CBR4 (NM_032783) Human Untagged Clone

CAT#: SC127775

CBR4 (untagged)-Human carbonyl reductase 4 (CBR4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBR4
• Synonyms: SDR45C1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127775 sequence for NM_032783 edited (data generated by NextGen Sequencing)
  ATGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAG
  TTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAGAAACCTGGAAGGGGCCAAA
  GCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAA
  CATGATGTTCAAAATACATTTGAAGAGATGGAGAAACATTTAGGTCGAGTAAATTTCTTG
  GTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAGAACAAAAACTGAAGATATG
  GTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGG
  ACTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAA
  GGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGGATTAGTTGGATTTTCACGT
  GCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGATTT
  GTACACACAGATATGACGAAAGACTTGAAAGAAGAACATTTAAAGAAAAATATTCCTCTT
  GGGAGGTTTGGAGAAACTATTGAGGTGGCACATGCGGTTGTGTTTCTTTTAGAATCACCG
  TATATTACAGGGCATGTTCTGGTAGTGGATGGGGGATTACAACTCATTTTGTAA
  
  Clone variation with respect to NM_032783.4
  208 c=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_032783 unedited
  TACTATAGGGCGGCCGCGAATTCGGCACGAGGGAGGTGTCGAGCGGCGTTATTTTTTTTT
  GCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTGGAACCGCGGTTGTTTAAAAGCCTGAG
  GGAACCTGGAGGGGGGCTCCCACTCTCTACCTTCTTTCCTCCGAGTTTGTGACTCCGAGA
  TGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGT
  TAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAGAAACCTGGAAGGGGCCAAAG
  CCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAAC
  ATGATGTTCAAAATACATTTGAAGAGATGGAGAAACATTTAGGTCGAGTAAATTTCTTGG
  TAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAGAACAAAAACTGAAGATATGG
  TATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGA
  CTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTANGAAGCATTGNTGGCTTAAAAG
  GCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGGATTAGTTGGATTTTTCACGT
  GCTCTTGCTAAAGAGGGTAGCAGAAAGAAAATAGAGTGAATGTAGTTGCACCCAGTGACA
  TACTTGTATGGGGAGTTATTTTGCACATTTGCAAGTATATGAAGTGTAATCTTGGGACTG
  GAACTGCNAANNGCTCANAGGATTTGTCACACAGATATGACGAAAGACTTGAAAGAGAAC
  ATTTAAGAAAAATATTCTCTTGGGAGGNTNGAGAAACTATGAGTGGCCATGCGGGTGTGT
  TCTTTAAATCACTTATACAGGCATGTNCTGGATGAATGGGGATACACTCATTGTATTGCG
  ATATCAGTTTAGGGGGATACATCAGGCACTTTGCTACTGTA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_032783 unedited
  ATGGACCGCGGCCGCACTCNAGATCGAGTTTTTTTCTTTTTTTTTTAAAATCATTAAATA
  CTTTATTTAAGAACAGTTTGTTTACCAAGTTAGGACAGTGGTTATGATTTCTCAATTTAC
  ACATATTCCTTTTGAAAATCTTAGAAAAAATGTTTCACCAATGTTAAGGTACAACTCTTG
  AATATGCAGCGTAGTCTTCTCTCTTTATTCTGAATAACAGAAGCACGTAAATTAAATTAT
  CCTCTTTGCACAATTATTCCCCCCAAAACTAATTTATAACATATAATTATCTCCCTAAAA
  AGCAGTTACAAACCATAAATTGAATATGAATAAAATATGAAAAAGAGCACAAATTTTAAA
  GCCCTCCATGCAAAAAAAAATTAATACATTGGCTTTACCTATAAACCTTATTTTGTTAAT
  GCTAAGCACAGAACCCTTATGGGCTCATAGGAGTCAGCAAACAGCTACAGATGAGTCTTC
  TTGTTAAGAATTCATTCAATGCTTCTCAGAATAGCAGATTTTAAAAAATGAATTCACTGA
  GGTTCTTAAACCTCTGAACATAAGGCAACAGTTCACAACTGATTTCAGAAATAGAAGGTA
  AGTATTAAATTACAAATTCTACTAGGTCAGTGGGAGTGGGCGGATTCACCTGGAGTGGAG
  CAGTGAAGGTTTATTTTACCTCTTTCAAGATCTCTCCATATATTCCACCAGTTTGAGATA
  GGCTGGGGGAGGAGGTGGAATAGCTTAAAGGTTATATTTCTTATTTTAAGTATAAAACAT
  ACACTTAAGGCTNAACTATCTATACCTACATCTAATGTCAGCAAACATACTGCTTTCTAC
  CCAATCACCAANTGATCAGCCTCGCTCATGATTTCGAGCATAAGGTGTCCGAGAAAAAAC
  TCNAGATGNATGGGCTGCCATATGGGGAAGTACAGTAGCCAAGGCCACATTGAGACAGCT
  ANAGAACTTCTACTTGNCTGAATAGCCN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_032783
• ORF Size: 714 bp
• Insert Size: 3270
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_032783.3, NP_116172.2
• RefSeq Size: 3474
• RefSeq ORF: 714
• Locus ID: 84869
• Domains: adh_short
• Protein Families: Druggable Genome
• Gene Summary: The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). [UniProtKB/Swiss-Prot Function]