MRE11 (NM_005590) Human Untagged Clone

CAT#: SC126932

MRE11A (untagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2


  "NM_005590" in other vectors (6)

Reconstitution Protocol

USD 1,390.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MRE11
Synonyms ATLD; HNGS1; MRE11A; MRE11B
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC126932 sequence for NM_005590 edited (data generated by NextGen Sequencing)
ATGAGTACTGCAGATGCACTTGATGATGAAAACACATTTAAAATATTAGTTGCAACAGAT
ATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTC
GATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGAT
CTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTACATACCTGCCTCGAGTTATTAAGA
AAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAAC
TTTGGTTTTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATT
CCAGTGTTTAGTATTCATGGCAATCATGACGATCCCACAGGGGCAGATGCACTTTGTGCC
TTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAG
AAGATAGACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGT
TTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGTTTGTCAATAAAAAAGTAACAATG
TTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGG
AGTAAACATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTT
GTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTCCAACCAAAAATGAACAACAGCTG
TTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTA
AAGAAACATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCT
CTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTGTTCTAGCTAATCATCCAGACATT
TTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATT
GAAGAAATGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAG
CCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTTTTGAACCTTTCAGTGTTCTTCGC
TTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGG
CATAGAGAACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAG
CCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTGTAAAACAGTACTTTCAAACCGCA
GAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAA
TTTGTGGACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAA
ACACAGCGATTTCTTAAAGAACGTCATATTGATGCCCTCGAAGACAAAATCGATGAGGAG
GTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGT
GAGGCTATGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTT
AGTGCTGATGACCTTATGAGTATAGATTTAGCAGAACAGATGGCTAATGACTCTGATGAT
AGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGA
GGGCAGAATTCAGCATCGAGAGGAGGGTCTCAANNNNNNNNNNNCTTTAAATCTACAAGA
CAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGATTGAGGTAGATGAA
TCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGC
ACATCATCCAGCAAAATCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCA
AGTGAGGATGATGATGATGATCCTTTTATGAACACTAGTTCTTTAAGAAGAAATAGAAGA
TAA

Clone variation with respect to NM_005590.3
1774 a=>n;1775 g=>n;1776 a=>n;1777 g=>n;1778 g=>n;1779 a=>n;1780 a=>n;1781 g=>n;1782 a=>n;1783 g=>n;1784 c=>n
>OriGene 5' read for NM_005590 unedited
CTGACATTTGAGTACAGTACCCAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTT
GACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACATTTAAAATAT
TAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATA
CGTTTGTAACACTCGATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTT
TGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTACATACCTGCC
TCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTG
ATCAGTCAGTCAACTTTGGTTTTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACC
TCAACATTTCAATTCCAGTGTTTAGTATTCATGGNCATCATGACGATCCCACAGGGATGC
ACTTTGTGCCTTGGACATTNTAAGTTGTGCTGGATTTGTNAATCACTTTGGACGTTCAAT
GTCTGTGGAGAGATAGACATTAGTCCGGTTTTGCTTAAAAAGGAGCACAAGATTGCCTAT
ATGGTTTAGGATCCATTCCGATGAAAGGCTCTATCGATGTTTGTCATAAAAAGTACATGT
TGAGACAAGGAGAGAGACTCTGGGGTACTTATTGTGTTCTCAGACAGAGTACTTGGAGCC
TACCTCTTCAACATTTTGGAGCTCTTGATCTTGAATTGGGCCTGACTGATGAAAAACTCA
CAAAGACACCCTGTTTTTCTCAACTGAAGCAGGGTCTCTCTCCCGG
>OriGene 3' read for NM_005590 unedited
TATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTAAGGAAAAAAAC
TTTATTCCTTTTTTCCTAGGAACTTGTCAGGATACTTTAGTGACCATTCCCTCACTATAA
CTCTCACCCAGACCCACCTAACTGATGCATGAGAAGAGCCACTAGCTGATGTGGCCCACA
GCTCAGACTGAGCCAGCATGGCTTGCGCAGGGGTAGGTAGCACAGCATCATCCAGACACT
GCCTCCCCTGGTAGCTTCCATTACATCATGGACAGCACTGCTCTTCCCTGACTTAACCTT
CTGCTTTGTTCAAATACTAGAAATATTAGATTTCAAGTTCAATAAAGATGTGGGCAGATC
TGCCTAAGAATATTTCACAGGACAACGCCTTCCACTGAGTTAATGCTACTTGCTCAAATA
ACCCTTATGCTCAAGCCAGGTACAGAAAAAATATTTTTAAGAAAGTCAATACAATGTTAT
ATTGCAAGTTCTGACTTACGCCTCTTCAAACGTGCTATATGAGGCAGCCACTAACCAAGT
GTCTGTCTCTTATAATTNGACACATTCCAGGATGACTATTCTTAATGGTCATGAGTATCA
CTGAGTCAAGGCTCTGCCTCCTACCTATAAAGAAATGTCGGGCCCACTGTACCTCCGAAG
ACGTATAACTCCCCACTTATAAGTATCGCTGGTCGCCCACCACCCCCAGAAGGAATAACC
CTCAGGGCCTCTTTTCCCCGAGGGATCATATCGAATGGGGTTATTTAACCTTACCTCTGA
AGCAGGCCCATTCCTCATCTCTCCCCGCAAACACGGTTGGACTGCACCTTTTACATGGGC
CTTTACGAATTCTCGACCTCGCCCTCTCCGAATGTCTCTCGGGCACCCCCAGGGAATCAT
ACCTGCTCACGCGCAACCTTGCTTTGCTTTCGCCTCCCCCTCCCTATCTCTCTCCAGGGG
TCACGCCCCCCCTCTTAATA
Restriction Sites NotI-NotI     
ACCN NM_005590
Insert Size 4000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005590.3, NP_005581.2
RefSeq Size 5164 bp
RefSeq ORF 2043 bp
Locus ID 4361
Cytogenetics 11q21
Domains Metallophos, Mre11_DNA_bind
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Homologous recombination, Non-homologous end-joining
Gene Summary 'This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform 2 lacks an internal segment, compared to isoform 1.

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