Gephyrin (GPHN) (NM_020806) Human Untagged Clone

CAT#: SC126619

GPHN (untagged)-Human gephyrin (GPHN), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GPHN
• Synonyms: GEPH; GPH; GPHRYN; HKPX1; MOCODC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_020806, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGTGAGTG
  ATAGTTGCTTCAGGAATCTTGCAGAAGACCGCAGTGGGATAAATCTCAAAGATCTCGTACAAGATCCTTC
  TTTGTTGGGTGGGACTATATCAGCATACAAGATAGTACCAGATGAAATAGAAGAAATCAAGGAAACCCTG
  ATAGATTGGTGTGATGAAAAGGAACTTAATTTGATATTAACAACTGGAGGAACAGGATTTGCACCACGAG
  ATGTCACTCCAGAGGCCACAAAAGAAGTAATAGAACGGGAAGCACCAGGGATGGCCCTGGCAATGCTGAT
  GGGATCACTTAATGTTACACCTCTGGGCATGCTCTCTAGGCCTGTATGTGGAATCAGAGGGAAAACGCTC
  ATAATTAACCTGCCAGGTAGCAAGAAAGGATCTCAGGAATGCTTTCAATTCATACTGCCAGCTCTACCTC
  ATGCCATTGACCTTTTACGTGATGCCATTGTAAAAGTAAAGGAGGTGCATGATGAACTTGAAGATTTGCC
  TTCCCCACCTCCCCCTCTTTCCCCTCCTCCTACTACCAGCCCCCATAAACAGACAGAAGACAAAGGAGTT
  CAATGTGAGGAAGAGGAAGAAGAGAAGAAAGACAGTGGTGTTGCTTCAACAGAAGATAGTTCCTCATCAC
  ATATAACTGCAGCAGCCATTGCTGCCAAGAAGCATCCATTCTACACCAGTCCTGCTGTTGTCATGGCACA
  CGGTGAACAGCCCATCCCTGGTCTCATCAATTATTCCCATCATTCAACAGATGAACGGATTCCAGACTCC
  ATCATTTCTCGTGGTGTTCAGGTGCTCCCACGAGACACAGCCTCCCTCAGCACTACTCCTTCAGAATCGC
  CTCGTGCTCAGGCTACATCTCGCCTCTCTACAGCTTCCTGCCCAACACCAAAAGTCCAGTCCAGGTGCAG
  CAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGC
  ATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTGCTTG
  GGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAA
  TTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGT
  TTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGG
  TTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAG
  GGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATC
  AGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAG
  AGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCAT
  GTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGT
  TCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGACAACC
  CAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGT
  ATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGC
  AGGGTTTTTATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAA
  TCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAG
  GAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTT
  GATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGA
  GTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCC
  AAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_020806 unedited
  CGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTTTCTCCCGGCTCCTGTCAGTG
  CGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATC
  AAATCCGTGTCGGAGTCCTTACAGTGAGTGATAGTTGCTTCAGGAATCTTGCAGAAGACC
  GCAGTGGGATAAATCTCAAAGATCTCGTACAAGATCCTTCTTTGTTGGGTGGGACTATAT
  CAGCATACAAGATAGTACCAGATGAAATAGAAGAAATCAAGGAAACCCTGATAGATTGGT
  GTGATGAAAAGGAACTTAATTTGATATTAACAACTGGAGGAACAGGATTTGCACCACGAG
  ATGTCACTCCAGAGGCCACAAAAGAAGTAATAGAACGGGAAGCACCAGCGATGGCCCTGG
  CAATGCTGATGGGATCACTTAATGTTACACCTCTGGGCATGCTCTCTAGGCCTGTATGTG
  GAATCAGAGGGAAAACGCTCATAATTAACCTGCCAGGTACCAAGAAAGGATCTCAGGAAT
  GCTTTCAATTCATACTGCCAGCTCTACCTCATGCCATCGACCTTTCAACGGATGCCCATT
  GAAAAGTAAAAGATGTGCCTGAAGAACTTGAGATTTGCCTTCCCACCTCCCCTTTTTCCC
  TTCTCCTACTACCAGCCCCTTAACCGACAAAGACCAAGCATTCATGTGACGACAAACGAA
  AAAAAAAAAACACCGGTGGTGCTTAACAAAGAACTTTCCTCTCCCTATACTGCACACCCT
  CTGCTGCCAAATACCAACTCCTTATTCTCGGGGGGGGAAGGGCTTCCCAAACACAACTCC
  TCTACACTCTTCTTTAAAACGCCCGGGTCAGCTTACTTTGCCTTTTCAATTTCCTGCCAA
  CACAAAAATTGTGTTTCCACCCCACTCCCCATACTGTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_020806 unedited
  CCGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTAAATAATGATCAAGGAATTTTTTT
  ATTCATTAAGTTTCAGTATCATTACAGAAAATGTTATGGTACAGAATTGTTTAACATTAT
  TTTGTCTTTGCTCTTGATTTCCACATGAATGCTGGTAACACTAATATCTGTACAAGATCA
  GTCTTTGATTTTATTTTTTTGTTCTGTACAATTTTAAATGTATTGGTTAAAAAGGCTGTC
  AGCACTTAAGGAAGCATTTTTTCTTCAGTTTGTTTCTTCAAATAAAAGGTGTCCAGTTAC
  TGCCCAAGAGTACTGTGCCGTGAGGCTATTGGGGCGAGAAACCTCCCTGGATGCTCTGCA
  GGGGATGGTTCTTGAGGCAAGGCAGAGCCTCCACCCAGTCAGTCTTCTTTTGGCACTGTG
  CACATAAACACGAGATACATGAGAAAGAACAAGCAAAAGCTCTCTGTAAAGCAGTTATGA
  AGCATACTAAGAAGGGAAATCCAAGTGTTGCCTACGCTAGTATAAATAAGCAGACAGCCT
  TGATTTAAGAGCATAAGTAGTTGTATTCTAAAGATGAGAAAAACACAAGTTCTGCAGGCA
  CCTACCGCTGTCTACTAAAAGCTATCGCTATCAGACCTATCATTGAACACACAAAGCAAT
  TTGCCAGAAAGGATAAATCTGCCTTGAATAATCAGAACAGATTTTCTGTTAAGATTATTT
  TGAGCGTCTTTTTCTTTAAAAGATATTAAATCCCTTGGAATATAATTCAAGATGTTGACT
  ATCAGATCACCTTTATCCATATGGGAAACTAGCCTGGCCGTGCTTTTACAGGATCCGTCA
  TGGATGGGGACTGCTTAAACTCTTCCCGCGGGGACCCTCTACCGCAAATGCCTGCCTCCC
  ACCCCCCCTTTGGGACTCCCCTCCTGTTTGCCTTGGAGGAACCAAATACCTGGGCCTGGC
  TTCCCTAAGACGGTCCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_020806
• ORF Size: 2310 bp
• Insert Size: 3370
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_020806.4, NP_065857.1
• RefSeq Size: 4318
• RefSeq ORF: 2310
• Locus ID: 10243
• Domains: MoCF_biosynth, MoeA_N, MoeA_C
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1), also known as GephP1, represents the longer transcript and encodes the longer isoform (1).