LIN7C (NM_018362) Human Untagged Clone

CAT#: SC127489

LIN7C (untagged)-Human lin-7 homolog C (C. elegans) (LIN7C)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LIN7C
• Synonyms: LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_018362, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATATTTGTAGAGCAATTGAATTATTGGAAAAAC
  TACAAAGGAGTGGAGAAGTACCACCACAGAAACTTCAGGCTTTGCAAAGAGTCCTTCAAAGTGAATTCTG
  CAATGCTGTGAGAGAGGTATATGAACATGTCTATGAGACTGTGGACATCAGTAGCAGTCCTGAAGTGAGA
  GCGAACGCTACTGCAAAGGCTACTGTTGCTGCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTG
  TTGAGCTACCAAAAACAGAAGAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAACTCTCCAAT
  CTATATATCCCGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCTCAAACGTGGAGATCAACTC
  CTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGAAAAAGCTGTAGAACTGCTGAAAGCCGCAC
  AAGGAAAGGTTAAATTAGTGGTACGATACACACCCAAAGTCTTAGAAGAAATGGAGTCGCGCTTTGAAAA
  AATGAGATCAGCAAAACGCAGGCAACAGACCTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018362 unedited
  CCGCGAATTCGGCACCAGGATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATAT
  TTGTAGAGCAATTGAATTATTGGAAAAACTACAAAGGAGTGGAGAAGTACCACCACAGAA
  ACTTCAGGCTTTGCAAAGAGTCCTTCAAAGTGAATTCTGCAATGCTGTGAGAGAGGTATA
  TGAACATGTCTATGAGACTGTGGACATCAGTAGCAGTCCTGAAGTGAGAGCGAACGCTAC
  TGCAAAGGCTACTGTTGCTGCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTGT
  TGAGCTACCAAAAACAGAAGAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAA
  CTCTCCAATCTATATATCCCGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCT
  CAAACGTGGAGATCAACTCCTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGA
  AAAAGCTGTAGAACTGCTGAAAGCCGCACAAGGAAAGGTTAAATTAGTGGTACGATACAC
  ACCCAAAGTCTTAGAAGAAATGGAGTCGCGCTTTGAAAAATGAGATCAGCAAAACGCAGG
  CAACAGACCTAATACATTTCAAAACTTGATATTTCATTTTGCGTTTTAGCTAGAGAAGTT
  TTCCTTGTGACTTACTAATGGCTGCAATGCCAATGATTGNTAGAAAACAACAAATTTATC
  ATGAAATTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018362
• ORF Size: 594 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: A TrueClone.

Reference Data

• RefSeq: NM_018362.2, NP_060832.1
• RefSeq Size: 4729
• RefSeq ORF: 594
• Locus ID: 55327
• Domains: PDZ, L27
• Protein Families: Druggable Genome
• Gene Summary: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [UniProtKB/Swiss-Prot Function]