LIN7C (NM_018362) Human Untagged Clone

CAT#: SC127489

LIN7C (untagged)-Human lin-7 homolog C (C. elegans) (LIN7C)


  "NM_018362" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol LIN7C
Synonyms LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_018362, the custom clone sequence may differ by one or more nucleotides


ATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATATTTGTAGAGCAATTGAATTATTGGAAAAAC
TACAAAGGAGTGGAGAAGTACCACCACAGAAACTTCAGGCTTTGCAAAGAGTCCTTCAAAGTGAATTCTG
CAATGCTGTGAGAGAGGTATATGAACATGTCTATGAGACTGTGGACATCAGTAGCAGTCCTGAAGTGAGA
GCGAACGCTACTGCAAAGGCTACTGTTGCTGCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTG
TTGAGCTACCAAAAACAGAAGAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAACTCTCCAAT
CTATATATCCCGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCTCAAACGTGGAGATCAACTC
CTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGAAAAAGCTGTAGAACTGCTGAAAGCCGCAC
AAGGAAAGGTTAAATTAGTGGTACGATACACACCCAAAGTCTTAGAAGAAATGGAGTCGCGCTTTGAAAA
AATGAGATCAGCAAAACGCAGGCAACAGACCTAA


>OriGene 5' read for NM_018362 unedited
CCGCGAATTCGGCACCAGGATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATAT
TTGTAGAGCAATTGAATTATTGGAAAAACTACAAAGGAGTGGAGAAGTACCACCACAGAA
ACTTCAGGCTTTGCAAAGAGTCCTTCAAAGTGAATTCTGCAATGCTGTGAGAGAGGTATA
TGAACATGTCTATGAGACTGTGGACATCAGTAGCAGTCCTGAAGTGAGAGCGAACGCTAC
TGCAAAGGCTACTGTTGCTGCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTGT
TGAGCTACCAAAAACAGAAGAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAA
CTCTCCAATCTATATATCCCGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCT
CAAACGTGGAGATCAACTCCTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGA
AAAAGCTGTAGAACTGCTGAAAGCCGCACAAGGAAAGGTTAAATTAGTGGTACGATACAC
ACCCAAAGTCTTAGAAGAAATGGAGTCGCGCTTTGAAAAATGAGATCAGCAAAACGCAGG
CAACAGACCTAATACATTTCAAAACTTGATATTTCATTTTGCGTTTTAGCTAGAGAAGTT
TTCCTTGTGACTTACTAATGGCTGCAATGCCAATGATTGNTAGAAAACAACAAATTTATC
ATGAAATTT
Restriction Sites NotI-NotI     
ACCN NM_018362
ORF Size 594 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation A TrueClone.
Reference Data
RefSeq NM_018362.2, NP_060832.1
RefSeq Size 4729
RefSeq ORF 594
Locus ID 55327
Domains PDZ, L27
Protein Families Druggable Genome
Gene Summary Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [UniProtKB/Swiss-Prot Function]

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