p38 (MAPK14) (NM_001315) Human Untagged Clone

CAT#: SC126560

MAPK14 (untagged)-Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 1


  "NM_001315" in other vectors (7)

Reconstitution Protocol

USD 610.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MAPK14
Synonyms CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC126560 sequence for NM_001315 edited (data generated by NextGen Sequencing)
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA

Clone variation with respect to NM_001315.2
>OriGene 5' read for NM_001315 unedited
GCAGCAGCTGGAACGGGAGTACTGCGACGCGGCCCGGAGTCGGCCTTGTAGGGGCGAAGG
TGCAGGGAGATCGCGGCGGGCGCAGTCTTGAGCGCCGGAGCGCGTCCCTGCCCTTAGCGG
GGCTTGCCCCAGTCGCAGGGGCACATCCAGCCGCTGCGGCTGACAGCAGCCGCGCGCGCG
GGAGTCTGCGGGGTCGCGGCAGCCGCACCTGCGCGGGCGACCAGCGCAAGGTCCCCGCCC
GGCTGGGCGGGCAGCAAGGGCCGGGGAGAGGGTGCGGGTGCAGGCGGGGGCCCCACAGGG
CCACCTTCTTGCCCGGCGGCTGCCGCTGGAAAATGTCTCAGGAGAGGCCCACGTTCTACC
GGCAGGAGCTGAACAAGACAATCTGGGAGGTGCCCGAGCGTTACCAGAACCTGTCTCCAG
TGGGCTCTGGCGCCTATGGCTCTGTGTGTGCTGCTTTTGACACCAAAACGGGGTTACGTG
TGGCAGTGAAGAAGCTCTCCAGACCATTTCAGTCCATCATTCATGCGAAAAGACCTACAG
AGAACTGCGGTTACTTAAACATATGAAACATGAAAATGTGATTGGTCTGTTGGACGTTTT
TACACCTGGCAGGTCTCTGGAGGAATCAATGATGTGTATCTGGTGACCCATCTCAGGGGG
GCAGATCTGAACACATTGTGAAAAGTCAAAACTTACAGATGACATGTTCAGTTCCTTATC
TACCAAATCTTCGAGGTCTAAATATATACATCCAGCTGACTAATTACAGGGACCTAAACC
TAATAATTAACTNGAATGAAAATGGNACCGAGATCTGGATTTGGACGGCCN
>OriGene 3' read for NM_001315 unedited
CATCTTGNACCGCGCCGCAATTTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTAAAATTGAAAAAAAGGCTTTATTTTAACCAGGGGTATTGT
CTGACATCCTATACGGCATAACTGATTACACCCAAGTTCATGAATACAAATAAAATACCA
ATTCCCCTCATTCTCTTTTTTGTTTTCTGGCCAAAAAAATCAGGAAATGGGACCATTATG
CTCAAAAACCGAAAAACTTTTCCAAAACCTCCAGCTTAAAGTCCAGGCTTCCAAAACATG
CAGCCTCCTAACACGTATGGGGCCACATGTGCAAAAACCTTTATTACAAAATATTCAAAG
CAGTTTTTTTGTAGGAAATCACCCGACCTTTTACAACCAAACATGGGTGATAAAATTCAT
CTTGCTGGGGATGGGGAGGATTTAAACTGCAATAAAGGAAATGAGGCCTTTACTTTAAAG
GTTCACTTTCCTTAAAAGGGGGAAAGTCCCGGGTGAAAGGGAATCGCCATCAGTCTGCCT
CCTTCCTTTTTGCTCCAGTTGACTCAGGGGGTCCACCCTGGCCCTCTGGAAACATGTATC
ACTGCCCTGATTGAAAAATGGAAACACCTTGGCCCAAATAAAGATTCTGTCATACACCCA
ACACTGGAAGGGACTTTATACTTTCTTATTACCAAAAAGCTTAATATATGAGCCCTAATG
TTAAACCAAATGCCTGAATTTTCACAAGTTTAAAAAAGAACCCTTCTCCACCCTGGAGAT
ATTTTATTCTTTATAAAGGTGAAAAATCAAAATATTAAAAAAATTTGCCCCTTTTTCCCC
CATTAAAGGGAAACCCCATTCCAAAAGAATCCCTACATATCCCACAAATTTGAAACAAAA
TTTTATTTTCCCCCCACCAGAATATTATGTGTAC
Restriction Sites NotI-NotI     
ACCN NM_001315
Insert Size 4110 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001315.1, NP_001306.1
RefSeq Size 3757 bp
RefSeq ORF 1083 bp
Locus ID 1432
Cytogenetics 6p21.31
Domains pkinase, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
Gene Summary 'The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) encodes the longest isoform (1).

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