Dishevelled 2 (DVL2) (NM_004422) Human Untagged Clone

CAT#: SC128046

DVL2 (untagged)-Human dishevelled, dsh homolog 2 (Drosophila) (DVL2)


  "NM_004422" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol DVL2
Synonyms dishevelled, dsh homolog 2 (Drosophila); dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); DSH homolog 2; segment polarity protein dishevelled homolog DVL-2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC128046 sequence for NM_004422 edited (data generated by NextGen Sequencing)
ATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTGGGGAGACGAAGGTGATTTACCACCTG
GATGAGGAAGAGACTCCCTACCTGGTGAAGATCCCTGTCCCCGCCGAGCGCATCACCCTC
GGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTTTTTCAAGTCTATG
GATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAGATGACAACGCCCGCCTCCCCTGC
TTCAACGGAAGGGTGGTATCCTGGCTGGTGTCCTCAGATAATCCCCAACCCGAGATGGCC
CCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACCTTTACCTCCTTTG
CCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGCCTCCATCCTTCCACCCTAATGTG
TCCAGCAGCCATGAGAATCTGGAGCCTGAGACAGAAACCGAGTCAGTAGTGTCACTGAGG
CGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATGGCGCTGGGGGCCACAGGACTGGT
GGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACGAGAGCTCCTCTACCCTCATGACC
AGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACGAGGAGGACACCATGAGCAGGTTC
AGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTTAAGCGCCACCGGCGGCGAAGG
AAGCAGAGGCCACCCCGCCTGGAGAGGACGTCATCCTTCAGCAGCGTCACAGATTCCACA
ATGTCTCTCAATATCATCACAGTCACGCTAAACATGGAGAAGTACAACTTCCTGGGTATC
TCCATTGTTGGCCAGAGCAATGAGCGGGGAGACGGAGGCATCTACATTGGCTCCATCATG
AAGGGTGGGGCTGTGGCGGCCGACGGGCGCATTGAGCCAGGGGACATGCTTTTGCAGGTG
AATGACATGAACTTTGAGAACATGAGCAACGATGACGCTGTGCGGGTGCTGAGGGACATT
GTGCACAAGCCTGGCCCCATTGTGCTGACTGTGGCCAAGTGCTGGGATCCCTCTCCTCAG
GCCTATTTCACTCTCCCCCGAAATGAGCCCATCCAGCCAATTGACCCTGCTGCCTGGGTG
TCCCATTCCGCGGCTCTGACTGGCACCTTCCCAGCCTATCCAGGTTCCTCCTCCATGAGC
ACCATTACATCTGGATCGTCTTTGCCTGATGGCTGTGAAGGCCGGGGTCTCTCCGTCCAT
ACGGACATGGCATCGGTGACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGGAAGTCCGG
GACCGCATGTGGCTCAAGATCACCATCCCTAATGCCTTTCTGGGCTCGGATGTGGTTGAC
TGGCTCTACCATCACGTGGAGGGCTTTCCTGAGCGGCGGGAGGCCCGCAAGTATGCCAGC
GGGCTGCTCAAAGCAGGCCTGATCCGACACACCGTCAACAAGATCACCTTCTCTGAGCAG
TGCTATTACGTCTTCGGAGACCTCAGTGGTGGCTGTGAGAGCTACCTAGTCAACCTGTCT
CTCAATGACAACGATGGCTCCAGTGGGGCTTCAGACCAGGATACCCTGGCTCCTCTGCCT
GGGGCCACCCCCTGGCCCCTGCTGCCCACTTTCTCCTACCAATACCCTGCCCCACACCCC
TACAGCCCGCAGCCTCCACCCTACCATGAGCTTTCATCTTACACCTATGGTGGGGGCAGT
GCCAGCAGCCAGCATAGTGAGGGCAGCCGGAGCAGTGGGTCGACACGGAGTGATGGGGGG
GCAGGGCGCACGGGGAGGCCCGAGGAGCGGGCCCCCGAGTCCAAGTCCGGCAGTGGCAGT
GAGTCTGAGCCCTCCAGCCGAGGGGGCAGCCTTCGGCGGGGTGGGGAAGCAAGTGGGACT
AGCGATGGGGGCCCTCCTCCATCCAGAGGCTCAACTGGGGGTGCCCCTAATCTCCGAGCC
CACCCAGGGCTCCATCCCTATGGACCGCCCCCTGGCATGGCCCTCCCCTACAACCCCATG
ATGGTGGTCATGATGCCCCCACCTCCACCTCCAGTCCCTCCAGCAGTGCAGCCTCCGGGG
GCCCCTCCAGTCAGAGACCTGGGCTCTGTGCCCCCAGAACTGACAGCCAGCCGCCAAAGC
TTCCACATGGCCATGGGCAATCCCAGCGAGTTCTTTGTGGATGTTATGTAG

Clone variation with respect to NM_004422.2
>OriGene 5' read for NM_004422 unedited
GCCACAGGAGCTACACGAATACCACAGGGCGGCCGCGAAACGGCACGAGGGGGCGGCGGA
GCCCGGGAGCGCGCGGGCGAGACACGGCGGGAAGCAGCACCGGGGGCGGCGGGGACGGGG
AGACGAAGGCGATCTACCACCTGGATGAGGAAGAGACTCCCTACCTGGTGAAGACCCCTG
TCCCCGCCGAGCGCATCACCCTCGGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCG
CCAAGTACTTTTTCAAGTCTATGGATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAG
ATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGTATCCTGGCTGGTGTCCTCAG
ATAATCCCCAACCCGAGATGGCCCCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTC
CAGCCCCACCTTTACCTCCTTTGCCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGC
CTCCATCCTTCCACCCTAATGTGTCCAGCAGCCATGAGAATCTGGAGCCTGAGACAGAAA
CCGAGTCAGTAGTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATG
GCGCTGGGGGCCACAGGACTGGTGGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACG
AGAGCTCCTCTACCCTCATGACCAGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACG
AGAGGACACCATGAGCAGTTCAGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTT
AAGCGCCACCGGCGGCGAAGAAGCAGAGGCCACCCCCGCCTGAGAGGACGTCATCCTTCA
GCAGCGTCACAGATTCCACAATGTCTCTCATATCATCACAGTCACGCTAAACATGGAGAA
GTACACTTCCTGGGTATCTCCATTGTTGGCCAGAGCAATGAGCGGGGGAGACGAAGCATC
TACA
>Forward primer walk for NM_004422 unedited
GGGGCCCCTTCCATCCATCCTCCTCATGCAGCCTCCGGGGCCCCTCCATCAGAGACCTGG
GCTCTGTGCCCCCANAACTGACAGCCAGCCGCCAAAGCTTCCACATGGCCATGGGCAATC
CCAGCGAGTTCTTTGTGGATGTTATGTAGCCCACTGTGGGGCCAGGCTGGGCCGGGCGCT
CCTGGTGTGTGACTGGGTGTCCTGGCCGTCATGTGCTTGCTCTTACAGTGCCTGGGCTCA
GCCTACCAGCTGCTGCCATACAGGAGATTGTGGCCACTGTGACTCTCACCAGCAGTGCCT
GGTTCCTCCCCCTTCCCTCAGGGGTAGACAAGGGACCTTTGATTATTTTTAGCTTTGTTT
TTTTATAAGCCTTTTTGGGGGTTAAAATAGAGTTTCTTACATTTTTGGGACTTTTTTAAT
AGGCATTTCCTCTTTTATATGAAGAATTCCCATCCATTGGGCCCCTTCTAACCCCAGAAT
GTGACCTCCTCCTCCAGTTACCCACAGCCCTGCCCTTTGCAGGGTTGGGGGTGGTCAGCG
GTACCCCGGGGTTAGGCATCCTAGACAGCAGCCTGAGGAAGCTGGGAGATTTGGGCCATG
TAGCTGCCTTTGTTACTCTATTTATTTTAGTCACTTGTATAAAACACCAAATAAAGCAAT
AGAGGCAAACTCAAAANANAAAAANGACAAGAAGGAAGGTGCGGAGGGCAAACCTGCGCC
ACACACAAAAAATCCAACACAAGAAAGACCCAAAGAAAANAAGAAGCGAGACAACCCCAC
CTAAATAAAGAAAACTTCTTTTTTGTTTGGGGGCCGGGACAATTATTTTTTCCAAAAAAA
ATCCGG
Restriction Sites NotI-NotI     
ACCN NM_004422
Insert Size 3050 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004422.2, NP_004413.1
RefSeq Size 3046 bp
RefSeq ORF 2211 bp
Locus ID 1856
Cytogenetics 17p13.1
Domains DEP, DAX, PDZ, Dishevelled
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway
Gene Summary 'This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]'

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