GM2A (NM_000405) Human Untagged Clone

CAT#: SC126904

GM2A (untagged)-Human GM2 ganglioside activator (GM2A), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GM2A
• Synonyms: GM2-AP; SAP-3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC126904 sequence for NM_000405 edited (data generated by NextGen Sequencing)
  ATGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGGCCCCT
  GCGCAAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT
  GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCATCGTT
  CCTGGAAATGTGACCCTCAGTGTCATGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG
  AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA
  GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT
  ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC
  AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC
  AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT
  CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAA
  
  Clone variation with respect to NM_000405.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000405 unedited
  NGCTTCAGGATTTTGTAATACGACTCACTATAGGGCGGCCGCGNAATTCGCACCAGCCGA
  TGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGGCCCCTG
  CGCANAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT
  GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCATCGTT
  CCTGGAAATGTGACCCTCAGTGTCATGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG
  AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA
  GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT
  ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC
  AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC
  AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT
  CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAACATGGCATCTGCCACAGC
  AGAATGGAGCGGTGTGAGGAAGGTCCCTTTTCCTCTGTTNTGTGTTTGCCAAGGCCAAAC
  TCCCACTCTCTGCCCCCCTTTAATCCCCTTTCTACAGTGAGTCCACTACCCTCACTGAAN
  ATCATTNTGTACCACTTACATTNTANGCTGGNGCAAGCAGCCCTGACCTAAGGGAGAATG
  AGTGGNACAGTTCTTGATAGCCCAGGGCATCTGCTGGGCTGACCACGTTACTCATCCCCG
  TTAACATTCTCTCTAAGAGCCTCGTTCATTTNCAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000405
• ORF Size: 582 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_000405.3, NP_000396.2
• RefSeq Size: 2521
• RefSeq ORF: 582
• Locus ID: 2760
• Domains: ML
• Protein Families: Druggable Genome
• Protein Pathways: Lysosome
• Gene Summary: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
  Transcript Variant: This variant (1) encodes the longer isoform (1).