ABCB7 (NM_004299) Human Untagged Clone

CAT#: SC127973

ABCB7 (untagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 7 (ABCB7), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ABCB7
• Synonyms: ABC7; ASAT; Atm1p; EST140535
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004299 edited
  ATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAG
  CGCCGGCACTCCGCGATTCTGATCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAG
  TGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGCAGATTCCAGAG
  TCATTAAAAAGTATCACATGGCAGAGATTGGGAAAAGGCAATTCAGGACAGTTCTTAGAT
  GCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGGTCAT
  GCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAA
  ATCATAAAAGCAATGCTTTCTTATGTGTGGCCCAAAGACAGGCCAGATCTACGAGCTAGA
  GTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGTTCCCTTC
  ATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGT
  GATGCACCAAATACAGTTGCAACCATGGCAACAGCAGTTCTGATTGGCTATGGTGTATCA
  AGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGCCCAG
  AATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGT
  TTTCACCTGAGCAGACAGACGGGAGCTTTATCTAAGGCTATTGACAGAGGAACAAGGGGT
  ATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGTGATG
  CTTGTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGA
  ACACTTGGTACATACACAGCATTCACAGTTGCAGTCACACGGTGGAGAACTAGATTTAGA
  ATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCTGAAT
  TATGAAACTGTGAAGTATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTT
  TTGAAGACGTATGAGACTGCTTCATTGAAAAGTACCTCTACTCTGGCTATGCTGAACTTT
  GGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCAGGGA
  ATTGTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAG
  CTTTCATTACCCCTGAACTTTCTGGGAACTGTATATAGAGAGACTAGACAAGCACTCATA
  GATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGTGATG
  GCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTT
  GAATACATTGAGGGCCAGAAAGTCCTTAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAG
  AAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATTATTT
  CGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTG
  AGCCTGGAAAGCCTTCGGAGGGCAGTGGGAGTGGTACCTCAGGATGCTGTCCTCTTCCAT
  AATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGTGTAT
  GCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGAC
  ACCCAAGTAGGGGAACGAGGACTCAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATT
  GCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATCGTTA
  GATTCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACT
  TCTATTTTCATTGCACACAGATTGTCAACAGTGGTTGATGCAGATGAAATCATTGTCTTG
  GATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCATAGT
  ATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAA
  TGGGAAGCAAAGAAAGAAAATATATCCAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAA
  ATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_004299
• ORF Size: 2262 bp
• Insert Size: 2300
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004299.3, NP_004290.2
• RefSeq Size: 2404
• RefSeq ORF: 2262
• Locus ID: 22
• Domains: ABC_membrane, ABC_tran, AAA
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.