NALP2 (NLRP2) (BC001039) Human Untagged Clone

CAT#: SC126446

NLRP2 (untagged)-Human NACHT, leucine rich repeat and PYD containing 2, mRNA (cDNA clone MGC:1031 IMAGE:3504594), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NLRP2
• Synonyms: CLR19.9; FLJ20510; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NALP2; NBS1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing; PAN1; PYPAF2; PYRIN-Containing APAF1-like
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC001039 edited
  GGGAGCTCCCACGTGGGACAAGATGGTGTCTTCGGCGCAGATGGGCTTCAACCTGCAGGC
  TCTCCTGGAGCAGCTCAGCCAGGATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTT
  CTCCCTGGCACACGAGCTCCAGAAGATCCCCCACAAGGAGGTAGACAAGGCTGATGGGAA
  GCAACTGGTAGAAATCCTCACCACCCATTGTGACAGCTACTGGGTGGAGATGGCGAGCCT
  CCAGGTCTTTGAAAAGATGCACCGAATGGATCTGTCTGAGAGAGCAAAGGATGAAGTCAG
  AGAAGCAGCTTTGAAATCCTTTAATAAAAGGAAGCCTCTATCATTAGGGATAACACGGAA
  AGAACGACCACCTCTAGACGTGGACGAAATGCTGGAGCGCTTCAAAACAGAAGCACAAGC
  GTTTACAGAAACGAAAGGAAATGTCATCTGCCTGGGTAAAGAAGTCTTTAAAGGAAAAAA
  GCCAGACAAAGACAATAGGTGCAGGTATATATTGAAGACGAAGTTCCGGGAGATGTGGAA
  GAGCTGGCCTGGAGATAGCAAAGAGGTCCAGGTTATGGCTGAGAGATACAAGATGCTGAT
  CCCATTCAGCAACCCCAGGGTGCTTCCCGGGCCCTTCTCATACACGGTGGTGCTGTATGG
  TCCTGCAGGCCTTGGGAAAACCACGCTGGCCCAGAAACTAATGCTAGACTGGGCAGAGGA
  CAACCTCATCCACAAATTCAAATATGCGTTCTACCTCAGCTGCAGGGAGCTCAGCCGCCT
  GGGCCCGTGCAGTTTTGCAGAGCTGGTCTTCAGGGACTGGCCTGAATTGCAGGATGACAT
  TCCACACATCCTAGCCCAAGCACGGAAAATCTTGTTCGTGATTGACGGCTTTGATGAGCT
  GGGAGCCGCACCTGGGGCGCTGATCGAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCC
  GGTGCCCGTCCTCCTGGGGAGTTTGCTGAACAGGGTGATGTTACCCAAGGCCGCCCTGCT
  GGTCACCACGCGGCCCAGGGCCCTGAGGGACCTCCGGATCCTGGCGGAGGAGCCGATCTA
  CATAAGGGTGGAGGGCTTCCTGGAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGG
  AGACGAGGACCAAGCCATGCGTGCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCA
  GCTGGGCTCGGCCCCCGCGGTGTGCTGGATCGTGTGCACGACTCTGAAGCTGCAGATGGA
  GAAGGGGGAGGACCCGGTCCCCACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCT
  CTGCAGCCGGTTCCCGCAGGGCGCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCT
  GGCCGCGCAGGGCCTGTGGGCGCAGACGTCCGTGCTTCACCGAGAGGATCTGGAAAGGCT
  CGGGGTGCAGGAGTCCGACCTCCGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAG
  AGTCTCCAAAGGCTGCTACTCCTTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCT
  GTTCTACACCCTGGAGAAGGAGGAGGAAGAGGATAGGGACGGCCACACCTGGGACATTGG
  GGACGTACAGAAGCTGCTTTCCGGAGTAGAAAGACTCAGGAACCCCGACCTGATCCAAGC
  AGGCTACTACTCCTTTGGCCTCGCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTT
  TGGCTGCCGGATGTCACCGGACATCAAACAGGAATTGCTGCGATGCGACATAAGTTGTAA
  GGGTGGACATTCAACGGTGACAGACCTGCAGGAGCTGCTCGGCTGTCTGTACGAGTCTCA
  GGAGGAGGAGCTGGTGAAGGAGGTGATGGCTCAGTTCAAAGAAATATCCCTGCACTTAAA
  TGCAGTAGACGTTGTGCCATCTTCATTCTGCGTCAAGCACTGTCGAAACCTGCAGAAAAT
  GTCACTGCAGGTAATAAAGGAGAATCTCCCGGAGAATGTCACTGCGTCTGAATCAGACGC
  CGAGGTTGAGAGATCCCAGGATGATCAGCACATGCTTCCTTTCTGGACGGACCTTTGTTC
  CATATTTGGATCAAATAAGGATCTGATGGGTCTAGCAATCAATGATAGCTTTCTCAGTGC
  CTCCCTAGTAAGGATCCTGTGTGAACAAATAGCCTCTGACACCTGTCATCTCCAGAGAGT
  GGTGTTCAAAAACATTTCCCCAGCTGATGCTCATCGGAACCTCTGCCTAGCTCTTCGAGG
  TCACAAGACTGTAACGTATCTGACCCTTCAAGGCAATGACCAGGATGATATGTTTCCCGC
  ATTGTGTGAGGTCTTGAGACATCCAGAATGTAACCTGCGATATCTCGGGTTGGTGTCTTG
  TTCCGCTACCACTCAGCAGTGGGCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCT
  GACGTGCGTAAACCTCTCCGACAATGAGCTTCTGGATGAGGGTGCTAAGTTGCTGTACAC
  AACTTTGAGACACCCCAAGTGCTTTCTGCAGAGGTTGTCGTTGGAAAACTGTCACCTTAC
  AGAAGCCAATTGCAAGGACCTTGCTGCTGTGTTGGTTGTCAGCCGGGAGCTGACACACCT
  GTGCTTGGCCAAGAACCCCATTGGGAATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAG
  GTACCCCGAGTGTAAACTGCAGACCTTGGTGCTTTGGAACTGCGACATAACTAGCGATGG
  CTGCTGCGATCTCACAAAGCTTCTCCAAGAAAAATCAAGCCTGTTGTGTTTGGATCTGGG
  GCTGAATCACATAGGAGTTAAGGGAATGAAGTTCCTGTGTGAGGCTTTGAGGAAACCACT
  GTGCAACTTGAGATGTCTGTGGTTGTGGGGATGTTCCATCCCTCCGTTCAGTTGTGAAGA
  CCTCTGCTCTGCCCTCAGCTGCAACCAGAGCCTCGTCACTCTGGACCTGGGTCAGAATCC
  CTTGGGGTCTAGTGGAGTGAAGATGCTGTTTGAAACCTTGACATGTTCCAGTGGCACCCT
  CCGGACACTCAGGTTGAAAATAGATGACTTTAATGATGAACTCAATAAGCTGCTGGAAGA
  AATAGAAGAAAAAAACCCACAACTGATTATTGATACTGAGAAACATCATCCCTGGGAAGA
  AAGGCCTTCTTCTCATGACTTCATGATCTGAATCCCCCCGAGTCATTCATTCTCCATGAA
  GTCATCGATTTTCCAGGTGTGGGTGAACTGCCTGTGACTCCTCTCCTCCCCCGCCCCTAC
  CCCTCAGGGATAATGAGTTCATTGCTGGGCTAGATGTTTTAGCCATGATTCTGCCTCTGT
  TTTATACCTGCACACATCCTTATCTTTGTTACATATGAAATATCTGTATCACGGGTATAT
  TGAGAGAAATAAAGGTGAGAGCATTCAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC001039 unedited
  CCCCGCCCGTTCAGGCATATTTGTNAATACGNACTTCATNATNAGGGCGGCCGCGCAATT
  CGCACNGGGGGAGCTCCCAGTGGGACAAGATGGTGTCTTCGGCGCAGATGGGCTTCAACC
  TGCAGGCTCTCCTGGAGCAGCTCAGCCAGGATGAGTTGAGCAAGTTCAAGTATCTGATCA
  CGACCTTCTCCCTGGCACACGAGCTCCAGAAGATCCCCCACAAGGAGGTAGACAAGGCTG
  ATGGGAAGCAACTGGTAGAAATCCTCACCACCCATTGTGACAGCTACTGGGTGGAGATGG
  CGAGCCTCCAGGTCTTTGAAAAGATGCACCGAATGGATCTGTCTGAGAGAGCAAAGGATG
  AAGTCAGAGAAGCAGCTTTGAAATCCTTTAATAAAAGGAAGCCTCTATCATTAGGGATAA
  CACGGAAAGAACGACCACCTCTAGACGTGGACGAAATGCTGGAGCGCTTCAAAACAGAAG
  CACAAGCGTTTACAGAAACGAAAGGAAATGTCATCTGCCTGGGTAAAGAAGTCTTTAAAG
  GAAAAAAGCCAGACAAAGACAATAGGTGCAGGTATATATTGAAGACGAAGTTCCGGGAGA
  TGTGGAAGAGCTGGCCTGGAGATAGCAAAGAGGTCCAGGTTATGGCTGAGAGATACAAGA
  TGCTGATCCCATTCAGCAACCCCAGGGTGCTTCCCGGGCCCTTCTCATACACGGTGGTGC
  TGTATGGTCCTGCAGGCCTTGGGAAACCACGCTGGCCCANGAACTAATGCTAGACTGGGC
  AGAGGGACACCTCATCCACAAATTCAAATATGCCGTCTACCTCAGCTGCAGGGAGCTCAG
  CCGCCTGGGCCCCGTGCAGTTTTGCAGAGCTGGGTCTTCAGGGACTGGCCTGAATTGCAG
  GATGACATTC
  
• Restriction Sites: Please inquire
• ACCN: BC001039
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC001039.2, AAH01039.1
• RefSeq Size: 3465
• Locus ID: 55655
• Gene Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]