PAK4 (NM_001014833) Human Untagged Clone

CAT#: SC126377

PAK4 (untagged)-Human p21(CDKN1A)-activated kinase 4 (PAK4), transcript variant 6

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAK4
• Synonyms: p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001014833 edited
  GGGGATTCAACATGGCGGCGGGAGTGTCCGCGGTGGTGGCGGTGCAAGAGAGCTGAAGGA
  GGCGCGAGGGCGCGGAGTTCCAGGCCGAGCAGTTAGGCCGCGAGCGACTGCGGCGCCGAG
  CCGATGAGTAACCCGAAGCCCCTAGAGGAGTGGTCACCTGCCTGAGGGCACTTCTGTCCC
  ACCAGCATCAGACCAGGCCGCACCGAGTCCCCGGCACCATGTTTGGGAAGAGGAAGAAGC
  GGGTGGAGATCTCCGCGCCGTCCAACTTCGAGCACCGCGTGCACACGGGCTTCGACCAGC
  ACGAGCAGAAGTTCACGGGGCTGCCCCGCCAGTGGCAGAGCCTGATCGAGGAGTCGGCTC
  GCCGGCCCAAGCCCCTCGTCGACCCCGCCTGCATCACCTCCATCCAGCCCGGGGCCCCCA
  AGACCATCGTGCGGGGCAGCAAAGGTGCCAAAGATGGGGCCCTCACGCTGCTGCTGGACG
  AGTTTGAGAACATGTCGGTGACACGCTCCAACTCCCTGCGGAGAGACAGCCCGCCGCCGC
  CCGCCCGTGCCCGCCAGGAAAATGGGATGCCAGAAAAGCCCCCTGGCCCCCGCTCACCAC
  AGCGGGAGCCACAGCGAGTATCCCATGAGCAGTTCCGGGCTGCCCTGCAGCTGGTGGTGG
  ACCCAGGCGACCCCCGCTCCTACCTGGACAACTTCATCAAGATTGGCGAGGGCTCCACGG
  GCATCGTGTGCATCGCCACCGTGCGCAGCTCGGGCAAGCTGGTGGCCGTCAAGAAGATGG
  ACCTGCGCAAGCAGCAGAGGCGCGAGCTGCTCTTCAACGAGGTGGTAATCATGAGGGACT
  ACCAGCACGAGAATGTGGTGGAGATGTACAACAGCTACCTGGTGGGGGACGAGCTCTGGG
  TGGTCATGGAGTTCCTGGAAGGAGGCGCCCTCACCGACATCGTCACCCACACCAGGATGA
  ACGAGGAGCAGATCGCGGCCGTGTGCCTTGCAGTGCTGCAGGCCCTGTCGGTGCTCCACG
  CCCAGGGCGTCATCCACCGGGACATCAAGAGCGACTCGATCCTGCTGACCCATGATGGCA
  GGGTGAAGCTGTCAGACTTTGGGTTCTGCGCCCAGGTGAGCAAGGAAGTGCCCCGAAGGA
  AGTCGCTGGTCGGCACGCCCTACTGGATGGCCCCAGAGCTCATCTCCCGCCTTCCCTACG
  GGCCAGAGGTAGACATCTGGTCGCTGGGGATAATGGTGATTGAGATGGTGGACGGAGAGC
  CCCCCTACTTCAACGAGCCACCCCTCAAAGCCATGAAGATGATTCGGGACAACCTGCCAC
  CCCGACTGAAGAACCTGCACAAGGTGTCGCCATCCCTGAAGGGCTTCCTGGACCGCCTGC
  TGGTGCGAGACCCTGCCCAGCGGGCCACGGCAGCCGAGCTGCTGAAGCACCCATTCCTGG
  CCAAGGCAGGGCCGCCTGCCAGCATCGTGCCCCTCATGCGCCAGAACCGCACCAGATGAG
  GCCCAGCGCCCTTCCCCTCAACCAAAGAGCCCCCCGGGTCACCCCCGCCCCACTGAGGCC
  AGTAGGGGGCCAGGCCTCCCACTCCTCCCAGCCCGGGAGATGCTCCGCGTGGCACCACCC
  TCCTTGCTGGGGGTAGATGAGACCCTACTACTGAACTCCAGTTTTGATCTCGTGACTTTT
  AGAAAAACACAGGGACTCGTGGGAGCAAGCGAGGCTCCCAGGACCCCCACCCTCTGGGAC
  AGGCCCTCCCCCATGTTCTTCTGTCTCCAGGAAGGGCAGCGGCCCTCCCATCACTGGAAG
  TCTGCAGTGGGGGTCGCTGGGGGTGGAGAGAACACTAAGAGGTGAACATGTATGAGTGTG
  TGCACGCGTGTGAGTGTGCATGTGTGTGTGTGTGCAAAGGTCCAGCCACCCCGTCCTCCA
  GCCCGCAAGGGGTGTCTGGCGCCTTGCCTGACACCCAGCCCCCTCTCCCCCTGAGCCATT
  GTGGGGGTCGATCATGAATGTCCGAAGAGTGGCCTTTTCCCGTAGCCCTGCGCCCCCTTT
  CTGTGGCTGGATGGGGAGACAGGTCAGGGCCCCCCACCCTCTCCAGCCCCTGCAGCAAAT
  GACTACTGCACCTGGACAGCCTCCTCTTTTCTAGAAGTCTATTTATATTGTCATTTTATA
  ACACTCTAGCCCCTGCCCTTATTGGGGGACAGATGGTCCCTGTCCTGCGGGGTGGCCCTG
  GCAGAACCACTGCCTGAAGAACCAGGTTCCTGCCCGGTCAGCGCAGCCCCAGCCCGCCCA
  CCCCTGCCTCGAGTTAGTTTTACAATTAAAACATTGTCTTGTAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001014833 unedited
  NNGGTAGACGTTTAGGATTTGTNATACGACTTACTATAGGCGGCCGCGTAATCAAATCTG
  GTACCGGTCCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGTTCAACATGGCGGCGG
  GAGTGTCCGCGGTGGTGGCGGTGCAAGAGAGCTGAAGGAGGCGCGAGGGCGCGGAGTTCC
  AGGCCGAGCAGTTAGGCCGCGAGCGACTGCGGCGCCGAGCCGGCCGCACCGAGTCCCCGG
  CACCATGTTTGGGAAGAGGAAGAAGCGGGTGGAGATCTCCGCGCCGTCCAACTTCGAGCA
  CCGCGTGCACACGGGCTTCGACCAGCACGAGCAGAAGTTCACGGGGCTGCCCCGCCAGTG
  GCAGAGCCTGATCGAGGAGTCGGCTCGCCGGCCCAAGCCCCTCGTCGACCCCGCCTGCAT
  CACCTCCATCCAGCCCGGGGCCCCCAAGACCATCGTGCGGGGCAGCAAAGGTGCCAAAGA
  TGGGGCCCTCACGCTGCTGCTGGACGAGTTTGAGAACATGTCGGTGACACGCTCCAACTC
  CCTGCGGAGAGACAGCCCGCCGCCGCCCGCCCGTGCCCGCCAGGAAAATGGGATGCCAGA
  GGAGCCGGCCACCACGGCCAGAGGGGGCCCAGGGAATGCAGGCAGCCGAGGCCGGTTCGC
  CGGTCACAGCGAGTCTTTTGGCGGCAATGGTGACAGGTTATGGNCGGGCCATATAAGAGG
  CCCAAGTCTTCCAGTGAGGGCTCACGGGGTTCCCCAGTAGTCCTCGCGGGATAACGCGTC
  CTCTTCGGGCCTGATTTCGGCACCCCCTTACTTGTTTGGTTTGGCCAGTGGGGCAAAACC
  GGCGCTTGTGCGGTCCTTAAAACC
  
• Restriction Sites: Please inquire
• ACCN: NM_001014833
• ORF Size: 2346 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001014833.1, NP_001014833.1
• RefSeq Size: 2346
• RefSeq ORF: 2346
• Locus ID: 10298
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Axon guidance, ErbB signaling pathway, Focal adhesion, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway
• Gene Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (6) lacks an in-frame segment in the coding region, as compared to variant 1. The encoded isoform (3) thus lacks an internal segment, as compared to isoform 1.