Neurexin 1 (NRXN1) (NM_004801) Human Untagged Clone

CAT#: SC127539

NRXN1 (untagged)-Human neurexin 1 (NRXN1), transcript variant alpha1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NRXN1
• Synonyms: Hs.22998; PTHSL2; SCZD17
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004801, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTCCTGGGCTGCT
  GGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAA
  CGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTC
  GACGACGAGGGCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
  CCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGT
  GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTC
  AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCGGAACTGCGCG
  CCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTCAAGGGGTGGATTCGTGACGT
  GAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGCGAGGTGAAGCTGGACGATGAGCCGCCCAAC
  AGCGGCGGGGGAAGCCCGTGCGAGGCGGGCGAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGT
  GCTCCGTGGTGGACGACCAGGCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCA
  AGAAGACAACAATGTGGAAGGTCTGGCGCACCTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAA
  GAATATATTGCCACGTTCAAAGGATCTGAATACTTCTGCTACGACTTGTCTCAAAACCCCATTCAAAGCA
  GCAGTGATGAAATAACTCTGTCATTTAAAACCCTTCAGAGGAATGGACTGATGCTTCACACTGGGAAATC
  GGCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCC
  TTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCA
  GGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTGACAATATCAGTGGATGGGATTCTTACCAC
  AACGGGCTACACGCAAGAAGATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCC
  AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTTGTATATA
  AAAATAATGATGTGAGGCTGGAATTATCTCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATCCATGG
  AGTGGTGGCATTTAAATGTGAGAATGTTGCAACTTTAGACCCAATCACCTTTGAAACCCCAGAGTCTTTC
  ATCTCTTTGCCTAAATGGAATGCAAAGAAAACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAA
  ATGGCCTCATCTTATTTAGCCATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAA
  GGTGGACTTCTTTGCTATTGAGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACT
  ATAAAAATAAAAGCCCTGTTGAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTCCAGAGAGACG
  GACGGTCAGGTACCATTTCTGTCAACACGTTGCGTACTCCCTACACTGCTCCTGGTGAGAGTGAGATTCT
  GGACCTGGATGATGAGTTGTACCTGGGGGGGCTGCCAGAAAATAAAGCTGGCCTTGTCTTCCCCACCGAG
  GTGTGGACTGCTCTGCTCAACTATGGCTACGTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCA
  AAGATATCCGGCAAATGGCTGAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGC
  AAAACCGTGCCTTAGCAACCCTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGT
  GATTGTTCCGGAACAGGCTATCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTATGATGGGA
  GCATGTTTATGAAAATTCAGCTCCCCGTAGTCATGCATACGGAGGCTGAGGATGTTTCCTTACGGTTCCG
  ATCCCAGCGTGCATATGGCATTCTGATGGCAACCACTTCTAGAGACTCTGCTGACACCCTCCGCCTGGAG
  CTAGACGCAGGACGTGTGAAACTGACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAG
  GTCCCGAGACTCTTTTTGCTGGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCG
  TGGAAAAAGTTTAAAGTTAACAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACT
  AGGCTGGAGTTCCATAACATAGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCTGTCCCCTCCA
  ACTTCATTGGACACCTGCAGAGCTTGACATTTAATGGAATGGCATACATTGACCTGTGTAAAAATGGCGA
  CATAGATTACTGTGAGCTTAATGCCAGATTTGGCTTCAGGAACATCATAGCAGATCCTGTCACCTTCAAG
  ACCAAATCGAGCTATGTTGCCTTAGCTACCTTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCA
  AGACAACATCCCTAGATGGATTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATT
  AGTTAAAGGGTACTTACATTACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAAT
  AAACCTCTCAATGACAATCAGTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTCCACACTGTAA
  AGATTGACACAAAAATCACAACGCAAATCACCGCCGGAGCCAGGAACTTAGACCTCAAGAGTGACTTATA
  TATAGGAGGAGTAGCTAAAGAAACATACAAATCCTTACCAAAACTTGTACATGCCAAAGAAGGCTTTCAA
  GGCTGCCTGGCATCAGTTGATTTAAATGGACGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACG
  GACAGATCGAGAGAGGATGTGAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGT
  GTGCTTGCAACAATGGGATGGCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAAT
  GACCCTGGGACGACATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCTCCTAATGACC
  GACCCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAGAAAGAAGCCGTATTGGTGCG
  AGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTGCATATACACCAGGGAAAAATTGGAGTTAAG
  TTTAATGTTGGGACAGATGACATCGCCATTGAAGAATCCAATGCAATCATTAATGATGGGAAATACCATG
  TAGTTCGTTTCACGAGGAGTGGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTA
  CCCTGCAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGC
  CAGCCCTTCCAGGGCCAGCTCTCTGGGCTGTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAA
  ACGATGCCAACATCGCCATAGTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGA
  GTCAACAGCCACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACT
  AGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGACATCCTTGTGG
  CCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAA
  CCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCAGCAGAAGTGATCCGGGAGTCCAGCAGCACC
  ACGGGTATGGTCGTTGGGATAGTAGCCGCTGCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACA
  AGTACAGAAACCGGGATGAAGGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACA
  GTCCAATGGGGCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAAC
  AAGGATAAAGAGTATTATGTCTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004801 unedited
  CCCCCCCCCNNNNNCCNCCCNCCTTTTCCCCCCCNCNNGGTTCGGAATTTGTNATACCAC
  TCACTATAGGCGGCCGCGNAATTCGCACGNAGGNANANANAGAGAGAGAGAGAACTAGAT
  AAAGGAGGGCACATCCCTCTCACTCCCGCCTTTCCCCTTACCTTTCTGTCTCTCGGGACC
  CTTATTTCTTCGTCACGGTGTCCAGGACCATTTTGACCCTGTCGGCCCCGGCACCCCCCC
  GCCGCACCCCAGCCCCGAGCATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTC
  TGTGCCTCTCGCTGCTGCTCCTGGGCTGCTGGGCGGAGCTGGGCAGCGGGCTGGAGTTTC
  CGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAACGCCTGCTGCGAGAGCGAGA
  TGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTCGACGACGAGG
  GCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
  CCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCT
  GGCACAGCGTGCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGG
  AGGCCAAGTGGGTGGAGGTCAAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTT
  TCGTCGGGGGGCTGCCCCCGGAACTGCGCGCCGCGGCGCTCAAGCTCACCTTGGCCTCGG
  TGAGGGAGCGGGAGCCCTTCAGGGGTGGATTCGNGACGTGAGGGCACCTCCTCGCAGGTC
  TGCCCCGTGACAGGGCGAGGTGAAGCTGGACGATGACCCCCCAACACCGGCGGGGAAGCC
  CCCTCTAGCGGCCCAGAGGGCCAGGCCCGGGTGTGCCTTAACGGGGGGGGTGCTCCGGGG
  GGACCACCAGCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004801 unedited
  TTTTTATGTACCGCGGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGAGAAAC
  AAGACATGAGATACTTGTTTTTATTTTTTAAAAAGTCTTTCCTTCCTGATTGCATTCCCT
  GTCTTCTTTTGTATGTGCTTCATAAAAAGGAAAGTAAATAAGTTTATATTATGTCTCAGA
  TAAAATGAAGACTATTTCTATACAAGTGTCCATTTAAGATCTTGGGATCAGACATAATAC
  TCTTTATCCTTGTTTTTCTTATTTTTGTTGGAGCTTTTCGCACTGCTGGGTTGTTTCTCC
  TTTACAACAGCCCCATTGGACTGTGCTGAGTTACTGATGTAGTTTCGACTCTCGTCCACA
  TGGTATGAGCCTTCATCCCGGTTTCTGTACTTGTACATGGCATAGAGGAGGATAAGGATG
  CACAGGGCGGCAGCGGCTACTATCCCAACGACCATACCCGTGGTGCTGCTGGACTCCCGG
  ATCACTTCTGCTGAGCCTGGATACGGCTCTCTGCCGCCTGCTCGGGTTGGGTTGGCTGAC
  CTCGGCTCACAGGGGACAATGCCCTCATCATCGCTGGGACCCTCTGCTGAGGCCCCAGGA
  TGACATCTGCGGACTGGCTAATGGGATCCTTTGCCGGGGCCCACCCCTTGTGCTGCGCTA
  ACCACCCGGATATGGTAACCCCATCATGCATGGGACAACACGTGACGCAAGGCAATGCCT
  CGTGACTTCCCTGTCGAAAGCAAGCCCTTCGGCGACCAGCCCCCCTCGTCCTTTAGGGGG
  ATGTATCTTTCTCTCATCGCCCATCCCCACTACCCACCCTTGTGTACCCCTCTCCCACCC
  TTACCACTAGGACGAACCTTATTTCCCCCCCTACGTTCCGCCCGCCGCCATCTCAAAGCC
  AACCCCGCGTCCTCCCGCCCCGCCCCCCCTCTACCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004801
• ORF Size: 4434 bp
• Insert Size: 4470
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004801.2, NP_004792.1
• RefSeq Size: 9368
• RefSeq ORF: 4434
• Locus ID: 9378
• Domains: LamG, EGF, EGF
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• Gene Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
  Transcript Variant: This variant (alpha1) results from the use of the 5'-most promoter, referred to as alpha. It lacks two in-frame exons and uses an alternate in-frame donor splice site at an internal exon compared to variant alpha2. The resulting isoform (alpha1) is shorter missing a few internal protein segments compared to isoform alpha2. This isoform contains EGF-like, several laminin G, and syndecan domains. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.