Dysadherin (FXYD5) (NM_144779) Human Untagged Clone

CAT#: SC127643

FXYD5 (untagged)-Human FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FXYD5
• Synonyms: DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_144779, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTCGCCCTCTGGTCGCCTGTGTCTTCTCACCATCGTTGGCCTGATTCTCCCCACCAGAGGACAGACGT
  TGAAAGATACCACGTCCAGTTCTTCAGCAGACTCAACTATCATGGACATTCAGGTCCCGACACGAGCCCC
  AGATGCAGTCTACACAGAACTCCAGCCCACCTCTCCAACCCCAACCTGGCCTGCTGATGAAACACCACAA
  CCCCAGACCCAGACCCAGCAACTGGAAGGAACGGATGGGCCTCTAGTGACAGATCCAGAGACACACAAGA
  GCACCAAAGCAGCTCATCCCACTGATGACACCACGACGCTCTCTGAGAGACCATCCCCAAGCACAGACGT
  CCAGACAGACCCCCAGACCCTCAAGCCATCTGGTTTTCATGAGGATGACCCCTTCTTCTATGATGAACAC
  ACCCTCCGGAAACGGGGGCTGTTGGTCGCAGCTGTGCTGTTCATCACAGGCATCATCATCCTCACCAGTG
  GCAAGTGCAGGCAGCTGTCCCGGTTATGCCGGAATCGTTGCAGGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_144779 unedited
  TGCAGAATTTTGTAATACGACTCACTCATAGGGCGGCCGCGAATTCGCACGAGGCCACCG
  CCGCGTCCCTCTCTCCACGAGCTGCCGGCTTAGGACCCCCAGCTCCGACCATCGCCTGGT
  CCCACAGATGTCGCCCTCTGGTCGCCTGTGTCTTCTCACCATCGTTGGCCTGATTCTCCC
  CACCAGAGGACAGACGTTGAAAGATACCACGTCCAGTTCTTCAGCAGACTCAACTATCAT
  GGACATTCAGGTCCCGACACGAGCCCCAGATGCAGTCTACACAGAACTCCAGCCCACCTC
  TCCAACCCCAACCTGGCCTGCTGATGAAACACCACAACCCCAGACCCAGACCCAGCAACT
  GGAAGGAACGGATGGGCCTCTAGTGACAGATCCAGAGACACACAAGAGCACCAAAGCAGC
  TCATCCCACTGATGACACCACGACGCTCTCTGAGAGACCATCCCCAAGCACAGACGTCCA
  GACAGACCCCCAGACCCTCAAGCCATCTGGTTTTCATGAGGATGACCCCTTCTTCTATGA
  TGAACACACCCTCCGGAAACGGGGCTGTTGGTCGCAGCTGTGCTGTTCATCACAGGCATC
  ATCATCCTCACCAGTGGCAAGTGCAGGCAGCTGTCCCGGTTATGCCGGAATCATTGCAGG
  TGAGTCCATCAGATACAGGAGCTGNACACCCGCTGGGCACCCGAAGACCAAGCCCNCTGC
  CAGCTCACCGTGCCCAGCCTCCTGCATCCNCTCGAAGAGCCTGGCCAGAGAGGGAAGACA
  CAGATGATGAATCTGGAGCCAGGGCTGNNCGTTCGAGTTNCCTACCTTCCCCATCCTGCC
  CGCCCCTGAAGCTACTGGCGCCNTGGGGGCTGTCNCCTCAGTATCTNCTCTGTTAGACAN
  AAGTAAGCCCTGTGGTNCTTTGCCAAAAAAAANNNNNNNNNAAAANAAAAAAAANCCCGC
  CCTGGATGCCGCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_144779
• ORF Size: 537 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_144779.1, NP_659003.1
• RefSeq Size: 1631
• RefSeq ORF: 537
• Locus ID: 53827
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
  Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.