MTGR1 (CBFA2T2) (NM_175864) Human Untagged Clone

CAT#: SC127577

CBFA2T2 (untagged)-Human core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (CBFA2T2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBFA2T2
• Synonyms: core-binding factor, runt domain, alpha subunit 2; DKFZp313F2116; EHT; EHT, MTGR1, ZMYND3, DKFZp313F2116; ETO homolog on chromosome 20; MTG8-like protein; MTGR1; myeloid translocation gene-related protein 1; OTTHUMP00000030653; translocated to, 2; ZMYND3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127577 sequence for NM_175864 edited (data generated by NextGen Sequencing)
  ATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCA
  CCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCATTA
  AGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGA
  TTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCC
  ACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAGTTT
  GGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTG
  AACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCC
  CTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTG
  CTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACAC
  CTTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTG
  CACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGAGAC
  ACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCAC
  AGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCA
  CCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCCAAC
  AAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGC
  TATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAA
  CATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCTATG
  GCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGG
  TACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGC
  CCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCAGGT
  ACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAA
  ATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAA
  GTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAGGCC
  GCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAAC
  TGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCT
  TTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGC
  CAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGG
  TCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGT
  TCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGA
  
  Clone variation with respect to NM_175864.1
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_175864 unedited
  TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTCTGGTTAGCTCGG
  CGGCTGCAGATCTCGCGGCGACGCCTGCGAGGGACCCGGGCCGCGGGTCGAGGCGGGCGG
  CGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
  GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCTTGGTCCTGAGAAAAGGGTGCCAGC
  GATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCC
  ACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCATT
  AAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAG
  ATTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGC
  CACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAGTT
  TGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGT
  GAACTCAACAGTGACCATTGAGGAATTCCACTGGTAGCTCCAAGAAGCCACAAACTTTCC
  CCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAACT
  GCTGCACTGCGCTCGGGCGGNCCAGCAGACCCCATCCAGTACCTGGCTCAGCACGAACAC
  CTTTCTGCTCACACAAGCATTGCATCGCCTGCTGACTCGTCANAGNTGCTCATGGGAGTG
  CACGGNNATGGGGAGAGGCCCANTCCAGAGAGGAGAGAGAGAATAGTTTGATAGAGCACA
  TTTGCTCCTGAGCCTCTGGCCAGAGAGTATGACCATCAGCCTGCTCTCGGACAGTCTGTT
  TTCTGGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_175864 unedited
  CGCGCCGCTTTCTAGTATCGAGTTTTTTTTTTTTTTTTTTGTGATGTGGGGGAAGTTTTA
  TTTGTTTTATGTTTTTGCTACTACGGGTGCTTTTATTGCAACAGTGACTTCTTTCCTGTG
  GACTCTGAGATCTTATCAAGTCTGAACAGCAGGGTTGAGAAGAGTCCTGAATGCCGCCTG
  TTGCTTACCCAAGTCCCCGTGAGGCCAATCAGTGTCATCTGCTGAGGATGGAGATGGGGC
  CGAAGGAGCTATTCAAGGGTGAGGCAGGCCGCTCCCTGACCGAAGGGCCTTCTACACAGC
  CTGCTGCCTGCCGCCTGCCGCCTCCAGCCTGGCTGAGCACATTGGACAGTCTGCTGACTC
  AAGGAGATGGGGAGGGGAGCTGGTGGTCTACACTGAAAAGGGGCCGGCTAAGTCAGCTTC
  AGTGGAGAGAGGAACAAACCAGGAAAGCCATGGAGGAGGCAGCTCAAGCTGGCTGCCCAT
  GTGCAGAGAATGGCACACTGGCTCCGCAGACAGCAAGTGCACAGAGAGGCTGCGGGGTGT
  TATTATTCAAGCTTGGACTCTTCCTGCCTCCAATTCATTTCTTGCCTGATGACCCGGCAG
  CTACATGCACGGGTTCCAACAGTCAGTCCCTCAGCCAAGCACCTCTGAGGTGCTGAGCAG
  CCATCATGGTTAGCAGAGTCCGTGGCTCATAGTCCCGTTGGTGTCGATAGCCTGTCACAG
  AACCAGTTGCTGAGGAACGCCATGTGGTTGCCGAGGTCTTGTCGAGGCCTTGGCTGGCAC
  GCCTGATTGGCGGACCTGTGAAAGGACCCCCTGCCTACAGAAGCAATAGCCGCCCCTGCC
  CGTGAGGCTTTGCCCTGCAGGTCTGACCACAGATCGGTGTGCCGCTCCAGTCTTGGCTGG
  AAAAAAGCACATTTGGCGAATTGGAGCCTGTTGTTTGCTGCTGGGCCCATTCCACATTTT
  CCGGACTCCTTGCCAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_175864
• ORF Size: 6996 bp
• Insert Size: 2440
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_175864.1, NP_787060.1
• RefSeq Size: 6996
• RefSeq ORF: 6996
• Locus ID: 9139
• Protein Families: Transcription Factors
• Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (MTGR1a).