SIGLEC8 (BC053319) Human Untagged Clone

CAT#: SC126463

SIGLEC8 (untagged)-Human sialic acid binding Ig-like lectin 8 (cDNA clone MGC:59785 IMAGE:6302572), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SIGLEC8
• Synonyms: SIGLEC8L
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC053319 edited
  GAAGAACCCTGAGGAACAGACGTTCCCTGGCGGCCCTGGCGCCTTCAAACCCAGACATGC
  TGCTGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGACAAAGGGGATGGAGGGAGACAGAC
  AATATGGGGATGGTTACTTGCTGCAAGTGCAGGAGCTGGTGACGGTGCAGGAGGGCCTGT
  GTGTCCATGTGCCCTGCTCCTTCTCCTACCCCCAGGATGGCTGGACTGACTCTGACCCAG
  TTCATGGCTACTGGTTCCGGGCAGGAGACAGACCATACCAAGACGCTCCAGTGGCCACAA
  ACAACCCAGACAGAGAAGTGCAGGCAGAGACCCAGGGCCGATTCCAACTCCTTGGGGACA
  TTTGGAGCAACGACTGCTCCCTGAGCATCAGAGACGCCAGGAAGAGGGATAAGGGGTCAT
  ATTTCTTTCGGCTAGAGAGAGGAAGCATGAAATGGAGTTACAAATCACAGTTGAATTACA
  AAACTAAGCAGCTGTCTGTGTTTGTGACAGCCCTGACCCATAGGCCTGACATCCTCATCC
  TAGGGACCCTAGAGTCTGGCCACCCCAGGAACCTGACCTGCTCTGTGCCCTGGGCCTGTA
  AGCAGGGGACACCCCCCATGATCTCCTGGATTGGGGCCTCCGTGTCCTCCCCGGGCCCCA
  CTACTGCCCGCTCCTCAGTGCTCACCCTTACCCCAAAGCCCCAGGACCACGGCACCAGCC
  TCACCTGTCAGGTGACCTTGCCTGGGACAGGTGTGACCACGACCAGTACCGTCCGCCTCG
  ATGTGTCCTACCCTCCTTGGAACTTGACCATGACTGTCTTCCAAGGAGATGCCACAGCAT
  CCACAGCCCTGGGAAATGGCTCATCTCTTTCAGTCCTTGAGGGCCAGTCTCTGCGCCTGG
  TCTGTGCTGTCAACAGCAATCCCCCTGCCAGGCTGAGCTGGACCCGGGGGAGCCTGACCC
  TGTGCCCCTCACGGTCCTCAAACCCTGGGCTGCTGGAGCTGCCTCGAGTGCACGTGAGGG
  ATGAAGGGGAATTCACCTGCCGAGCTCAGAACGCTCAGGGCTCCCAGCACATTTCCCTGA
  GCCTCTCCCTGCAGAATGAGGGCACAGGCACCTCAAGACCTGTATCACAAGTGACACTGG
  CAGCAGTCGGGGGAGCTGGAGCCACAGCCCTGGCCTTCCTGTCCTTCTGCATCATCTTCA
  TCATAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGGCGTGGGGGATACAG
  GCATGGAAGATGCAAAGGCCATCAGGGGCTCGGCCTCTCAGGGACCCCTGACTGAATCCT
  GGAAAGATGGCAACCCCCTGAAGAAGCCTCCCCCAGCTGTTGCCCCCTCGTCAGGGGAGG
  AAGGAGAGCTCCATTATGCAACCCTCAGCTTCCATAAAGTGAAGCCTCAGGACCCGCAGG
  GACAGGAGGCCACTGACAGTGAATACTCGGAGATCAAGATCCACAAGCGAGAAACTGCAG
  AGACTCAGGCCTGTTTGAGGAATCACAACCCCTCCAGCAAAGAAGTCAGAGGCTGATTCT
  CATAGAACAAGAACCCTCTAGAGCCCCATGCTATGCAGTAGGTCACCAGGGCTCCCTCCT
  CCTGTCTAACCAAAACTTGGACCAATGTCTCCCCTTTCCCCGGCTACCAGGGACCCATCC
  CTGCCTCTAGCTTCTACTACCCACCATTCTCCTCTCGACCTCTCTGAGGTTGACTATTTT
  AGATTCCACATAGAGATGAGGTCATGTGGTACTTGCCTCTCTGTGTGTGGCTCATTTTAC
  ACAAAAAAATATCCCCTAGGTTCATCCATGTTCTCTCAAATGACAGAATCAAGCACTGAA
  TATTTTTTTTTCTTTGAGAGATGGAGTTTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGT
  TCAATCTCTGCTCACTGCAACCTCCACCTCCTGGGTTCAAACGATTCTCCTGCCTCAGCT
  TCCCAAGTAGCTGGTACTACAGGCGTGTGTCACCACGCCCAGCTAATTTTTGTATTTTTT
  AGTAGAGACGGGGTTTCACTATAAGTGGGCCAGGCTAGTCTCAAACTCCTGACCTCAAGT
  GATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTTCAGGCATGAGCCACCGCACCCAG
  CTTGCATTGAATATTTTCAAGGAGCTAAAAGAAGATTTTAAATGGTCTCACAAAAACAGA
  TAAATATTTGCACAGATGGGTGTGCTAATCATTGTGCCTTGATGGTTCCACGATGTATCC
  GGGTGTGGAAATCTCACTGGGTCTCTCTCAAGGCCACTCGGCTACTCAGGACAGGGCTGG
  AATTTAAAGCCTGTCCGATTCTGAGGTCTCTTCTCTCATCTAGCACTGAGTCAAGCAATC
  AGCAGGCTGGGCACCCCTTAGCCATAAGTTTTCAGGAAATAAATTCCTTGAGGGCATTGA
  CTTTTACAAAAGAGGGAGCAGCAATGGCCTAGAGTCTCAGGAACAAGACAGGTGCACTGA
  GGAGATGAAGGCCGGGACCCCCTGCCCAACCTGTATGGCGGGTCTGTACTTATTTTGTTT
  ACCCCCAATTTAAAACGTTTTTTTTTATTGCAGGTTGTTTGTTTGATATGGTTTGGCTGT
  GTCCCCACCCAAATCTTATCTAGAATTGTAATCAGAATTATAATCCCCATGTGTTGGGGG
  AGGGACCTGGTGGGAGGTGATAGGATCATGGGGGTGGTTCCCCCATGCTGTTCTGATAGT
  GAGTGAGTTATCACGAGATCTGATGGTTTTGTAAGTGGTGGTTTCCCCTGCTCTTCTCTC
  TTGCCTGCCACCATGTAAGATGTGCCTGGTTCCCCTTCCGCCATGATTGTAAGTTTCCTG
  AGGCCTCCTCCGCCATGTGGAACTGTGAGTCAATTACACCTCTTTCATTTATAAATTAAA
  AAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014442 unedited
  NGCCGTTCAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGNAAG
  AACCCTGAGGAACAGACGTTCCCTGGCGGCCCTGGCGCCTTCAAACCCAGACATGCTGCT
  GCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGACAAAGGGGATGGAGGGAGACAGACAATA
  TGGGGATGGTTACTTGCTGCAAGTGCAGGAGCTGGTGACGGTGCAGGAGGGCCTGTGTGT
  CCATGTGCCCTGCTCCTTCTCCTACCCCCAGGATGGCTGGACTGACTCTGACCCAGTTCA
  TGGCTACTGGTTCCGGGCAGGAGACAGACCATACCAAGACGCTCCAGTGGCCACAAACAA
  CCCAGACAGAGAAGTGCAGGCAGAGACCCAGGGCCGATTCCAACTCCTTGGGGACATTTG
  GAGCAACGACTGCTCCCTGAGCATCAGAGACGCCAGGAAGAGGGATAAGGGGTCATATTT
  CTTTCGGCTAGAGAGAGGAAGCATGAAATGGAGTTACAAATCACAGTTGAATTACAAAAC
  TAAGCAGCTGTCTGTGTTTGTGACAGCCCTGACCCATAGGCCTGACATCCTCATCCTAGG
  GACCCTAGAGTCTGGCCACCCCAGGAACCTGACCTGCTCTGTGCCCTGNGCCTGTAAGCA
  GGGGACACCCCCCATGATCTCCTGGATTGGGGCCTCCGTGTCCTCCCCGGGCCCCACTAC
  TGCCCGCTCCTCAGTGCTCACCCTTACCCCAAAGCCCCAGGACCACGGCACCAGCCTCAC
  CTGTCANGTGACCTTGCCTGGGACAGGTGTGACCACGACCAGTACCGTCCGCCTCGATGT
  GTCCTACCCCTCTTGAACTTGACCATGACTGTCTTCCAAGGAGATGCCCAGCATCCACAG
  CCCTG
  
• Restriction Sites: Please inquire
• ACCN: BC053319
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC053319.1, AAH53319.1
• RefSeq Size: 2956
• Locus ID: 27181
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]). [supplied by OMIM, May 2010]