Neurotrypsin (PRSS12) (NM_003619) Human Untagged Clone

CAT#: SC126501

PRSS12 (untagged)-Human protease, serine, 12 (neurotrypsin, motopsin) (PRSS12)


  "NM_003619" in other vectors (6)

Reconstitution Protocol

USD 1,780.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PRSS12
Synonyms BSSP-3; BSSP3; MRT1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_003619, the custom clone sequence may differ by one or more nucleotides


ATGACGCTCGCCCGCTTCGTGCTAGCCCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTG
TCCTCAATGATTCCCTCCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCT
TCCCACCCAGCAGCGGCCCCCGAGGACGCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCCGCGG
GCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCCCCGGCCGCACCCCTGGGGCTGCC
CCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTGTCTGCGGTGGGCGGAGGTGCCACC
CTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCAGCTGCGAGGACAGCGCCACAACTTTTGTCGGAGC
CCCGACGGCGCGGGCAGACCCTGGTGTTTCTACGGAGACGCCCGTGGCAAGGTGGACTGGGGCTACTGCG
ACTGCAGACACGGATCAGTACGACTTCGTGGCGGCAAAAATGAGTTTGAAGGCACAGTGGAAGTATATGC
AAGTGGAGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGTCATTTGTCACCAG
CTGCAGCTGGGAGGAAAAGGAATAGCAAAACAAACCCCGTTTTCTGGACTGGGCCTTATTCCCATTTATT
GGAGCAATGTCCGTTGCCGAGGAGATGAAGAAAATATACTGCTTTGTGAAAAAGACATCTGGCAGGGTGG
GGTGTGTCCTCAGAAGATGGCAGCTGCTGTCACGTGTAGCTTTTCCCATGGCCCAACGTTCCCCATCATT
CGCCTTGCTGGAGGCAGCAGTGTGCATGAAGGCCGGGTGGAGCTCTACCATGCTGGCCAGTGGGGAACCG
TTTGTGATGACCAATGGGATGATGCCGATGCAGAAGTGATCTGCAGGCAGCTGGGCCTCAGTGGCATTGC
CAAAGCATGGCATCAGGCATATTTTGGGGAAGGGTCTGGCCCAGTTATGTTGGATGAAGTACGCTGCACT
GGGAATGAGCTTTCAATTGAGCAGTGTCCAAAGAGCTCCTGGGGAGAGCATAACTGTGGCCATAAAGAAG
ATGCTGGAGTGTCCTGTACCCCTCTAACAGATGGGGTCATCAGACTTGCAGGTGGGAAAGGCAGCCATGA
GGGTCGCTTGGAGGTATATTACAGAGGCCAGTGGGGAACTGTCTGTGATGATGGCTGGACTGAGCTGAAT
ACATACGTGGTTTGTCGACAATTGGGATTTAAATATGGTAAACAAGCATCTGCCAACCATTTTGAAGAAA
GCACAGGGCCCATATGGTTGGATGACGTCAGCTGCTCAGGAAAGGAAACCAGATTTCTTCAGTGTTCCAG
GCGACAGTGGGGAAGGCATGACTGCAGCCACCGCGAAGATGTTAGCATTGCCTGCTACCCTGGCGGCGAG
GGACACAGGCTCTCTCTGGGTTTTCCTGTCAGACTGATGGATGGAGAAAATAAGAAAGAAGGACGAGTGG
AGGTTTTTATCAATGGCCAGTGGGGAACAATCTGTGATGATGGATGGACTGATAAGGATGCAGCTGTGAT
CTGTCGTCAGCTTGGCTACAAGGGTCCTGCCAGAGCAAGAACCATGGCTTACTTTGGAGAAGGAAAAGGA
CCCATCCATGTGGATAATGTGAAGTGCACAGGAAATGAGAGGTCCTTGGCTGACTGTATCAAGCAAGATA
TTGGAAGACACAACTGCCGCCACAGTGAAGATGCAGGAGTTATTTGTGATTATTTTGGCAAGAAGGCCTC
AGGTAACAGTAATAAAGAGTCCCTCTCATCTGTTTGTGGCTTGAGATTACTGCACCGTCGGCAGAAGCGG
ATCATTGGTGGGAAAAATTCTTTAAGGGGTGGTTGGCCTTGGCAGGTTTCCCTCCGGCTGAAGTCATCCC
ATGGAGATGGCAGGCTCCTCTGCGGGGCTACGCTCCTGAGTAGCTGCTGGGTCCTCACAGCAGCACACTG
TTTCAAGAGGTATGGCAACAGCACTAGGAGCTATGCTGTTAGGGTTGGAGATTATCATACTCTGGTACCA
GAGGAGTTTGAGGAAGAAATTGGAGTTCAACAGATTGTGATTCATCGGGAGTATCGACCCGACCGCAGTG
ATTATGACATAGCCCTGGTTAGATTACAAGGACCAGAAGAGCAATGTGCCAGATTCAGCAGCCATGTTTT
GCCAGCCTGTTTACCACTCTGGAGAGAGAGGCCACAGAAAACAGCATCCAACTGTTACATAACAGGATGG
GGTGACACAGGACGAGCCTATTCAAGAACACTACAACAAGCAGCCATTCCCTTACTTCCTAAAAGGTTTT
GTGAAGAACGTTATAAGGGTCGGTTTACAGGGAGAATGCTTTGTGCTGGAAACCTCCATGAACACAAACG
CGTGGACAGCTGCCAGGGAGACAGCGGAGGACCACTCATGTGTGAACGGCCCGGAGAGAGCTGGGTGGTG
TATGGGGTGACCTCCTGGGGGTATGGCTGTGGAGTCAAGGATTCTCCTGGTGTTTATACCAAAGTCTCAG
CCTTTGTACCTTGGATAAAAAGTGTCACCAAACTGTAA


>OriGene 5' read for NM_003619 unedited
GGCCGCGAAATTCGCACGAGGCCGCCCCCTCCTCTTCTCCGCTCCAAGCCCGAGAAGCTG
GGGAGCATGGACCAGACCCCGCAGCGCTGGCACCATGACGCTCGCCCGCTTCGTGCTAGC
CCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTGTCCTCAATGATTCCCT
CCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCTTCCCAC
CCAGCAGCGGCCCCCGACGACGCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCC
GCGGGCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCCCCGGCCGCA
CCCCTGGGGCTGCCCCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTG
TCTGCGGTGGGCGGAGGTGCCACCCTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCA
GCTGCGAGGACAGCGCCACAACTTTTGTCGGAGCCCCGACGGCGCGGGCAGACCCTTGGT
GTTTCTACGGAGACGCCCGTGGCAAGGGTGGACTGGGGCTACTGCGACTGCAGACACGGA
TCAGTACGACTTCGTGGCGGCAAAAATGAGTTTGAAGGCACAGTGGAAGTATATGCAAGT
GGGAGGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGTCATTT
GTCACCAGCTGCAGCTGGGGAGGAAAAGGAATAGCAANACAACCCCGTTTTCTGGACTGG
GCCTTATTCCATTTATTGGAGCCATGTCCCGTGCCGAGGAGATGAGAAAAATACTGCTTT
GTGAAAAGACTCTGCAGGGGNGGG
Restriction Sites NotI-NotI     
ACCN NM_003619
ORF Size 2628 bp
Insert Size 3410
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_003619.2, NP_003610.1
RefSeq Size 4573
RefSeq ORF 2628
Locus ID 8492
Domains KR, SR, Tryp_SPc
Protein Families Druggable Genome, Protease, Secreted Protein
Gene Summary This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]

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