MMP8 (NM_002424) Human Untagged Clone

CAT#: SC127843

MMP8 (untagged)-Human matrix metallopeptidase 8 (neutrophil collagenase) (MMP8)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MMP8
• Synonyms: CLG1; HNC; MMP-8; PMNL-CL
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127843 sequence for NM_002424 edited (data generated by NextGen Sequencing)
  ATGTTCTCCCTGAAGACGCTTCCATTTCTGCTCTTACTCCATGTGCAGATTTCCAAGGCC
  TTTCCTGTATCTTCTAAAGAGAAAAATACAAAAACTGTTCAGGACTACCTGGAAAAGTTC
  TACCAATTACCAAGCAACCAGTATCAGTCTACAAGGAAGAATGGCACTAATGTGATCGTT
  GAAAAGCTTAAAGAAATGCAGCGATTTTTTGGGTTGAATGTGACGGGGAAGCCAAATGAG
  GAAACTCTGGACATGATGAAAAAGCCTCGCTGTGGAGTGCCTGACAGTGGTGGTTTTATG
  TTAACCCCAGGAAACCCCAAGTGGGAACGCACTAACTTGACCTACAGGATTCGAAACTAT
  ACCCCACAGCTGTCAGAGGCTGAGGTAGAAAGAGCTATCAAGGATGCCTTTGAACTCTGG
  AGTGTTGCATCACCTCTCATCTTCACCAGGATCTCACAGGGAGAGGCAGATATCAACATT
  GCTTTTTACCAAAGAGATCACGGTGACAATTCTCCATTTGATGGACCCAATGGAATCCTT
  GCTCATGCCTTTCAGCCAGGCCAAGGTATTGGAGGAGATGCTCATTTTGATGCCGAAGAA
  ACATGGACCAACACCTCCGCAAATTACAACTTGTTTCTTGTTGCTGCTCATGAATTTGGC
  CATTCTTTGGGGCTCGCTCACTCCTCTGACCCTGGTGCCTTGATGTATCCCAACTATGCT
  TTCAGGGAAACCAGCAACTACTCACTCCCTCAAGATGACATCGATGGCATTCAGGCCATC
  TATGGACTTTCAAGCAACCCTATCCAACCTACTGGACCAAGCACACCCAAACCCTGTGAC
  CCCAGTTTGACATTTGATGCTATCACCACACTTCGTGGAGAAATACTTTTCTTTAAAGAC
  AGGTACTTCTGGAGAAGGCATCCTCAGCTACAAAGAGTCGAAATGAATTTTATTTCTCTA
  TTCTGGCCATCCCTTCCAACTGGTATACAGGCTGCTTATGAAGATTTTGACAGAGACCTC
  ATTTTCCTATTTAAAGGCAACCAATACTGGGCTCTGAGTGGCTATGATATTCTGCAAGGT
  TATCCCAAGGATATATCAAACTATGGCTTCCCCAGCAGCGTCCAAGCAATTGACGCAGCT
  GTTTTCTACAGAAGTAAAACATACTTCTTTGTAAATGACCAATTCTGGAGATATGATAAC
  CAAAGACAATTCATGGAGCCAGGTTATCCCAAAAGCATATCAGGTGCCTTTCCAGGAATA
  GAGAGTAAAGTTGATGCAGTTTTCCAGCAAGAACATTTCTTCCATGTCTTCAGTGGACCA
  AGATATTACGCATTTGATCTTATTGCTCAGAGAGTTACCAGAGTTGCAAGAGGCAATAAA
  TGGCTTAACTGTAGATATGGCTGA
  
  Clone variation with respect to NM_002424.2
  873 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002424 unedited
  CCCCCAGGCGANACCCCNNCCCCCCCCCCCCCCCGTTCGACATTTGTNATACGACTCACT
  ATAGGGCGGCNCGCGATTCGGCACGAGNAACCTCAGGGTGCTCGCCAGGGAAGGGCCCTA
  CCCAGAGGGACAGAAAGAAAGCCAGGAGGGGTAGAGTTTGAAGAGAAGATCATGTTCTCC
  CTGAAGACGCTTCCATTTCTGCTCTTACTCCATGTGCAGATTTCCAAGGCCTTTCCTGTA
  TCTTCTAAAGAGAAAAATACAAAAACTGTTCAGGACTACCTGGAAAAGTTCTACCAATTA
  CCAAGCAACCAGTATCAGTCTACAAGGAAGAATGGCACTAATGTGATCGTTGAAAAGCTT
  AAAGAAATGCAGCGATTTTTTGGGTTGAATGTGACGGGGAAGCCAAATGAGGAAACTCTG
  GACATGATGAAAAAGCCTCGCTGTGGAGTGCCTGACAGTGGTGGTTTTATGTTAACCCCA
  GGAAACCCCAAGTGGGAACGCACTAACTTGACCTACAGGATTCGAAACTATACCCCACAG
  CTGTCAGAGGCTGAGGTAGAAAGAGCTATCAAGGATGCCTTTGAACTCTGGAGTGTTGCA
  TCACCTCTCATCTTCACCAGGATCTCACAGGGAGAGGCAGATATCAACATTGCTTTTTAC
  CAAAGAGATCACGGTGACAATTCTCCATTTGATGGACCCAATGGAATCCTTGCTCATGCC
  TTTCAGCCCAGCCAAGGTATTGGAGGAGATGCTCATTTTGATGCCCAAGAACATGGACCA
  ACACCTCCGCAAATACAACTTGGTTCTTGGTGCTGCTCATGAAATTGGGCCATTCTTTGG
  GGCTTGTTCACTCCTTTGACCCTGGTGCCTTGATGTATCCCCNCTATGGCTTTAGGGAAA
  ACCACAACTACCCCTCCCTAAGAAGAACTCGATGGCTTTAGGCCCTCTATGGACTTTCAA
  CCACCCCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002424 unedited
  GGTCCAGGAACAGCACTGGGGCAGGGTACCAGGGTATGCCACCCGGGTATCTGGTTCAGG
  TAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATTT
  GAAGTAAAAATCTTTAATTTGAACTTATTTAATAGATTATTTTAATTTTTGAACAAGCAT
  AAGGGTGCCAATTTAATTATCTGTGGGATTTAAAAACTTCAACAGAGAAAGAAAATAGGA
  GGTACTAGTGAGAAATATATTTCACAGTCTACATATTTATTGTATCCTAAGCTATATTAT
  ATTCTAATAACACCAAATATAACCTTATAATGATCTTGATATCTGGACTCGCTAGCCTAG
  GTCCAATAAATCCTATAGTTCTCACCACCGAAACCCATCCGTTAGCAAAATNACGCTTGT
  AAGCTGAGTTTAATGCAACTTAATGAGACATTGAATTTTATGCACCTAACCCAAATTCTC
  TATCGCCCGTGCCCCCCTGAGCCCCCCAGGAAATAGAAGTCAAAAACTGACCTCCCCTCC
  GCTCCAACTGGTCCTCTTCGGTTCGGGACTCTCGGCCACTAAAAGGATGACGCCCGATAG
  GAAATGGTGTTTTTCTTCTGACCGCTGCCCTCGCGAACTGTCTCTTTTATTTCCGCGAGA
  AAGGGATGACACTACAGCCCTCTAGAGACGTCTCATATAATATGCCGCCGCGGAAAAGCC
  CCCCCGCTCATAATGTTCTAGGGTGTTTGACAAATTTTCTTCTCTCTTTGGGGCTAAAGC
  CTCTCCATAAAAACACCCTCTCCCCGCCCCCGAATACCCCCGCAATTACTACTATAAAGA
  GAACCGCCGGGATAAAATTCTGCATTGCTTTCTCTGGGGCTTTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002424
• ORF Size: 1404 bp
• Insert Size: 3050
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_002424.1, NP_002415.1
• RefSeq Size: 2223
• RefSeq ORF: 1404
• Locus ID: 4317
• Domains: hemopexin, Peptidase_M10, ZnMc
• Protein Families: Druggable Genome, Protease
• Gene Summary: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
  Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.