UNC13B (NM_006377) Human Untagged Clone

CAT#: SC127356

UNC13B (untagged)-Human unc-13 homolog B (C. elegans) (UNC13B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UNC13B
• Synonyms: MUNC13; UNC13; Unc13h2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127356 sequence for NM_006377 edited (data generated by NextGen Sequencing)
  ATGTCACTGCTCTGCGTGCGCGTTAAAAGGGCCAAATTCCAGGGTTCACCAGATAAATTT
  AACACATATGTGACCCTGAAAGTACAGAATGTGAAGAGCACAACTGTAGCAGTTCGTGGT
  GATCAGCCTTCCTGGGAACAGGATTTCATGTTTGAGATTAGTCGCCTGGACCTGGGTCTA
  AGTGTGGAGGTATGGAACAAAGGACTGATCTGGGACACCATGGTGGGGACTGTGTGGATT
  GCGCTGAAGACTATTCGTCAGTCGGATGAGGAAGGGCCTGGGGAATGGTCCACATTAGAG
  GCAGAGACGTTAATGAAAGACGATGAGATCTGTGGAACTAGAAACCCAACTCCTCATAAA
  ATTTTGCTTGATACAAGATTTGAGTTGCCTTTTGATATCCCAGAGGAGGAAGCCAGATAT
  TGGACCTACAAATGGGAGCAAATCAATGCCTTGGGAGCTGACAATGAGTATTCTAGTCAA
  GAAGAAAGCCAGAGGAAGCCATTGCCCACTGCTGCCGCCCAGTGTTCTTTTGAAGACCCT
  GATAGTGCCGTCGATGACCGAGATAGTGACTATCGCAGTGAGACCAGCAACAGCTTCCCA
  CCTCCTTACCATACAGCTTCCCAGCCCAACGCTTCTGTGCACCAGTTCCCTGTGCCGGTG
  CGATCGCCACAGCAGCTGCTACTTCAAGGCAGTTCCCGGGACTCTTGTAATGACTCTATG
  CAAAGTTATGACCTTGATTATCCAGAGCGGCGGGCTATCAGCCCCACCAGCAGCAGTAGG
  TATGGCTCCTCCTGTAATGTGAGTCAAGGAAGCTCTCAGCTAAGTGAACTAGACCAGTAT
  CACGAACAAGATGACGACCATCGGGAGACGGACTCGATTCATTCTTGCCACAGCTCTCAC
  AGCCTGTCCAGAGATGGCCAAGCAGGTTTTGGAGAACAAGAGAAACCCTTGGAGGTGACA
  GGTCAAGCAGAGAAGGAGGCAGCATGTGAACCCAAGGAGATGAAAGAAGATGCCACAACC
  CACCCTCCCCCAGATCTGGTGCTGCAAAAAGACCACTTCCTAGGTCCCCAGGAGAGTTTT
  CCTGAGGAGAATGCATCTTCACCATTTACCCAAGCCAGAGCACATTGGATCCGAGCAGTT
  ACCAAGGTTCGACTCCAGCTGCAGGAGATTCCAGATGATGGTGACCCCTCTCTGCCTCAG
  TGGCTCCCGGAAGGGCCAGCCGGAGGGCTCTATGGCATTGACAGCATGCCAGATTTACGC
  AGAAAGAAGCCACTGCCACTTGTCAGTGATCTGTCACTGGTCCAGTCTCGGAAGGCAGGA
  ATCACTTCTGCAATGGCTACACGCACTTCTCTTAAGGACGAAGAGCTGAAATCCCACGTG
  TATAAGAAAACCCTGCAGGCCTTAATCTACCCCATTTCGTGCACCACTCCTCATAACTTT
  GAGGTCTGGACGGCCACTACCCCAACCTACTGCTATGAGTGTGAAGGCCTGCTCTGGGGC
  ATTGCCCGGCAGGGCATGCGCTGCAGCGAATGTGGAGTCAAGTGCCATGAGAAGTGCCAG
  GATCTGCTCAATGCTGACTGCCTGCAGCGGGCTGCAGAAAAGAGCTGTAAACATGGAGCT
  GAGGACCGGACCCAGAACATTATCATGGCCATGAAGGACCGCATGAAGATCCGAGAGCGA
  AATAAGCCAGAGATCTTTGAAGTTATCCGGGACGTCTTCACAGTGAACAAAGCTGCCCAT
  GTGCAGCAGATGAAAACAGTGAAGCAGAGTGTACTGGATGGCACCTCCAAATGGTCAGCC
  AAGATCACCATTACTGTGGTGTGTGCCCAGGGCCTACAAGCCAAGGACAAAACAGGATCC
  AGTGACCCTTACGTGACTGTGCAAGTCAGCAAAACTAAGAAGCGTACCAAGACCATTTTT
  GGAAACTTGAATCCTGTTTGGGAGGAGAAGTTCCATTTTGAGTGCCACAACTCCTCTGAC
  CGCATTAAGGTGCGTGTATGGGATGAGGATGATGACATCAAGTCAAGAGTAAAGCAACGC
  CTAAAGCGAGAGTCTGATGATTTCCTTGGCCAAACCATCATTGAGGTTCGGACCCTAAGT
  GGCGAGATGGACGTCTGGTACAACTTGGAGAAGAGGACAGACAAATCAGCCGTCTCAGGG
  GCTATCCGACTACAAATCAGTGTGGAGATCAAGGGGGAGGAGAAAGTAGCCCCATACCAC
  GTGCAGTATACATGTCTCCATGAGAATCTTTTCCATTACCTCACAGACATTCAGGGCAGT
  GGAGGAGTCCGCATCCCTGAAGCTCGAGGAGACGATGCCTGGAAGGTGTACTTTGATGAG
  ACAGCCCAAGAAATTGTGGATGAATTTGCCATGCGTTATGGCATTGAGTCCATATATCAG
  GCCATGACGCACTTTGCATGTTTATCATCCAAGTACATGTGTCCTGGTGTGCCAGCAGTG
  ATGAGCACCTTACTGGCCAACATCAACGCCTACTATGCCCACACAACTGCCTCTACCAAT
  GTCTCTGCATCTGATCGCTTTGCAGCCTCCAACTTTGGGAAAGAGAGATTTGTAAAACTG
  CTGGACCAGCTACACAACTCACTGAGGATCGACCTCTCTACATACAGGAATAATTTCCCT
  GCTGGGAGTCCTGAACGGCTTCAGGACTTAAAATCCACAGTGGATTTGCTGACCAGCATT
  ACTTTCTTCAGAATGAAGGTACAAGAACTGCAAAGCCCTCCAAGAGCCAGCCAGGTGGTA
  AAGGATTGTGTGAAGGCCTGTTTGAACTCCACATATGAATATATCTTCAACAACTGCCAC
  GACTTATACAGCCGCCAGTACCAGCTGAAGCAGGAGCTACCTCCAGAGGAACAAGGGCCC
  AGCATTCGGAACCTGGATTTCTGGCCCAAGCTCATCACACTCATCGTGTCAATCATAGAG
  GAAGATAAGAATTCCTACACACCTGTTCTGAACCAGTTTCCTCAGGAGTTGAATGTGGGA
  AAAGTCAGCGCAGAAGTGATGTGGCATTTGTTTGCCCAAGACATGAAATATGCATTGGAG
  GAGCATGAGAAAGACCACCTGTGTAAAAGTGCTGACTACATGAACCTGCACTTCAAGGTG
  AAGTGGCTCCACAATGAATACGTGCGGGATCTGCCTGTCCTCCAGGGGCAGGTGCCTGAG
  TACCCAGCGTGGTTTGAGCAGTTCGTGCTACAATGGCTGGATGAGAATGAGGATGTATCC
  CTGGAATTCCTGCGTGGGGCCCTGGAACGAGATAAGAAGGATGGATTCCAGCAGACATCA
  GAGCATGCACTCTTTTCCTGCTCTGTGGTGGATGTCTTCACACAACTCAATCAGAGCTTT
  GAGATCATCCGGAAGCTGGAATGCCCAGACCCCAGCATCCTTGCCCACTACATGAGGAGG
  TTTGCTAAGACCATCGGGAAGGTGCTGATGCAGTATGCAGACATCTTGTCAAAGGACTTC
  CCAGCCTATTGCACAAAGGAGAAACTGCCCTGCATCCTGATGAACAACGTGCAGCAACTG
  AGGGTCCAGCTGGAGAAAATGTTTGAGGCCATGGGAGGCAAGGAGCTGGACCTTGAAGCT
  GCAGACAGTCTGAAGGAGCTGCAGGTGAAACTGAATACGGTTCTGGATGAGCTCAGCATG
  GTGTTTGGAAACAGTTTCCAGGTACGGATTGATGAGTGTGTTCGACAAATGGCCGACATC
  CTGGGCCAGGTTCGGGGCACAGGGAATGCATCTCCAGACGCCAGGGCCTCAGCGGCTCAG
  GATGCAGATAGCGTACTCCGGCCTCTCATGGACTTCCTGGATGGCAACCTCACCCTCTTT
  GCCACTGTGTGTGAGAAGACGGTTCTGAAGCGTGTACTGAAGGAGCTCTGGCGCGTGGTG
  ATGAACACAATGGAGAGGATGATTGTTCTGCCCCCACTCACTGACCAGACGGGCACCCAG
  CTGATCTTCACTGCTGCCAAGGAGCTGAGCCATCTTTCCAAACTCAAGGATCACATGGTA
  CGAGAGGAAACACGGAATCTCACTCCAAAGCAGTGTGCAGTCCTTGACCTCGCCCTGGAC
  ACCATCAAGCAATACTTCCATGCAGGAGGCAATGGGCTGAAGAAAACCTTCCTGGAGAAG
  AGCCCAGATCTGCAGTCTCTACGCTATGCCCTGTCTCTGTACACACAGACTACTGACACT
  CTCATCAAGACCTTTGTGCGCTCGCAGACCACCCAAGGGTCTGGTGTGGACGATCCTGTG
  GGAGAAGTCTCTATTCAGGTGGACTTGTTTACACACCCTGGTACTGGGGAGCACAAGGTC
  ACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACAGCGGGTATGTTCCGGCCT
  TTCGTGGAGGTGACTATGGTTGGCCCACACCAAAGTGATAAGAAGAGGAAGTTCACAACC
  AAATCCAAAAGCAACAACTGGGCCCCCAAGTACAATGAGACATTCCACTTCCTCCTGGGA
  AATGAGGAGGGGCCCGAGTCCTATGAGTTGCAGATATGCGTGAAGGATTACTGCTTTGCC
  CGGGAAGATCGCGTGCTAGGGCTGGCTGTGATGCCTCTGAGGGATGTCACAGCCAAGGGC
  AGCTGTGCCTGCTGGTGCCCCTTGGGCCGGAAGATCCATATGGATGAGACAGGCCTGACC
  ATTCTCCGGATTTTATCTCAGAGGAGCAATGACGAGGTGGCCCGAGAATTTGTGAAACTC
  AAATCAGAGTCTCGTTCCACGGAGGAGGGGAGCTGA
  
  Clone variation with respect to NM_006377.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006377 unedited
  CGGCCGCGAATTCGGCACGAGCTTGCCCGATCCTCGGCCATGTCACTGCTCTGCGTGCGC
  GTTAAAAGGGCCAAATTCCAGGGTTCACCAGATAAATTTAACACATATGTGACCCTGAAA
  GTACAGAATGTGAAGAGCACAACTGTAGCAGTTCGTGGTGATCAGCCTTCCTGGGAACAG
  GATTTCATGTTTGAGATTAGTCGCCTGGACCGGGGTCTAAGTGTGGAGGTATGGAACAAA
  GGACTGATCTGGGACACCATGGTGGGGACTGTGTGGATTGCGCTGAAGACTATTCGTCAG
  TCGGATGAGGAAGGGCCTGGGGAATGGTCCACATTAGAGGCAGAGACGTTAATGAAAGAC
  GATGAGATCTGTGGAACTAGAAACCCAACTCCTCATAAAATTTTGCTTGATACAAGATTT
  GAGTTGCCTTTTGATATCCCAGAGGAGGAAGCCAGATATTGGACCTACAAATGGGAGCAA
  ATCAATGCCTTGGGAGCTGACAATGAGTATTCTAGTCAAGAAGAAAGCCAGAGGAAGCCA
  TTGCCCACTGCTGCCGCCCAGTGTTGTCACTGGACCTATTTGGGCTGGGGAGAACAACAG
  ACTTTTGAAGACCCTGATAGTGCCGTCGATGACCGAGATAGTGACTATCGCAGTGAGACC
  CAGCACAGCTTCCCACCTCCCTACCATACAGCTTCCCAGCCCAACGCTTNTGTGCACN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006377 unedited
  TAGCTATGNAACGCGGCACGCAATCTAGTGATCGGTTTTTTTTTTTTTTTTTTTGGGTTC
  TTGTTTCATGTAATGGCCAGTACATCTGTGGGCAATGTCGAGTCCTCAGGAAGTCCAGGA
  GGCTGCTACAGAGGAAATCCAAGAACCATGTCACATCTCTCAACAAGTCTTGGGAAGTCC
  ATCTGACTCTCTGAAACAGTTTGTCTCTGACCTCCCAGGAAGTGTGGAGGGCCCCTTCCA
  TCCAGCCTGTACAGAGGGATCAGAGTCCAGGCTCCTTCTATAGGGTTGAATATCAGAGGG
  GAATAGCAAATGACCCCGATGAGAGAGAGAGAGACCAAAGGCTAGATTCTTTCTGCAAGG
  TGGAGGACGGCTAGAAGGCAGTGGCCACAGATGAGCAGGACTTTTTCTAGACTGGTTTCT
  ACAATTTTTGGCTTTGTTCAGGGCCCACCCAAGAAGAAAATACTCCTGGATCCTTCAACT
  AGCCCTCAGGTAGACACATGTTAGAACAGCCTGTCACGTCCTGAAGCATCACTCCCCTGC
  CTATAGGAGTGAGGCAGGGAGACTCCCATGCAGGTGGCCCCTAGTGCCTGGGGTCCAAAG
  AAATATTCTTCTCAAGGCTTTGAAGCACCACGTGAACCACATTCTACTCATGATACAATC
  TGGGGAAAGGGATTAGTACAGCCCATTTCCTAAAGGTATCCTGTTCAGTTTCAAAGCCCC
  TGCTCTCACTGGAGCCACAGAAAATCAGTGGATTCTACCCAAAGGACAGGCTAAATTCTT
  TTCTGTGGACTCCTGCCCTGGCCCTACTCCCATTCAGACCACCGGCTTAACACCAGGGCT
  AGCTGGCTTACCCAGCCGCCAGGCCCCAAGCCCCCACCTCTCAAACTTGGTCCTTCAATG
  GTGAGGTTGTATGCGTCCACATGAAAACGCGTTGCCAGCATATGGTCAAAGGGGGTACTA
  TTATTTCTCACCCTCCCTCTACA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006377
• ORF Size: 4776 bp
• Insert Size: 6360
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006377.2, NP_006368.2
• RefSeq Size: 6328
• RefSeq ORF: 4776
• Locus ID: 10497
• Domains: C2, DAG_PE-bind
• Protein Families: Druggable Genome
• Gene Summary: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]