BACE2 (NM_138991) Human Untagged Clone

CAT#: SC126981

BACE2 (untagged)-Human beta-site APP-cleaving enzyme 2 (BACE2), transcript variant c

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BACE2
• Synonyms: AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC126981 sequence for NM_138991 edited (data generated by NextGen Sequencing)
  ATGGGCGCACTGGCCCGGGCGCTGCTGCTGCCTCTGCTGGCCCAGTGGCTCCTGCGCGCC
  GCCCCGGAGCTGGCCCCCGCGCCCTTCACGCTGCCCCTCCGGGTGGCCGCGGCCACGAAC
  CGCGTAGTTGCGCCCACCCCGGGACCCGGGACCCCTGCCGAGCGCCACGCCGACGGCTTG
  GCGCTCGCCCTGGAGCCTGCCCTGGCGTCCCCCGCGGGCGCCGCCAACTTCTTGGCCATG
  GTAGACAACCTGCAGGGGGACTCTGGCCGCGGCTACTACCTGGAGATGCTGATCGGGACC
  CCCCCGCAGAAGCTACAGATTCTCGTTGACACTGGAAGCAGTAACTTTGCCGTGGCAGGA
  ACCCCGCACTCCTACATAGACACGTACTTTGACACAGAGAGGTCTAGCACATACCGCTCC
  AAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGACGGGCTTCGTTGGGGAA
  GACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCAACATTGCCACTATT
  TTTGAATCAGAGAATTTCTTTTTGCCTGGGATTAAATGGAATGGAATACTTGGCCTAGCT
  TATGCCACACTTGCCAAGCCATCAAGTTCTCTGGAGACCTTCTTCGACTCCCTGGTGACA
  CAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCGGCTTGCCCGTTGCT
  GGATCTGGGACCAACGGAGGTAGTCTTGTCTTGGGTGGAATTGAACCAAGTTTGTATAAA
  GGAGACATCTGGTATACCCCTATTAAGGAAGAGTGGTACTACCAGATAGAAATTCTGAAA
  TTGGAAATTGGAGGCCAAAGCCTTAATCTGGACTGCAGAGAGTATAACGCAGACAAGGCC
  ATCGTGGACAGTGGCACCACGCTGCTGCGCCTGCCCCAGAAGGTGTTTGATGCGGTGGTG
  GAAGCTGTGGCCCGCGCATCNNNGCTTTACATTCAGCCCATGATGGGGGCCGGCCTGAAT
  TATGAATGTTACCGATTCGGCATTTCCCCATCCACAAATGCGCTGGTGATCGGTGCCACG
  GTGATGGAGGGCTTCTACGTCATCTTCGACAGAGCCCAGAAGAGGGTGGGCTTCGCAGCG
  AGCCCCTGTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACA
  GAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATT
  GTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTG
  CTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCC
  TCTCTGGTCAGACATCGCTGGAAATGA
  
  Clone variation with respect to NM_138991.1
  981 t=>n;982 c=>n;983 t=>n
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_138991 unedited
  TACCCCCGCCCCGTTGGCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGC
  AGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCG
  AATTCGGCACGAGGGCCGAGTCGCTGAGCCGCGGCTGCCGGACGGGACGGGACCGGCTAG
  GCTGGGCGCGCCCCCCGGGCCCCGCCGTGGGCATGGGCGCACTGGCCCGGGCGCTGCTGC
  TGCCTCTGCTGGCCCAGTGGCTCCTGCGCGCCGCCCCGGAGCTGGCCCCCGCGCCCTTCA
  CGCTGCCCCTCCGGGTGGCCGCGGCCACGAACCGCGTAGTTGCGCCCACCCCGGGACCCG
  GGACCCCTGCCGAGCGCCACGCCGACGGCTTGGCGCTCGCCCTGGAGCCTGCCCTGGCGT
  CCCCCGCGGGCGCCGCCAACTTCTTGGCCATGGTAGACAACCTGCAGGGGGACTCTGGCC
  GCGGCTACTACCTGGAGATGCTGATCGGGACCCCCCCGCAGAAGCTACAGATTCTCGTTG
  ACACTGGAAGCAGTAACTTTGCCGTGGCAGGAACCCCGCACTCCTACATAGACACGTACT
  TTGACACAGAGAGGTCTAGCACATACCGCTCCAGGGCTTTGACGTCACAGTGAAGTACAC
  ACAAGGAAGCTGGACGGGNCTTCGTGGGGAAGACCTCGTCACCATCCCCAAAGGGCTTCA
  TACTTCNTTTTCTTGTCAACATGCCACTATTNNTGATCAGAGAATTTCTTTTTGCCTGGG
  ATAAATGGGAATGGAATACTGGCCTAGCTATGCCCACTTGCAGCCATCAAGTCTCTGGAG
  ACTTCTCGACTCCTGGTGAACAGCAAATCCCCACGTTCTCATGCAAAGTGTTGAGCCGCT
  GCCGTGTTTGATCTGACAACGGGGAGATTGTTTTGGGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_138991 unedited
  ANAGTCGAGACCTTTCCTTTTTTTTTTAGTTCTTTCTCATCAAAACAGATTTATTATTTT
  TAAGCAAGGATAAGCATATGTGATAGTGGCCAGCTTGGGGATTGAACTCTTCCTGGTTGA
  TGCACAGTTCAACACCTTTTGGGTCTTGGCTGTTGGGATGATAATTCTTTTGGGTGAAGG
  GAAACAAGCCGTGGTCAAGGCTGCCTGCACCCCCATCCAGGCACAGGACCCTGGGCAAAG
  TCTCAAAAGAGGTAGTGTTTTTACTTTCGCACCAACAATACAACATAAGTATTGGGTACA
  AAAGAAGAAATTTCCTTCCCCTCTACCTCAACGGGCAAAAGGCCTTCCATCTTCAGAAGA
  GGCTTGTGAGGACCATCGGTTGATGACCTCCTAGTGAATTCTGGCTCCCATTCAGAGCAC
  AGAGAAACCCACAAAAGGGGCCTGTGGCTCTGGTTCCAGGTCTCAAGGGTACAGCTTGGT
  TACATCCCCAGGCCCCAGGCTGATTCTCCTGCCATCATACTGCAAGCCTTCCTGTACCAC
  TTTGNACCCAGTTGAGGTCTGGCGGAAAATAACCTCAAAGGCAATTAATACAAAAAGCTT
  CCTGTAAGCTAAGAAGGGTTATCAACTATATGTACTTATTTTTCCAGAGATTGAAGAGAG
  AAGAAACGAGCCAGGCTTTGGTTTTGGTTTATGGTTNNGTGCACATGTAAGAACTTTTGG
  CANTACANACCCCATAGAGCCTGCAGCCCATCCACTCTGTTTTTGTTTANAATGAAATTT
  TTTTTTTTAATATTTTCCTTGAATTGGGGGAGGATTTTAAAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_138991
• ORF Size: 1407 bp
• Insert Size: 2600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_138991.1, NP_620476.1
• RefSeq Size: 2843
• RefSeq ORF: 1407
• Locus ID: 25825
• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease
• Gene Summary: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (c) lacks an alternate in-frame exon, compared to variant a. The encoded isoform (C) is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.