CERK (NM_022766) Human Untagged Clone

CAT#: SC127404

CERK (untagged)-Human ceramide kinase (CERK)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CERK
• Synonyms: dA59H18.2; dA59H18.3; hCERK; LK4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022766, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGGGCGACGGGGGCGGCGGAGCCGCTGCAATCCGTGCTGTGGGTGAAGCAGCAGCGCTGCGCCGTGA
  GCCTGGAGCCCGCGCGGGCTCTGCTGCGCTGGTGGCGGAGCCCGGGGCCCGGAGCCGGCGCCCCCGGCGC
  GGATGCCTGCTCTGTGCCTGTATCTGAGATCATCGCCGTTGAGGAAACAGACGTTCACGGGAAACATCAA
  GGCAGTGGAAAATGGCAGAAAATGGAAAAGCCTTACGCTTTTACAGTTCACTGTGTAAAGAGAGCACGAC
  GGCACCGCTGGAAGTGGGCGCAGGTGACTTTCTGGTGTCCAGAGGAGCAGCTGTGTCACTTGTGGCTGCA
  GACCCTGCGGGAGATGCTGGAGAAGCTGACGTCCAGACCAAAGCATTTACTGGTATTTATCAACCCGTTT
  GGAGGAAAAGGACAAGGCAAGCGGATATATGAAAGAAAAGTGGCACCACTGTTCACCTTAGCCTCCATCA
  CCACTGACATCATCGTTACTGAACATGCTAATCAGGCCAAGGAGACTCTGTATGAGATTAACATAGACAA
  ATACGACGGCATCGTCTGTGTCGGCGGAGATGGTATGTTCAGCGAGGTGCTGCACGGTCTGATTGGGAGG
  ACGCAGAGGAGCGCCGGGGTCGACCAGAACCACCCCCGGGCTGTGCTGGTCCCCAGTAGCCTCCGGATTG
  GAATCATTCCCGCAGGGTCAACGGACTGCGTGTGTTACTCCACCGTGGGCACCAGCGACGCAGAAACCTC
  GGCGCTGCATATCGTTGTTGGGGACTCGCTGGCCATGGATGTGTCCTCAGTCCACCACAACAGCACACTC
  CTTCGCTACTCCGTGTCCCTGCTGGGCTACGGCTTCTACGGGGACATCATCAAGGACAGTGAGAAGAAAC
  GGTGGTTGGGTCTTGCCAGATACGACTTTTCAGGTTTAAAGACCTTCCTCTCCCACCACTGCTATGAAGG
  GACAGTGTCCTTCCTCCCTGCACAACACACGGTGGGATCTCCAAGGGATAGGAAGCCCTGCCGGGCAGGA
  TGCTTTGTTTGCAGGCAAAGCAAGCAGCAGCTGGAGGAGGAGCAGAAGAAAGCACTGTATGGTTTGGAAG
  CTGCGGAGGACGTGGAGGAGTGGCAAGTCGTCTGTGGGAAGTTTCTGGCCATCAATGCCACAAACATGTC
  CTGTGCTTGTCGCCGGAGCCCCAGGGGCCTCTCCCCGGCTGCCCACTTGGGAGACGGGTCTTCTGACCTC
  ATCCTCATCCGGAAATGCTCCAGGTTCAATTTTCTGAGATTTCTCATCAGGCACACCAACCAGCAGGACC
  AGTTTGACTTCACTTTTGTTGAAGTTTATCGCGTCAAGAAATTCCAGTTTACGTCGAAGCACATGGAGGA
  TGAGGACAGCGACCTCAAGGAGGGGGGGAAGAAGCGCTTTGGGCACATTTGCAGCAGCCACCCCTCCTGC
  TGCTGCACCGTCTCCAACAGCTCCTGGAACTGCGACGGGGAGGTCCTGCACAGCCCTGCCATCGAGGTCA
  GAGTCCACTGCCAGCTGGTTCGACTCTTTGCACGAGGAATTGAAGAGAATCCGAAGCCAGACTCACACAG
  CTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_022766
• ORF Size: 1614 bp
• Insert Size: 4500
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_022766.4, NP_073603.2
• RefSeq Size: 4445
• RefSeq ORF: 1614
• Locus ID: 64781
• Domains: DAGKc
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism
• Gene Summary: CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]). [supplied by OMIM, Mar 2008]