HRASLS3 (PLA2G16) (NM_007069) Human Untagged Clone

CAT#: SC126921

PLA2G16 (untagged)-Human phospholipase A2, group XVI (PLA2G16), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PLA2G16
• Synonyms: AdPLA; H-REV107; H-REV107-1; HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16; PLAAT-3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC126921 sequence for NM_007069 edited (data generated by NextGen Sequencing)
  ATGCGTGCGCCCATTCCAGAGCCTAAGCCTGGAGACCTGATTGAGATTTTTCGCCCTTTC
  TACAGACACTGGGCCATCTATGTTGGCGATGGATATGTGGTTCATCTGGCCCCTCCAAGT
  GAGGTCGCAGGAGCTGGTGCAGCCAGTGTCATGTCCGCCCTGACTGACAAGGCCATCGTG
  AAGAAGGAATTGCTGTATGATGTGGCCGGGAGTGACAAGTACCAGGTCAACAACAAACAT
  GATGACAAGTACTCGCCGCTGCCCTGCAGCAAAATCATCCAGCGGGCGGAGGAGCTGGTG
  GGGCAGGAGGTGCTCTACAAGCTGACCAGTGAGAACTGCGAGCACTTTGTGAATGAGCTG
  CGCTATGGAGTCGCCCGCAGTGACCAGGTCAGAGATGTCATCATCGCTGCAAGCGTTGCA
  GGAATGGGCTTGGCAGCCATGAGCCTTATTGGAGTCATGTTCTCAAGAAACAAGCGACAA
  AAGCAATAA
  
  Clone variation with respect to NM_007069.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007069 unedited
  CACGACTCTCTATAGGGCGGCCGCGAATTCGGCACGAGGCAGACATCTACGCAGCGAAAT
  CGAGCCTGGCCTTGAGGGTCCACACCGCGAGGGAAGATGCGTGCGCCCATTCCAGAGCCT
  AAGCCTGGAGACCTGATTGAGATTTTTCGCCCTTTCTACAGACACTGGGCCATCTATGTT
  GGCGATGGATATGTGGTTCATCTGGCCCCTCCAAGTGAGGTCGCAGGAGCTGGTGCAGCC
  AGTGTCATGTCCGCCCTGACTGACAAGGCCATCGTGAAGAAGGAATTGCTGTATGATGTG
  GCCGGCAGTGACAAGTACCAGGTCAACAACAAACATGATGACAAGTACTCGCCGCTGCCC
  TGCAGCAAAATCATCCAGCGGGCGGAGGAGCTGGTGGGGCAGGAGGTGCTCTACAAGCTG
  ACCAGTGAGAACTGCGAGCACTTTGTGAATGAGCTGCGCTATGGAGTCGCCCGCAGTGAC
  CAGGTCAGAGATGTCATCATCGCTGCAAGCGTTGCAGGAATGGGCTTGGCAGCCATGATC
  CTTATTGGAGTCATGTTCTCAAGATACAAGCGACAAAAGCAATAACTGAAAAAGACTGTC
  CTGTCAGCGATGACTTTATACATCAAGGAGGTCTTGTTTTGCTAGAGAGTTTAGAGTTTT
  GGTTTGTGGATTTCATTGCGATTTATAATAAGGCTTATTTCACAGAATANACTAAGCANN
  AAAAAAAAAAAAAACTCGACTCTATATTGCGGCCCGCGTCATAGCTGTTTCCTGAACAGA
  TCCCGGGGTGGCATCCCTGTGACCCCTCCCCATTGCTTCTCTGGCCCTGGNAGTTGCACT
  CCAGTGCCACCAGCCTGTCCTATAAAATTAGTTGCATATTTGTCTGACANGGCCCTCATA
  TATATGGGGGGGGGGGGGTGCTTTCCCCCGCTCCATCTACTCACCCATTGCGCCTAATAA
  CCAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007069
• ORF Size: 489 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007069.1, NP_009000.1
• RefSeq Size: 1070
• RefSeq ORF: 489
• Locus ID: 11145
• Domains: NC
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). Shows phospholipase A1 and A2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity (PubMed:19047760). Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity). May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines (PubMed:22605381, PubMed:25383759). The relevance of acyltransferase activity in vivo is however unclear and would require additional evidences (PubMed:22605381, PubMed:25383759). Also has weak lysophospholipase activity. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.