LILRB1 (NM_006669) Human Untagged Clone

CAT#: SC127469

LILRB1 (untagged)-Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LILRB1
• Synonyms: CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127469 sequence for NM_006669 edited (data generated by NextGen Sequencing)
  ATGACCCCCATCCTCACGGTCCTGATCTGTCTCGGGCTGAGTCTGGGCCCCAGGACCCAC
  GTGCAGGCAGGGCACCTCCCCAAGCCCACCCTCTGGGCTGAACCAGGCTCTGTGATCACC
  CAGGGGAGTCCTGTGACCCTCAGGTGTCAGGGGGGCCAGGAGACCCAGGAGTACCGTCTA
  TATAGAGAAAAGAAAACAGCACTCTGGATTACACGGATCCCACAGGAGCTTGTGAAGAAG
  GGCCAGTTCCCCATCCCATCCATCACCTGGGAACATGCAGGGCGGTATCGCTGTTACTAT
  GGTAGCGACACTGCAGGCCGCTCAGAGAGCAGTGACCCCCTGGAGCTGGTGGTGACAGGA
  GCCTACATCAAACCCACCCTCTCAGCCCAGCCCAGCCCCGTGGTGAACTCAGGAGGGAAT
  GTAATCCTCCAGTGTGACTCACAGGTGGCATTTGATGGCTTCAGTCTGTGTAAGGAAGGA
  GAAGATGAACACCCACAATGCCTGAACTCCCAGCCCCATGCCCGTGGGTCGTCCCGCGCC
  ATCTTCTCCGTGGGCCCCGTGAGCCCGAGTCGCAGGTGGTGGTACAGGTGCTATGCTTAT
  GACTCGAACTCTCCCTATGAGTGGTCTCTACCCAGTGATCTCCTGGAGCTCCTGGTCCTA
  GGTGTTTCTAAGAAGCCATCACTCTCAGTGCAGCCAGGTCCTATCGTGGCCCCTGAGGAG
  ACCCTGACTCTGCAGTGTGGCTCTGATGCTGGCTACAACAGATTTGTTCTGTATAAGGAC
  GGGGAACGTGACTTCCTTCAGCTCGCTGGCGCACAGCCCCAGGCTGGGCTCTCCCAGGCC
  AACTTCACCCTGGGCCCTGTGAGCCGCTCCTACGGGGGCCAGTACAGATGCTACGGTGCA
  CACAACCTCTCCTCCGAGTGGTCGGCCCCCAGTGACCCCCTGGACATCCTGATCGCAGGA
  CAGTTCTATGACAGAGTCTCCCTCTCGGTGCAGCCGGGCCCCACGGTGGCCTCAGGAGAG
  AACGTGACCCTGCTGTGTCAGTCACAGGGATGGATGCAAACTTTCCTTCTGACCAAGGAG
  GGGGCAGCTGATGACCCATGGCGTCTAAGATCAACGTACCAATCTCAAAAATACCAGGCT
  GAATTCCCCATGGGTCCTGTGACCTCAGCCCATGCGGGGACCTACAGGTGCTACGGCTCA
  CAGAGCTCCAAACCCTACCTGCTGACTCACCCCAGTGACCCCCTGGAGCTCGTGGTCTCA
  GGACCGTCTGGGGGCCCCAGCTCCCCGACAACAGGCCCCACCTCCACATCTGGCCCTGAG
  GACCAGCCCCTCACCCCCACCGGGTCGGATCCCCAGAGTGGTCTGGGAAGGCACCTGGGG
  GTTGTGATCGGCATCTTGGTGGCCGTCATCCTACTGCTCCTCCTCCTCCTCCTCCTCTTC
  CTCATCCTCCGACATCGACGTCAGGGCAAACACTGGACATCGACCCAGAGAAAGGCTGAT
  TTCCAACATCCTGCAGGGGCTGTGGGGCCAGAGCCCACAGACAGAGGCCTGCAGTGGAGG
  TCCAGCCCAGCTGCCGATGCCCAGGAAGAAAACCTCTATGCTGCCGTGAAGCACACACAG
  CCTGAGGATGGGGTGGAGATGGACACTCGGAGCCCACACGATGAAGACCCCCAGGCAGTG
  ACGTATGCCGAGGTGAAACACTCCAGACCTAGGAGAGAAATGGCCTCTCCTCCTTCCCCA
  CTGTCTGGGGAATTCCTGGACACAAAGGACAGACAGGCGGAAGAGGACAGGCAGATGGAC
  ACTGAGGCTGCTGCATCTGAAGCCCCCCAGGATGTGACCTACGCCCAGCTGCACAGCTTG
  ACCCTCAGACGGGAGGCAACTGAGCCTCCTCCATCCCAGGAAGGGCCCTCTCCAGCTGTG
  CCCAGCATCTACGCCACTCTGGCCATCCACTAG
  
  Clone variation with respect to NM_006669.3
  933 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006669 unedited
  AATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCACACGCAGCTCAGCCTGG
  GCGGCACAGCCAGATGCGAGATGCGTCTCTGCTGATCTGAGTCTGCCTGCAGCATGGACC
  TGGGTCTTCCCTGAAGCATCTCCAGGGCTGGAGGGACGACTGCCATGCACCGAGGGCTCA
  TCCATCCACAGAGCAGGGCAGTGGGAGGAGACGCCATGACCCCCATCCTCACGGTCCTGA
  TCTGTCTCGGGCTGAGTCTGGGCCCCAGGACCCACGTGCAGGCAGGGCACCTCCCCAAGC
  CCACCCTCTGGGCTGAACCAGGCTCTGTGATCACCCAGGGGAGTCCTGTGACCCTCAGGT
  GTCAGGGGGGCCAGGAGACCCAGGAGTACCGTCTATATAGAGAAAAGAAAACAGCACTCT
  GGATTACACGGATCCCACAGGAGCTTGTGAAGAAGGGCCAGTTCCCCATCCCATCCATCA
  CCTGNGAACATGCAGGGCGGTATCGCTGTTACTATGGTAGCGACACTGCAGGCCGCTCAG
  AGAGCAGTGACCCCCTGGAGCTGGTGGTGACAGGAGCCTACATCAAACCCACCCTCTCAG
  CCCAGCCCAGCCCCGTGGTGAACTCAGGAGGGAAATGTATCCTCCAGTGTGACTCACAGG
  TGGGCATTGATGGCTTCAGTCTGTGTAAGGAAGGAGAAGATGAACCCCANCATGCCTGAA
  CTCCCAGCCCATGCCCGTGGTCGTCCCGCGCCATCTTCTCCGTGGGCCCCGTGAGCCGAG
  TCGCAGTGGTGGTACAGTGCTATGCTTATGACTCGAACTCTCCCTATGAGTGGGCTCTAC
  CCATGATCTCCTGGAGCTCTGGTCCTAGGTTTTCTAAAGAGCCATACTCTCAGTGCAGCC
  AGTTCTATCGGGCCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006669 unedited
  TATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCTTTCTTTTTT
  TTTTTTTTTTTTAATTTGAGATGGAGTCTCCCTCTGTCGCCAGGCTGGAGAGCAGTGGTG
  CGATCTTGGCTCACTGAAACCTCTGACTCCCTGGTTCAAGCGATTCTCCTGCCTCAGCCT
  CCCAAATAGCTGGGATTACAGGCACTGCCACCACATCCAGCTAATTTTTGTATTTTTAGG
  AGAGACAGGGTTTCACCATGTTGGCCAAGATGGTCTCGATCTCCTGAACTCGTGATCTGC
  CCGCCTCGGCCTCCCAAAGTGCTGGAATTACAGGCGTGAGCCACCGTGCCCTGCCCTAAA
  TTTCTTATAGGAAAGCCAAGATCATTCATTTCCTACTTTTTTTCTTTCCTAATTCATTCA
  TTCGNGGCTTGTAGTTTTCCAGTTTCATCGCTTGATGTGTAATATTTACATTGCGATTCA
  GTTTAATGCACTTTCTGACTTAGTTTTCTCAGCTACTTCATTGATTATTGAGAAGTCTGT
  TGCTTTATTTCAAAATTGTAGAGACATTAGTTATTTATACTGCAGAATTGAGTGACCCCT
  AAAAGTTCCCAGAGTCTCCTGGGGTAGACCCAGGCTGGGTGGGGTCCAATGGTGCCCACT
  GGGGGGGCAGCTCCCATGCATTCCAGACTCCATGGAGTGTGGGGCCTGCGTCCCCCCCTG
  GGCTAGTGGATGGCCAGAGTGGCGTAAATGCTGGGCACACGCTGGACAGGCCCCTTTCTG
  GGATGGAGGAGGCTCAGTTTGCCTCCCGTCTGACGGTCAAGCTGTGCAGCCGGGCCGAAG
  GCCCATTCCTGGGGGCCTTCAGATGCAGAAGCCTCAGGGGCCATCTGCCTGCCCTTCTCC
  GCTGCCTGCCTGGTGCCCAGGACTCCCCCAACAGGGCGAAAGAGGAAAGCCATTCCCCCC
  AGCCTGGGGGCCCACCCCGCACN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006669
• ORF Size: 1953 bp
• Insert Size: 2880
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006669.2, NP_006660.1
• RefSeq Size: 2984
• RefSeq ORF: 1953
• Locus ID: 10859
• Domains: ig, IGc2, IG
• Protein Families: Transmembrane
• Gene Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Sequence Note: A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species and on the presence of a predicted signal peptide in the protein N-terminus. An upstream in-frame start codon is also present but is only conserved in primates, and use of the upstream start codon would result in a protein that is 17 aa longer at the N-terminus and lacks a predicted signal peptide. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon.