DPM2 (NM_003863) Human Untagged Clone

CAT#: SC127744

DPM2 (untagged)-Human dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit (DPM2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DPM2
• Synonyms: CDG1U
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127744 sequence for NM_003863 edited (data generated by NextGen Sequencing)
  ATGGCCACGGGGACAGACCAGGTGGTGGGACTCGGCCTCGTCGCCGTTAGCCTGATCATC
  TTCACCTACTACACCGCCTGGGTGATTCTCTTGCCATTCATCGACAGTCAGCATGTCATC
  CACAAGTATTTCCTGCCCCGAGCCTATGCTGTCGCCATCCCACTGGCTGCAGGCCTCCTG
  CTGCTCCTGTTTGTGGGACTGTTCATCTCCTACGTGATGCTGAAGAGCAAGAGAGTGACC
  AAGAAGGCTCAGTGA
  
  Clone variation with respect to NM_003863.3
  213 t=>c;227 c=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003863 unedited
  CGTCCAGAATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCG
  CGGGNGAAATGGCCACGGGGACAGACCAGGTGGTGGGACTCGGCCTCGTCGCCGTTAGCC
  TGATCATCTTCACCTACTACACCGCCTGGGTGATTCTCTTGCCATTCATCGACAGTCAGC
  ATGTCATCCACAAGTATTTCCTGCCCCGAGCCTATGCTGTCGCCATCCCACTGGCTGCAG
  GCCTCCTGCTGCTCCTGTTTGTGGGACTGTTCATCTCCTACGTGATGCTGAAGAGCAAGA
  GAGTGACCAAGAAGGCTCAGTGAAGGTCCCGCAGGGATGAGGCTGCCAGCCCCTTCTCTG
  CTTCCCCTCCAGCACAGGGACCAAGTGGGGGAGCCTGCAGAACCTGTCCAGGCACAGTGG
  CTCCTCAAGCCTGCCTGTCCTGCAGAGTCCCCATGGCATGGAGCTTACACCTGACTGACT
  GGAGCCCCCTCCCCGACTCCCACTTCCAGAAGCTAGGAGGGAGGGATACCTGGAAGACTC
  CGGTCACCTCCTTCTTGCTCANGGCCTAAAAGATGCTGGTCCTCCCAACCTCACTCTCAG
  ACTCCCTGCCACCTTTTCCCCTGNGTTCTGCCGTCTTGCCTCACTTCCCCTCCTGTCACA
  TGCTGACGTTGGACTTAGCANGTTCTAAGGCCACATGTGTGACCTCTCTGACTTCTCTTC
  CTNCCCAAAGCAGCTTTCCTTACCCTGAACAGCCCCAGACCCACAAAGCCTTCTGACCCT
  GAAAGCTGGGGAAGACTGACAGACCCCAGAACAGCCCTGGGCTCAAGCAGCCACCCCGGC
  CGCTGACGACTGGACTCTCTCACGGAGCCCAGCCCAAACCCCAAGCTGGCCCGTGGGGAC
  ACTAACCATAAACCGATGTGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003863
• ORF Size: 255 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003863.1, NP_003854.1
• RefSeq Size: 291
• RefSeq ORF: 255
• Locus ID: 8818
• Protein Families: Transmembrane
• Protein Pathways: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, N-Glycan biosynthesis
• Gene Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the longer isoform (1).