BACE2 (NM_138992) Human Untagged Clone

CAT#: SC127678

BACE2 (untagged)-Human beta-site APP-cleaving enzyme 2 (BACE2), transcript variant b

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BACE2
• Synonyms: AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127678 sequence for NM_138992 edited (data generated by NextGen Sequencing)
  ATGGGCGCACTGGCCCGGGCGCTGCTGCTGCCTCTGCTGGCCCAGTGGCTCCTGCGCGCC
  GCCCCGGAGCTGGCCCCCGCGCCCTTCACGCTGCCCCTCCGGGTGGCCGCGGCCACGAAC
  CGCGTAGTTGCGCCCACCCCGGGACCCGGGACCCCTGCCGAGCGCCACGCCGACGGCTTG
  GCGCTCGCCCTGGAGCCTGCCCTGGCGTCCCCCGCGGGCGCCGCCAACTTCTTGGCCATG
  GTAGACAACCTGCAGGGGGACTCTGGCCGCGGCTACTACCTGGAGATGCTGATCGGGACC
  CCCCCGCAGAAGCTACAGATTCTCGTTGACACTGGAAGCAGTAACTTTGCCGTGGCAGGA
  ACCCCGCACTCCTACATAGACACGTACTTTGACACAGAGAGGTCTAGCACATACCGCTCC
  AAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGACGGGCTTCGTTGGGGAA
  GACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCAACATTGCCACTATT
  TTTGAATCAGAGAATTTCTTTTTGCCTGGGATTAAATGGAATGGAATACTTGGCCTAGCT
  TATGCCACACTTGCCAAGCCATCAAGTTCTCTGGAGACCTTCTTCGACTCCCTGGTGACA
  CAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCGGCTTGCCCGTTGCT
  GGATCTGGGACCAACGGAGGTAGTCTTGTCTTGGGTGGAATTGAACCAAGTTTGTATAAA
  GGAGACATCTGGTATACCCCTATTAAGGAAGAGTGGTACTACCAGATAGAAATTCTGAAA
  TTGGAAATTGGAGGCCAAAGCCTTAATCTGGACTGCAGAGAGTATAACGCAGACAAGGCC
  ATCGTGGACAGTGGCACCACGCTGCTGCGCCTGCCCCAGAAGGTGTTTGATGCGGTGGTG
  GAAGCTGTGGCCCGCGCATCTCTGATTCCAGAATTCTCTGATGGTTTCTGGACTGGGTCC
  CAGCTGGCGTGCTGGACGAATTCGGAAACACCTTGGTCTTACTTCCCTAAAATCTCCATC
  TACCTGAGAGAYGAGAACTCCAGCAGGTCATTCCGTATCACAATCCTGCCTCAGAAATTG
  CAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAG
  
  Clone variation with respect to NM_138992.1
  1092 c=>y
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_138992 unedited
  GTAACACGACTTACTATAGGGCGGCCGCGCAATTCGCACGAGGGCCCCGCGCGCCGGCCG
  AGTCGCTGAGCCGCGGCTGCCGGACGGGACGGGACCGGCTAGGCTGGGCGCGCCCCCCGG
  GCCCCGCCGTGGGCATGGGCGCACTGGCCCGGGCGCTGCTGCTGCCTCTGCTGGCCCAGT
  GGCTCCTGCGCGCCGCCCCGGAGCTGGCCCCCGCGCCCTTCACGCTGCCCCTCCGGGTGG
  CCGCGGCCACGAACCGCGTAGTTGCGCCCACCCCGGGACCCGGGACCCCTGCCGAGCGCC
  ACGCCGACGGCTTGGCGCTCGCCCTGGAGCCTGCCCTGGCGTCCCCCGCGGGCGCCGCCA
  ACTTCTTGGCCATGGTAGACAACCTGCAGGGGGACTCTGGCCGCGGCTACTACCTGGAGA
  TGCTGATCGGGACCCCCCCGCAGAAGCTACAGATTCTCGTTGACACTGGAAGCAGTAACT
  TTGCCGTGGCAGGAACCCCGCACTCCTACATAGACACGTACTTTGACACAGAGAGGTCTA
  GCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGACGG
  GCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCA
  ACATTGCCACTATTTTTGAATCAGAGAATTTCTTTNTGCCTGGGATTAAATGGAATGGAA
  TACTTGGCCTAGCTTATGCCACACTTGCCAAGCCATCANAGTCTCTGGAGACCTTCTTCG
  ACTCCCTGGTGACACAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCC
  GCTTGCCCGTTGCTGGATCTGGGACCCACGGNAGTAGTCTGTCTTGGNTGGAANTGAACA
  AGTTGTATAAAGAGACATCTGTATACCCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_138992 unedited
  GGCCGCATTTTAGAGTCGAGTTTTTTTTTTTTTTTTTTCTTGGAAGTAGGGAGGATTTGA
  AAGCTTGAAAATCAAGAATCAAAAGACAGTGAATCTAGAAGGCATCTGGGAGCAGAACAG
  AGATTGAAGACGGGTGGGCACAGGAGAAAGCGCCACCATCGATCCCGGCTGCTGCCCTGG
  AAATGTGATTTTCTTAATAGCTGAGTTCATGGTTGCTTGAGGTCAGGCCTGGCTATTCAT
  TTCCAGCGATGTCTGACCAGAGAGGACTCATCATTGACGACCTCAGGGTCACGGGGGCGA
  CGCTGACACCGGAACGGCAGCAGCAGCAGGACGATTAAGACAAGGAGGATGGCTCCACAG
  ACGCTCATGAGCGCATAGGACACAATCCACAAAATGGGCTCGCTCAAAGACTGAGCGGGG
  ACACAGTTGCTGGCTACATCCTCTGTTGAGAAAGGCCCGGAAATTTCAGACACTGCAGCA
  CCTGCAATTTCTGCACAGGGGCTCGCTGCGAAGCCCACCCTCTTCTGGGCTCTGTCGAAG
  ATGACGTAGAAGCCCTCCATCACCGTGGCACCAATCACCAGCGCATTTGTGGATGGGGAA
  ATGCCGAATCGGTAACATTCATAATTCAGGCCGGCCCCCATCATGGGCTGAATGTAAAGC
  TGAGGCAGGATTGTGATACGGAATGACCTGCTGGAGTTCTCGTCTCTCAGGTAGATGGAG
  ATTCTAGGGAAGTAAGACCAAGGTGTTCCGAATTCGTCCAGCACGCCAGCTGGGACCCAG
  TCCAGAAACCATCAGNAGAATTCTGGGAATCAGAGATGCGCGGNCCCACAGCTTTCACCA
  CCGCATCAAACACCTTCTGGGGCGCAGCCGCACAACGTGGTGGCACTGTCCACNATGCCC
  TGCTTGCGNATACTTTTTGCAGCCAGATTAAGCTTTGGCCTCCATTCCAATTTCAGATTC
  TTATTGTAGACN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_138992
• ORF Size: 1191 bp
• Insert Size: 1920
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_138992.1, NP_620477.1
• RefSeq Size: 2824
• RefSeq ORF: 1191
• Locus ID: 25825
• Domains: asp
• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease
• Gene Summary: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (b) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant a. The encoded isoform (B) is shorter and has a distinct C-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.