MRCL3 (MYL12A) (NM_006471) Human Untagged Clone

CAT#: SC127713

MYL12A (untagged)-Human myosin, light chain 12A, regulatory, non-sarcomeric (MYL12A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MYL12A
• Synonyms: HEL-S-24; MLC-2B; MLCB; MRCL3; MRLC3; MYL2B
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006471, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTCGAGCAAAAGAACAAAGACCAAGACCAAGAAGCGCCCTCAGCGTGCAACATCCAATGTGTTTGCTA
  TGTTTGACCAGTCGCAGATTCAGGAGTTCAAAGAGGCCTTCAACATGATTGATCAGAACAGAGATGGTTT
  CATCGACAAGGAAGATTTGCATGATATGCTTGCTTCATTGGGGAAGAATCCAACTGATGAGTATCTAGAT
  GCCATGATGAATGAGGCTCCAGGCCCCATCAATTTCACCATGTTCCTCACCATGTTTGGTGAGAAGTTAA
  ATGGCACAGATCCTGAAGATGTCATCAGAAATGCCTTTGCTTGCTTTGATGAAGAAGCAACTGGCACCAT
  ACAGGAAGATTACTTGAGAGAGCTGCTGACAACCATGGGGGATCGGTTTACAGATGAGGAAGTGGATGAG
  CTGTACAGAGAAGCACCTATTGATAAAAAGGGGAATTTCAATTACATCGAGTTCACACGCATCCTGAAAC
  ATGGAGCCAAAGACAAAGATGACTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006471 unedited
  GTCAGATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGGTGCTCGGATT
  CTCGTAGCTGTGCCGGGACTTAACCACCACCATGTCGAGCAAAAGAACAAAGACCAAGAC
  CAAGAAGCGCCCTCAGCGTGCAACATCCAATGTGTTTGCTATGTTTGACCAGTCACAGAT
  TCAGGAGTTCAAAGAGGCCTTCAACATGATTGATCAGAACAGAGATGGTTTCATCGACAA
  GGAAGATTTGCATGATATGCTTGCTTCATTGGGGAAGAATCCAACTGATGAGTATCTAGA
  TGCCATGATGAATGAGGCTCCAGGCCCCATCAATTTCACCATGTTCCTCACCATGTTTGG
  TGAGAAGTTAAATGGCACAGATCCTGAAGATGTCATCAGAAATGCCTTTGCTTGCTTTGA
  TGAAGAAGCAACTGGCACCATACAGGAAGATTACTTGAGAGAGCTGCTGACAACCATGGG
  GGATCGGTTTACAGATGAGGAAGTGGATGAGCTGTACAGAGAAGCACCTATTGATAAAAA
  GGGGAATTTCAATTACATCGAGTTCACACGCATCCTGAAACATGGAGCCAAAGACAAAGA
  TGACTGAAATAACTTCAAATTCCAGCCAAACGTTCCTTGTTGCCACTTTGGGTATTCTGA
  GATTNTCTCTTGCATGCCCTTAGCTNTACAGCTTTTGCATTTCCTGTTGTATTTATTCTC
  AGCCATTNTGGGCATATGTATCTTTATAATCAGACTGGAAACGGGACTCTCTATTAATAT
  CATTTTCAGAATNAAAATAGGATAATTTAACCTACCAGCCCTTCTCCNCNCATACTGTGG
  TCTATACAGAGTCATATATCNTTTCAGAGAAAGTNATTCGCTCGATTCCTTCTGAATCAT
  TATTAAACTCTATGATAAAATAAAAAAAAAAAAAAACTCGCTCTAGATGCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006471
• ORF Size: 516 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006471.2, NP_006462.1
• RefSeq Size: 1243
• RefSeq ORF: 516
• Locus ID: 10627
• Domains: EFh
• Protein Pathways: Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Tight junction
• Gene Summary: This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Dec 2014]
  Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2 and 3 encode the same isoform (1).