OAZ1 (NM_004152) Human Untagged Clone

CAT#: SC127084

OAZ1 (untagged)-Human ornithine decarboxylase antizyme 1 (OAZ1)


  "NM_004152" in other vectors (4)

Reconstitution Protocol

USD 2,320.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol OAZ1
Synonyms AZ1; AZI; OAZ
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_004152, the custom clone sequence may differ by one or more nucleotides


TTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCGGACCCCA
GCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGG
GGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCATGCCGCTCCTAAGCCTGCACAGCCGCGGCGGC
AGCAGCAGTGAGAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCT
CCTGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTT
CAGCTAACTTATTCTACTCCGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAG
GATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGC
AGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGG
AGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGC
CGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAG
AGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCC
GCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCG
CTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTA
TTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAATTTATATT
TTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGG
AGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAAGATGAGGTATTAATCCCCTCCATTGCTCTCCA
AAAGCCAATAAAGTGATTACACCCGA


>OriGene 5' read for NM_004152 unedited
TCCCCCCCCCCTACCCACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGGGCGGCGGC
GCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCGGACCCCAGCGGCCGGATGGTGAAATC
CTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACC
CAGCGCCACCATCCACGCCAGCCGCACCATGCCGCTCCTAAGCCTGCACAGCCGCGGCGG
CAGCAGCAGTGAGAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCC
TCGGTGGTGCTCCTGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGCCGAGGCCACA
CCCACAGGCCACCCACCCCCCCCCCCCCCCTCACCCCACTCCCATGATCCCCCCGTTGCC
CCTCCCCCCCCCCTGCCACCCCCCTTCCCCCCGCCCCCCCCCACTCCCTCCCCCCCTCCT
TCTCCTCCCCCCATCCACTCATCTTCCCCCCCCTCACACCCCCCCTTTTCTCACCTCCTT
ACCATCTCCACCCCCCCCCACCCCCCCCCCCCTCCCCCCACCCCCACCCCTCTTCCCACC
CCCCACTCACCTCCCCCCTCCTCTCCCCTTCTTTCCATCATCGCCTCCCCCTACCCCCCC
TCCCCCCCCATTCCCCCACCCCGCTTTTCATTCTCCCCCACTCCCCCCCCTCTCCCTCGT
CCCCCCACTATCCACCCCTCCCATCCCTCACCACCCTCTCCTCTCCCCCCCCCCCCCCCC
CCTCCCCCCCCACCCGCCCCCCACGATCTCAATCCCCTATCCCGCTCCCCCCCCATCCGC
CTCTCCCATCCCCCCCAACCCCTCCCCCCCCCTCCCATCCCCTTCGCCCCCCCTCCCCCT
CCTTCAATT
Restriction Sites NotI-NotI     
ACCN NM_004152
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004152.1, NP_004143.1
RefSeq Size 986 bp
RefSeq ORF 408 bp
Locus ID 4946
Cytogenetics 19p13.3
Gene Summary 'The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]'
Transcript Variant: This variant (1) encodes the longer isoform (1). CCDS Note: The expression of the protein represented in this CCDS ID is auto-regulated by polyamine-enhanced translational frameshifting. During translation, a +1 frameshift occurs following codon 68, just preceding a termination codon, thereby enabling translation of the remaining portion of the protein (aa 69-228) in a different reading frame, as experimentally shown for the conserved rat ortholog (PMID:7813017).

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