Neurexin 1 (NRXN1) (NM_004801) Human Untagged Clone

CAT#: SC127539

NRXN1 (untagged)-Human neurexin 1 (NRXN1), transcript variant alpha1


  "NM_004801" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NRXN1
Synonyms Hs.22998; PTHSL2; SCZD17
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_004801, the custom clone sequence may differ by one or more nucleotides


ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTCCTGGGCTGCT
GGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAA
CGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTC
GACGACGAGGGCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
CCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGT
GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTC
AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCGGAACTGCGCG
CCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTCAAGGGGTGGATTCGTGACGT
GAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGCGAGGTGAAGCTGGACGATGAGCCGCCCAAC
AGCGGCGGGGGAAGCCCGTGCGAGGCGGGCGAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGT
GCTCCGTGGTGGACGACCAGGCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCA
AGAAGACAACAATGTGGAAGGTCTGGCGCACCTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAA
GAATATATTGCCACGTTCAAAGGATCTGAATACTTCTGCTACGACTTGTCTCAAAACCCCATTCAAAGCA
GCAGTGATGAAATAACTCTGTCATTTAAAACCCTTCAGAGGAATGGACTGATGCTTCACACTGGGAAATC
GGCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCC
TTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCA
GGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTGACAATATCAGTGGATGGGATTCTTACCAC
AACGGGCTACACGCAAGAAGATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCC
AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTTGTATATA
AAAATAATGATGTGAGGCTGGAATTATCTCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATCCATGG
AGTGGTGGCATTTAAATGTGAGAATGTTGCAACTTTAGACCCAATCACCTTTGAAACCCCAGAGTCTTTC
ATCTCTTTGCCTAAATGGAATGCAAAGAAAACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAA
ATGGCCTCATCTTATTTAGCCATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAA
GGTGGACTTCTTTGCTATTGAGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACT
ATAAAAATAAAAGCCCTGTTGAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTCCAGAGAGACG
GACGGTCAGGTACCATTTCTGTCAACACGTTGCGTACTCCCTACACTGCTCCTGGTGAGAGTGAGATTCT
GGACCTGGATGATGAGTTGTACCTGGGGGGGCTGCCAGAAAATAAAGCTGGCCTTGTCTTCCCCACCGAG
GTGTGGACTGCTCTGCTCAACTATGGCTACGTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCA
AAGATATCCGGCAAATGGCTGAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGC
AAAACCGTGCCTTAGCAACCCTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGT
GATTGTTCCGGAACAGGCTATCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTATGATGGGA
GCATGTTTATGAAAATTCAGCTCCCCGTAGTCATGCATACGGAGGCTGAGGATGTTTCCTTACGGTTCCG
ATCCCAGCGTGCATATGGCATTCTGATGGCAACCACTTCTAGAGACTCTGCTGACACCCTCCGCCTGGAG
CTAGACGCAGGACGTGTGAAACTGACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAG
GTCCCGAGACTCTTTTTGCTGGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCG
TGGAAAAAGTTTAAAGTTAACAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACT
AGGCTGGAGTTCCATAACATAGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCTGTCCCCTCCA
ACTTCATTGGACACCTGCAGAGCTTGACATTTAATGGAATGGCATACATTGACCTGTGTAAAAATGGCGA
CATAGATTACTGTGAGCTTAATGCCAGATTTGGCTTCAGGAACATCATAGCAGATCCTGTCACCTTCAAG
ACCAAATCGAGCTATGTTGCCTTAGCTACCTTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCA
AGACAACATCCCTAGATGGATTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATT
AGTTAAAGGGTACTTACATTACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAAT
AAACCTCTCAATGACAATCAGTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTCCACACTGTAA
AGATTGACACAAAAATCACAACGCAAATCACCGCCGGAGCCAGGAACTTAGACCTCAAGAGTGACTTATA
TATAGGAGGAGTAGCTAAAGAAACATACAAATCCTTACCAAAACTTGTACATGCCAAAGAAGGCTTTCAA
GGCTGCCTGGCATCAGTTGATTTAAATGGACGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACG
GACAGATCGAGAGAGGATGTGAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGT
GTGCTTGCAACAATGGGATGGCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAAT
GACCCTGGGACGACATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCTCCTAATGACC
GACCCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAGAAAGAAGCCGTATTGGTGCG
AGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTGCATATACACCAGGGAAAAATTGGAGTTAAG
TTTAATGTTGGGACAGATGACATCGCCATTGAAGAATCCAATGCAATCATTAATGATGGGAAATACCATG
TAGTTCGTTTCACGAGGAGTGGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTA
CCCTGCAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGC
CAGCCCTTCCAGGGCCAGCTCTCTGGGCTGTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAA
ACGATGCCAACATCGCCATAGTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGA
GTCAACAGCCACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACT
AGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGACATCCTTGTGG
CCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAA
CCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCAGCAGAAGTGATCCGGGAGTCCAGCAGCACC
ACGGGTATGGTCGTTGGGATAGTAGCCGCTGCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACA
AGTACAGAAACCGGGATGAAGGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACA
GTCCAATGGGGCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAAC
AAGGATAAAGAGTATTATGTCTGA


>OriGene 5' read for NM_004801 unedited
CCCCCCCCCNNNNNCCNCCCNCCTTTTCCCCCCCNCNNGGTTCGGAATTTGTNATACCAC
TCACTATAGGCGGCCGCGNAATTCGCACGNAGGNANANANAGAGAGAGAGAGAACTAGAT
AAAGGAGGGCACATCCCTCTCACTCCCGCCTTTCCCCTTACCTTTCTGTCTCTCGGGACC
CTTATTTCTTCGTCACGGTGTCCAGGACCATTTTGACCCTGTCGGCCCCGGCACCCCCCC
GCCGCACCCCAGCCCCGAGCATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTC
TGTGCCTCTCGCTGCTGCTCCTGGGCTGCTGGGCGGAGCTGGGCAGCGGGCTGGAGTTTC
CGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAACGCCTGCTGCGAGAGCGAGA
TGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTCGACGACGAGG
GCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
CCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCT
GGCACAGCGTGCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGG
AGGCCAAGTGGGTGGAGGTCAAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTT
TCGTCGGGGGGCTGCCCCCGGAACTGCGCGCCGCGGCGCTCAAGCTCACCTTGGCCTCGG
TGAGGGAGCGGGAGCCCTTCAGGGGTGGATTCGNGACGTGAGGGCACCTCCTCGCAGGTC
TGCCCCGTGACAGGGCGAGGTGAAGCTGGACGATGACCCCCCAACACCGGCGGGGAAGCC
CCCTCTAGCGGCCCAGAGGGCCAGGCCCGGGTGTGCCTTAACGGGGGGGGTGCTCCGGGG
GGACCACCAGCG
>OriGene 3' read for NM_004801 unedited
TTTTTATGTACCGCGGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGAGAAAC
AAGACATGAGATACTTGTTTTTATTTTTTAAAAAGTCTTTCCTTCCTGATTGCATTCCCT
GTCTTCTTTTGTATGTGCTTCATAAAAAGGAAAGTAAATAAGTTTATATTATGTCTCAGA
TAAAATGAAGACTATTTCTATACAAGTGTCCATTTAAGATCTTGGGATCAGACATAATAC
TCTTTATCCTTGTTTTTCTTATTTTTGTTGGAGCTTTTCGCACTGCTGGGTTGTTTCTCC
TTTACAACAGCCCCATTGGACTGTGCTGAGTTACTGATGTAGTTTCGACTCTCGTCCACA
TGGTATGAGCCTTCATCCCGGTTTCTGTACTTGTACATGGCATAGAGGAGGATAAGGATG
CACAGGGCGGCAGCGGCTACTATCCCAACGACCATACCCGTGGTGCTGCTGGACTCCCGG
ATCACTTCTGCTGAGCCTGGATACGGCTCTCTGCCGCCTGCTCGGGTTGGGTTGGCTGAC
CTCGGCTCACAGGGGACAATGCCCTCATCATCGCTGGGACCCTCTGCTGAGGCCCCAGGA
TGACATCTGCGGACTGGCTAATGGGATCCTTTGCCGGGGCCCACCCCTTGTGCTGCGCTA
ACCACCCGGATATGGTAACCCCATCATGCATGGGACAACACGTGACGCAAGGCAATGCCT
CGTGACTTCCCTGTCGAAAGCAAGCCCTTCGGCGACCAGCCCCCCTCGTCCTTTAGGGGG
ATGTATCTTTCTCTCATCGCCCATCCCCACTACCCACCCTTGTGTACCCCTCTCCCACCC
TTACCACTAGGACGAACCTTATTTCCCCCCCTACGTTCCGCCCGCCGCCATCTCAAAGCC
AACCCCGCGTCCTCCCGCCCCGCCCCCCCTCTACCC
Restriction Sites NotI-NotI     
ACCN NM_004801
ORF Size 4434 bp
Insert Size 4470
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_004801.2, NP_004792.1
RefSeq Size 9368
RefSeq ORF 4434
Locus ID 9378
Domains LamG, EGF, EGF
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
Gene Summary This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
Transcript Variant: This variant (alpha1) results from the use of the 5'-most promoter, referred to as alpha. It lacks two in-frame exons and uses an alternate in-frame donor splice site at an internal exon compared to variant alpha2. The resulting isoform (alpha1) is shorter missing a few internal protein segments compared to isoform alpha2. This isoform contains EGF-like, several laminin G, and syndecan domains. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

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