAGTGTGAAGCCTCCTA
  CCCTGGAAAGATTACCAACAACATGTTCTGTGTGGGCTTCCTCGAGGGAGGCAAGGATTC
  CTGCCAGGGTGATTCTGGTGGCCCCTGTGTCTCNCATGGAGAGCTCCAAGAATTGTCTCC
  CTGGGCTATGGCTGTGCCCAGAAGAACAGGCCTGGAGTCTACACCANGGTCTACAACTAT
  GTGGACTGGATTTANGACACCATAGCTGCCCACAGCTAAAGCCCCTGGTCCCTCTGCAGT
  CTCTATACCATAAAGTGACCCTGCTCTCAAAAAAAAAAANAANNNNAAAAAAAAAAAAAA
  AAAAATTTNNAAAAAAAAAAAAAAANAAAAAAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002770
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002770.2, NP_002761.1
• RefSeq Size: 802 bp
• RefSeq ORF: 744 bp
• Locus ID: 5645
• Cytogenetics: 7q34
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Neuroactive ligand-receptor interaction
• Gene Summary: 'This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]'
  Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.