Frizzled 2 (FZD2) (NM_001466) Human Untagged Clone

CAT#: SC127603

FZD2 (untagged)-Human frizzled family receptor 2 (FZD2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FZD2
• Synonyms: fz-2; Fz2; fzE2; hFz2; OMOD2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001466 edited
  GAATTCGGCACGAGGGGAGAGAGGGCAGCAGCGCGCGGTGTCTCCGGCTGCTCAGTCCGA
  CCGCGGCAAGCAAGCGGGCAGGCGCACCGCCCCCTCCCCCGCCCGGCCTCCCCAACTCTG
  CGGCCGCGAGTAAAGTTTGCAAAGAGGCGCGGGAGGCGGCAGCCGCAGCGAGGAGGCGGC
  GGGGAAGAAGCGCAGTCTCCGGGTTGGGGGCGGGGGCGGGGGGGGCGCCAAGGAGCCGGG
  TGGGGGGCGGCGGCCAGCATGCGGCCCCGCAGCGCCCTGCCCCGCCTGCTGCTGCCGCTG
  CTGCTGCTGCCCGCCGCCGGGCCGGCCCAGTTCCACGGGGAGAAGGGCATCTCCATCCCG
  GACCACGGCTTCTGCCAGCCCATCTCCATCCCGCTGTGCACGGACATCGCCTACAACCAG
  ACCATCATGCCCAACCTTCTGGGCCACACGAACCAGGAGGACGCAGGCCTAGAGGTGCAC
  CAGTTCTATCCGCTGGTGAAGGTGCAGTGCTCGCCCGAACTGCGCTTCTTCCTGTGCTCC
  ATGTACGCACCCGTGTGCACCGTGCTGGAACAGGCCATCCCGCCGTGCCGCTCTATCTGT
  GAGCGCGCGCGCCAGGGCTGCGAAGCCCTCATGAACAAGTTCGGTTTTCAGTGGCCCGAG
  CGCCTGCGCTGCGAGCACTTCCCGCGCCACGGCGCCGAGCAGATCTGCGTCGGCCAGAAC
  CACTCCGAGGACGGAGCTCCCGCGCTACTCACCACCGCGCCGCCGCCGGGACTGCAGCCG
  GGTGCCGGGGGCACCCCGGGTGGCCCGGGCGGCGGCGGCGCTCCCCCGCGCTACGCCACG
  CTGGAGCACCCCTTCCACTGCCCGCGCGTCCTCAAGGTGCCATCCTATCTCAGCTACAAG
  TTTCTGGGCGAGCGTGATTGTGCTGCGCCCTGCGAACCTGCGCGGCCCGATGGTTCCATG
  TTCTTCTCACAGGAGGAGACGCGTTTCGCGCGCCTCTGGATCCTCACCTGGTCGGTGCTG
  TGCTGCGCTTCCACCTTCTTCACTGTCACCACGTACTTGGTAGACATGCAGCGCTTCCGC
  TACCCAGAGCGGCCTATCATTTTTCTGTCGGGCTGCTACACCATGGTGTCGGTGGCCTAC
  ATCGCGGGCTTCGTGCTCCAGGAGCGCGTGGTGTGCAACGAGCGCTTCTCCGAGGACGGT
  TACCGCACGGTGGTGCAGGGCACCAAGAAGGAGGGCTGCACCATCCTCTTCATGATGCTC
  TACTTCTTCAGCATGGCCAGCTCCATCTGGTGGGTCATCCTGTCGCTCACCTGGTTCCTG
  GCAGCCGGCATGAAGTGGGGCCACGAGGCCATCGAGGCCAACTCTCAGTACTTCCACCTG
  GCCGCCTGGGCCGTGCCGGCCGTCAAGACCATCACCATCCTGGCCATGGGCCAGATCGAC
  GGCGACCTGCTGAGCGGCGTGTGCTTCGTAGGCCTCAACAGCCTGGACCCGCTGCGGGGC
  TTCGTGCTAGCGCCGCTCTTCGTGTACCTGTTCATCGGCACGTCCTTCCTCCTGGCCGGC
  TTCGTGTCGCTCTTCCGCATCCGCACCATCATGAAGCACGACGGCACCAAGACCGAAAAG
  CTGGAGCGGCTCATGGTGCGCATCGGCGTCTTCTCCGTGCTCTACACAGTGCCCGCCACC
  ATCGTCATCGCTTGCTACTTCTACGAGCAGGCCTTCCGCGAGCACTGGGAGCGCTCGTGG
  GTGAGCCAGCACTGCAAGAGCCTGGCCATCCCGTGCCCGGCGCACTACACGCCGCGCATG
  TCGCCCGACTTCACGGTCTACATGATCAAATACCTCATGACGCTCATCGTGGGCATCACG
  TCGGGCTTCTGGATCTGGTCGGGCAAGACGCTGCACTCGTGGAGGAAGTTCTACACTCGC
  CTCACCAACAGCCGACACGGTGAGACCACCGTGTGAGGGACGCCCCCAGGCCGGAACCGC
  GCGGCGCTTTCCTCCGCCCGGGGTGGGGCCCCTACAGACTCCGTATTTTATTTTTTTAAA
  TAAAAAACGATCGAAACCATTTCACTTTTAGGTTGCTTTTTAAAAGAGAACTCTCTGCCC
  AACACCCCCACAAGGTTTGTAATTAAAACTGTAAATAGTCTTTGTAAATTTAATTATATA
  TATTTTCTATTTAAAAGAAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001466 unedited
  GGTCGGATTTTGTATACGACTTCACTATAGGGCGGCCGCGATTCGGCACGAGGGGAGAGA
  GGGCAGCAGCGCGCGGTGTCTCCGGCTGCTCAGTCCGACCGCGGCAAGCAAGCGGGCAGG
  CGCACCGCCCCCTCCCCCGCCCGGCCTCCCCAACTCTGCGGCCGCGAGTAAAGTTTGCAA
  AGAGGCGCGGGAGGCGGCAGCCGCAGCGAGGAGGCGGCGGGGAAGAAGCGCAGTCTCCGG
  GTTGGGGGCGGGGGCGGGGGGGGCGCCAAGGAGCCGGGTGGGGGGGCGGNNNNNNNNNTN
  TNNNTTNTNNNNNNNNTTTNNTNTTNNTTTTTTTGTNTTTTNTNTTTTTTTTTTTTTTNN
  NTTNNNNNNNTTTNTTTNNNNTTGGNNNTTTTNNTTNTTNNTTTTTTTTTTTNTTTTNNN
  TTNNTTTTTTTTTTTTTNNTTTTTTTTTTTTTNNTTTTTTNNNTTTTTTTTTTTTTTTTT
  TTTTNTTNNTNNTTTNNTTTTTTTTTTTTTTTNTNTTNTTNNTTTTTNNNNNTTNTTTTT
  TTTTTTTTTTTTTTTTTTTTNTTTTTTTTTTGGTTTTTTTTTTTTTTTTTTNNNTTTTTC
  CTTTTTTTTTNTTTTTTTTTTTNTTTTTTTTTNNTTTTTTTTNTTTTTTTTTTTTTTTTT
  TCTTTTTTTTTNTNNTTNTTTTTTTTTTTTTTTNNNNTTNNTTTTNTTTTTTTTTTTNTT
  TTTTNTTTTTTTNNTNTTTTTTTTTTTTTTTTTTTTTTTTNTTTNNTTTNNTTTTTTTTT
  TTTTTTTTTTTTNNTTTTTTTTTTTTNNNTTTTTTTTNNTTTTTTTTTTTTTTTNTTTTN
  TNNTTTNNNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTTTNTTTTTTTTTTTTTNNT
  TNNNTTTTTTTTCCTCCTTTTTTTTTTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001466 unedited
  CGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTCTTTTAAATAGAAAATATAT
  ATAATTAAATTTACAAAGACTATTTACAGTTTTAATTACAAACCTTGTGGGGGTGTTGGG
  CAGAGAGTTCTCTTTTAAAAAGCAACCTAAAAGTGAAATGGTTTCGATCGTTTTTTATTT
  AAAAAAATAAAATACGGAGTCTGTAGGGGCCCCACCCCGGGCGGAGGAAAGCGCCGCGCG
  GTTCCGGCCTGGGGGCGTCCCTCACACGGTGGTCTCACCGTGTCGGCTGTTGGTGAGGCG
  AGTGTAAAACTTCCTCCACGAGTGCAGCGTCTTGCCCGACCAGATCCAGAAGCCCGACGT
  GATGCCCACGATGAGCGTCATGAGGTATTTGATCATGTAGACCGTGAAGTCGGGCGACAT
  GCGCGGCGTGTAGTGCGCCGGGCACGGGATGGCCAGGCTCTTGCAGTGCTGGCTCACCCA
  CGAGCGCTTCCAGTGCTCGCGGAAGGCCTGCTCGTAAAAGTAGCAAGCGATGACGATGGT
  GGGCGGCACTGTGTAGAGCACGGAGAAGACGCCGATGCGCACCATGAGCCCGCTCAGCTT
  TTCGGTCTTGGTGCCGTCGTGCTTCATGATGGGTGCGATGCCGAAGAGCGACACGAAGCC
  GCCCAGAGGAAGACGTGCCCATGACAAGTACACGAAGAAGCGCGCTAGCACGAACCCCGC
  AGGGGTCCAGCCTGTTGAGCCTACGAGCACACGCCGTTCACAAGTCGCCGTCATCTGCCA
  TGGCCAGATGGGATTGTCTTGAAGCGGCCGCCCAGGCGGCAGGGGAGTACTGAAGTTGCC
  CTCATTGCTCGTGGCCCACTTATGCCGGTTGCGGAACCCGGTGAGGAAGGATGACCCACA
  ATGAGCTGCCTGCTGAAAAGTAACCTCTGAAAGGATGGGCCCCCTTTTTTTGGCCCTGCC
  CACGGCGGGAACCGTCTGGAAAAGCTGTTGCACCCCCCCTTCGGAACCAAACCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001466
• Insert Size: 2170 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001466.2, NP_001457.1
• RefSeq Size: 1983 bp
• RefSeq ORF: 1698 bp
• Locus ID: 2535
• Cytogenetics: 17q21.31
• Domains: FRI, Frizzled
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
• Gene Summary: 'This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]'