DERL1 (NM_024295) Human Untagged Clone

CAT#: SC127475

DERL1 (untagged)-Human Der1-like domain family, member 1 (DERL1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DERL1
• Synonyms: DER-1; DER1; derlin-1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127475 sequence for NM_024295 edited (data generated by NextGen Sequencing)
  ATGTCGGACATCGGAGACTGGTTCAGGAGCATCCCGGCGATCACGCGCTATTGGTTCGCC
  GCCACCGTCGCCGTGCCCTTGGTCGGCAAACTCGGCCTCATCAGCCCGGCCTACCTCTTC
  CTCTGGCCCGAAGCCTTCCTTTATCGCTTTCAGATTTGGAGGCCAATCACTGCCACCTTT
  TATTTCCCTGTGGGTCCAGGAACTGGATTTCTTTATTTGGTCAATTTATATTTCTTATAT
  CAGTATTCTACGCGACTTGAAACAGGAGCTTTTGATGGGAGGCCAGCAGACTATTTATTC
  ATGCTCCTCTTTAACTGGATTTGCATCGTGATTACTGGCTTAGCAATGGATATGCAGTTG
  CTGATGATTCCTCTGATCATGTCAGTACTTTATGTCTGGGCCCAGCTGAACAGAGACATG
  ATTGTATCATTTTGGTTTGGAACACGATTTAAGGCCTGCTATTTACCCTGGGTTATCCTT
  GGATTCAACTATATCATCGGAGGCTCGGTAATCAATGAGCTTATTGGAAATCTGGTTGGA
  CATCTTTATTTTTTCCTAATGTTCAGATACCCAATGGACTTGGGAGGAAGAAATTTTCTA
  TCCACACCTCAGTTTTTGTACCGCTGGCTGCCCAGTAGGAGAGGAGGAGTATCAGGATTT
  GGTGTGCCCCCTGCTAGCATGAGGCGAGCTGCTGATCAGAATGGCGGAGGCGGGAGACAC
  AACTGGGGCCAGGGCTTTCGACTTGGAGACCAGTGA
  
  Clone variation with respect to NM_024295.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_024295 unedited
  TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGCTGGTCCGAATT
  CGGTGGCGCCACGTCCGCCCGTCTCCGCCTTCTGCATCGCGGCTTCGGCGGCTTCCACCT
  AGACACCTAACAGTCGCGGAGCCGGCCGCGTCGTGAGGGGGTCGGCACGGGGAGTCGGGC
  GGTCTTGTGCATCTTGGCTACCTGTGGGTCGAAGATGTCGGACATCGGAGACTGGTTCAG
  GAGCATCCCGGCGATCACGCGCTATTGGTTCGCCGCCACCGTCGCCGTGCCCTTGGTCGG
  CAAACTCGGCCTCATCAGCCCGGCCTACCTCTTCCTCTGGCCCGAAGCCTTCCTTTATCG
  CTTTCAGATTTGGAGGCCAATCACTGCCACCTTTTATTTCCCTGTGGGTCCAGGAACTGG
  ATTTCTTTATTTGGTCAATTTATATTTCTTATATCAGTATTCTACGCGACTTGAAACAGG
  AGCTTTTGATGGGAGGCCAGCAGACTATTTATTCATGCTCCTCTTTAACTGGATTTGCAT
  CGTGATTACTGGCTTAGCAATGGATATGCAGTTGCTGATGATTCCTCTGATCATGTCAGT
  ACTTTATGTCTGGGCCCAGCTGAACAGAGACATGATTGTANTCATTTTGGTTTGGAACAC
  GATTTAAGGCCTGCTATNTACCCCTGGGTTATCCTTGGATTCAACTATATCATCGGAGGG
  CTCGGTAATCAATGAGCTTATTGGAAATCCTGGTTGGACATCTTTATTTTTNCCTAATGT
  CAGATACCCATGGACTTNGNGAGGAAGAAATTTCTATCACAACCTCAATTTTGNNACGCT
  GCTGCCATNGGAGAGGGGAGATTANGGGTNTTTGGGGGGGGCCCCTGCTNCATGAGGCAG
  CTGTGATA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_024295 unedited
  TCCTTTTATTTACAATTTTTACCATAAAAGGATAGTTTACAAAAGGGAAGTCCTTTATAC
  AAAATAAGGATTTTTTTTTTCCATTTGTAAAGAGAATCCACTGTCATGTTTTGCCTTGTC
  AAGTCAAAACTCAAATAGCTTGTTTTGGTAAAATTATTCCAGAAACATAATCCAGACAAA
  ATCAATAACGTCATCAGCTTCCTAACCATGTTTAAGAGGAATAACTTCATGAACATTTTG
  CCCTGAACTGAAGAGTTCTAAATACTTGTAAACCTTTAGGAAAAAATGACTGCTCGCAGG
  CAGCTGACTGGTAAGAGGGTACACCAGAGACTCCGGGTCACTCACTGTCAGAATATTCTT
  ATACATACAATGAGTCTCCACGCCTGTACAATGAGTGTACGTGCAACATAATTGGAGTAA
  TGGCCTCTAAAATTTTACAAGTAAACTTTATTGTGGCCACAGATGAACAACAAAACATGA
  CAGTTAAGGTTCAGACTCTCCCCACCTATTTTATCATATAAATTAAATATGGAGAGGTAC
  ACACAAACTCTATTCAAAATGAGAAGTTGTTTGCCAACTCTCATTTCCTAGGATAACACA
  CATCACACTGTTTAAGAGTGGGGGAAAGAATAGTCATACTGTTAGAGCACAATGTTTCCT
  GAAAAGAAACTGATCAAAACGTTTGAAGCCTTTNTAGTTGCCTCAAAGTGTGACAGCCAC
  TCAATACTGCTCCTAACAGTCTGCTNTCAGATAACGTCATANAATAAATAACTGTGTGAA
  AAGCCATGGCCTTCANNAAACTTATTTGGTTATGAGCCAAGCTCTGATAGGAAAAGCCAC
  CTACGAAAAAAGTGTGGGTATTAAGCTGTCTGATCACAGACTGTCATTATGACTCAAATA
  CACACCTCAACCAAATGATCTAAGCATTCACCTAATATGTATCCCTAGAGTGCTACATAG
  CTTTAAAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_024295
• ORF Size: 756 bp
• Insert Size: 3080
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_024295.3, NP_077271.1
• RefSeq Size: 3033
• RefSeq ORF: 756
• Locus ID: 79139
• Domains: DER1
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS)
• Gene Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]