Neurotrypsin (PRSS12) (NM_003619) Human Untagged Clone

CAT#: SC126501

PRSS12 (untagged)-Human protease, serine, 12 (neurotrypsin, motopsin) (PRSS12)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PRSS12
• Synonyms: BSSP-3; BSSP3; MRT1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_003619, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACGCTCGCCCGCTTCGTGCTAGCCCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTG
  TCCTCAATGATTCCCTCCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCT
  TCCCACCCAGCAGCGGCCCCCGAGGACGCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCCGCGG
  GCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCCCCGGCCGCACCCCTGGGGCTGCC
  CCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTGTCTGCGGTGGGCGGAGGTGCCACC
  CTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCAGCTGCGAGGACAGCGCCACAACTTTTGTCGGAGC
  CCCGACGGCGCGGGCAGACCCTGGTGTTTCTACGGAGACGCCCGTGGCAAGGTGGACTGGGGCTACTGCG
  ACTGCAGACACGGATCAGTACGACTTCGTGGCGGCAAAAATGAGTTTGAAGGCACAGTGGAAGTATATGC
  AAGTGGAGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGTCATTTGTCACCAG
  CTGCAGCTGGGAGGAAAAGGAATAGCAAAACAAACCCCGTTTTCTGGACTGGGCCTTATTCCCATTTATT
  GGAGCAATGTCCGTTGCCGAGGAGATGAAGAAAATATACTGCTTTGTGAAAAAGACATCTGGCAGGGTGG
  GGTGTGTCCTCAGAAGATGGCAGCTGCTGTCACGTGTAGCTTTTCCCATGGCCCAACGTTCCCCATCATT
  CGCCTTGCTGGAGGCAGCAGTGTGCATGAAGGCCGGGTGGAGCTCTACCATGCTGGCCAGTGGGGAACCG
  TTTGTGATGACCAATGGGATGATGCCGATGCAGAAGTGATCTGCAGGCAGCTGGGCCTCAGTGGCATTGC
  CAAAGCATGGCATCAGGCATATTTTGGGGAAGGGTCTGGCCCAGTTATGTTGGATGAAGTACGCTGCACT
  GGGAATGAGCTTTCAATTGAGCAGTGTCCAAAGAGCTCCTGGGGAGAGCATAACTGTGGCCATAAAGAAG
  ATGCTGGAGTGTCCTGTACCCCTCTAACAGATGGGGTCATCAGACTTGCAGGTGGGAAAGGCAGCCATGA
  GGGTCGCTTGGAGGTATATTACAGAGGCCAGTGGGGAACTGTCTGTGATGATGGCTGGACTGAGCTGAAT
  ACATACGTGGTTTGTCGACAATTGGGATTTAAATATGGTAAACAAGCATCTGCCAACCATTTTGAAGAAA
  GCACAGGGCCCATATGGTTGGATGACGTCAGCTGCTCAGGAAAGGAAACCAGATTTCTTCAGTGTTCCAG
  GCGACAGTGGGGAAGGCATGACTGCAGCCACCGCGAAGATGTTAGCATTGCCTGCTACCCTGGCGGCGAG
  GGACACAGGCTCTCTCTGGGTTTTCCTGTCAGACTGATGGATGGAGAAAATAAGAAAGAAGGACGAGTGG
  AGGTTTTTATCAATGGCCAGTGGGGAACAATCTGTGATGATGGATGGACTGATAAGGATGCAGCTGTGAT
  CTGTCGTCAGCTTGGCTACAAGGGTCCTGCCAGAGCAAGAACCATGGCTTACTTTGGAGAAGGAAAAGGA
  CCCATCCATGTGGATAATGTGAAGTGCACAGGAAATGAGAGGTCCTTGGCTGACTGTATCAAGCAAGATA
  TTGGAAGACACAACTGCCGCCACAGTGAAGATGCAGGAGTTATTTGTGATTATTTTGGCAAGAAGGCCTC
  AGGTAACAGTAATAAAGAGTCCCTCTCATCTGTTTGTGGCTTGAGATTACTGCACCGTCGGCAGAAGCGG
  ATCATTGGTGGGAAAAATTCTTTAAGGGGTGGTTGGCCTTGGCAGGTTTCCCTCCGGCTGAAGTCATCCC
  ATGGAGATGGCAGGCTCCTCTGCGGGGCTACGCTCCTGAGTAGCTGCTGGGTCCTCACAGCAGCACACTG
  TTTCAAGAGGTATGGCAACAGCACTAGGAGCTATGCTGTTAGGGTTGGAGATTATCATACTCTGGTACCA
  GAGGAGTTTGAGGAAGAAATTGGAGTTCAACAGATTGTGATTCATCGGGAGTATCGACCCGACCGCAGTG
  ATTATGACATAGCCCTGGTTAGATTACAAGGACCAGAAGAGCAATGTGCCAGATTCAGCAGCCATGTTTT
  GCCAGCCTGTTTACCACTCTGGAGAGAGAGGCCACAGAAAACAGCATCCAACTGTTACATAACAGGATGG
  GGTGACACAGGACGAGCCTATTCAAGAACACTACAACAAGCAGCCATTCCCTTACTTCCTAAAAGGTTTT
  GTGAAGAACGTTATAAGGGTCGGTTTACAGGGAGAATGCTTTGTGCTGGAAACCTCCATGAACACAAACG
  CGTGGACAGCTGCCAGGGAGACAGCGGAGGACCACTCATGTGTGAACGGCCCGGAGAGAGCTGGGTGGTG
  TATGGGGTGACCTCCTGGGGGTATGGCTGTGGAGTCAAGGATTCTCCTGGTGTTTATACCAAAGTCTCAG
  CCTTTGTACCTTGGATAAAAAGTGTCACCAAACTGTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003619 unedited
  GGCCGCGAAATTCGCACGAGGCCGCCCCCTCCTCTTCTCCGCTCCAAGCCCGAGAAGCTG
  GGGAGCATGGACCAGACCCCGCAGCGCTGGCACCATGACGCTCGCCCGCTTCGTGCTAGC
  CCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTGTCCTCAATGATTCCCT
  CCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCTTCCCAC
  CCAGCAGCGGCCCCCGACGACGCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCC
  GCGGGCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCCCCGGCCGCA
  CCCCTGGGGCTGCCCCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTG
  TCTGCGGTGGGCGGAGGTGCCACCCTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCA
  GCTGCGAGGACAGCGCCACAACTTTTGTCGGAGCCCCGACGGCGCGGGCAGACCCTTGGT
  GTTTCTACGGAGACGCCCGTGGCAAGGGTGGACTGGGGCTACTGCGACTGCAGACACGGA
  TCAGTACGACTTCGTGGCGGCAAAAATGAGTTTGAAGGCACAGTGGAAGTATATGCAAGT
  GGGAGGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGTCATTT
  GTCACCAGCTGCAGCTGGGGAGGAAAAGGAATAGCAANACAACCCCGTTTTCTGGACTGG
  GCCTTATTCCATTTATTGGAGCCATGTCCCGTGCCGAGGAGATGAGAAAAATACTGCTTT
  GTGAAAAGACTCTGCAGGGGNGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003619
• ORF Size: 2628 bp
• Insert Size: 3410
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003619.2, NP_003610.1
• RefSeq Size: 4573
• RefSeq ORF: 2628
• Locus ID: 8492
• Domains: KR, SR, Tryp_SPc
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]