ACK1 (TNK2) (NM_005781) Human Untagged Clone

CAT#: SC128079

TNK2 (untagged)-Human tyrosine kinase, non-receptor, 2 (TNK2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNK2
• Synonyms: ACK; ACK-1; ACK1; p21cdc42Hs
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005781 edited
  CCGGGATCGCGGAGCCGGCTGAGCGCAGGGCCGAGCTGCGGGGCAGAGGCTGGGAGGCGG
  CAGAATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTGGAGCTGCTGTCCGAGGTGCAGCT
  GCAACAGTACTTCCTGCGGCTCCGAGACGACCTCAACGTCACCCGCCTGTCCCACTTTGA
  GTACGTCAAGAATGAGGACCTGGAGAAGATCGGCATGGGTCGGCCTGGCCAGCGGCGGCT
  GTGGGAGGCTGTGAAGAGGAGGAAGGCCTTGTGCAAACGCAAGTCGTGGATGAGTAAGGT
  GTTCAGTGGAAAGCGACTGGAGGCTGAGTTCCCACCTCATCACTCTCAGAGCACCTTCCG
  GAAGACCTCGCCCGCCCCTGGGGGCCCAGCAGGGGAGGGGCCCCTGCAGAGCCTCACCTG
  CCTCATTGGGGAGAAGGACCTGCGCCTCCTGGAGAAGCTGGGTGATGGTTCCTTTGGCGT
  GGTGCGCAGGGGCGAGTGGGACGCGCCCTCAGGGAAGACGGTGAGTGTGGCTGTGAAGTG
  CCTGAAGCCCGATGTCCTGAGCCAGCCAGAAGCCATGGACGACTTCATCCGGGAGGTCAA
  TGCCATGCACTCGCTCGACCACCGAAACCTCATCCGCCTCTACGGGGTGGTGCTCACGCC
  GCCCATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCGTTGTTGGACCGGCTACGTAA
  GCACCAGGGCCACTTCCTCCTGGGGACTCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGG
  CATGGGCTACCTGGAGTCCAAGCGCTTTATTCACCGTGACCTGGCTGCCCGCAATCTGCT
  GTTGGCTACCCGCGACCTGGTCAAGATCGGGGACTTTGGGCTGATGCGAGCACTACCTCA
  GAATGACGACCATTACGTCATGCAGGAACATCGCAAGGTGCCCTTCGCCTGGTGTGCCCC
  CGAGAGCCTGAAGACACGTACCTTCTCCCATGCCAGCGACACCTGGATGTTCGGGGTGAC
  ACTGTGGGAAATGTTCACCTACGGCCAGGAGCCCTGGATCGGCCTCAACGGCAGTCAGAT
  CCTGCATAAGATCGACAAGGAGGGGGAGCGGCTGCCCCGGCCCGAGGACTGTCCCCAGGA
  CATCTACAACGTCATGGTCCAGTGCTGGGCTCACAAGCCAGAGGACAGACCCACGTTTGT
  GGCCCTGCGGGACTTCCTGCTGGAGGCCCAGCCCACAGACATGCGGGCCCTTCAGGACTT
  TGAGGAACCGGACAAGCTGCACATCCAGATGAATGATGTCATCACCGTCATCGAGGGAAG
  GGCCGAGAACTACTGGTGGCGTGGCCAGAACACACGGACGCTGTGTGTGGGGCCCTTCCC
  TCGCAACGTGGTGACCTCCGTGGCCGGCCTGTCGGCCCAGGACATCAGCCAGCCCCTGCA
  GAACAGCTTCATCCACACAGGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCC
  GGACAGGATTGACGAACTGTATCTGGGAAACCCCATGGACCCCCCCGACCTCCTGAGCGT
  GGAACTGAGCACCTCCCGGCCCCCCCAGCATCTAGGAGGGGTGAAAAAACCAACCTATGA
  CCCTGTGAGCGAGGACCAAGACCCCTTGTCCAGCGACTTCAAGAGGCTGGGCCTGCGGAA
  GCCAGGCCTGCCCCGAGGGCTGTGGCTGGCGAAGCCCTCGGCGCGGGTGCCGGGCACCAA
  GGCCAGCCGAGGCAGCGGGGCTGAGGTCACGCTCATCGACTTCGGTGAGGAGCCCGTGGT
  CCCGGCCCTACGGCCCTGCGCGCCCTCCCTGGCGCAGCTGGCCATGGACGCCTGCTCCCT
  GCTGGACGAGACCCCGCCTCAGAGCCCCACGCGGGCACTGCCCCGGCCCCTGCACCCCAC
  GCCTGTGGTGGACTGGGACGCACGCCCGCTGCCCCCCCCGCCCGCCTATGACGACGTGGC
  CCAGGATGAGGATGACTTTGAGATCTGCTCCATCAACAGCACCCTCGTGGGCGCGGGGGT
  CCCTGCCGGGCCCAGCCAGGGCCAGACCAACTACGCCTTTGTGCCTGAGCAGGCGCGGCC
  GCCCCCTCCCCTGGAGGACAACCTGTTCCTCCCGCCCCAGGGTGGGGGCAAGCCGCCCAG
  CTCCGCACAGACCGCAGAGATCTTCCAGGCGCTACAGCAGGAGTGCATGAGGCAACTGCA
  GGCTCCGGCCGGCTCCCCGGCCCCCTCTCCCAGCCCGGGGGGTGACGACAAGCCCCAGGT
  GCCTCCTCGGGTACCCATCCCCCCTCGGCCCACGCGCCCACACGTCCAGCTGTCTCCAGC
  CCCCCCGGGCGAGGAGGAGACCAGCCAGTGGCCTGGACCTGCTTCCCCTCCCCGGGTGCC
  TCCGCGGGAGCCCCTGTCCCCTCAAGGCTCGAGGACACCCAGCCCCCTGGTACCACCTGG
  CAGCTCCCCGCTGCCACCCCGGCTCTCAAGCTCACCTGGGAAGACCATGCCCACCACCCA
  GAGCTTTGCCTCAGACCCCAAGTACGCCACCCCCCAGGTGATCCAGGCCCCTGGCCCGCG
  GGCTGGTCCCTGCATCCTGCCCATCGTCCGGGATGGCAAGAAGGTCAGCAGCACCCACTA
  TTACTTGCTGCCCGAGCGACCATCCTACCTGGAGCGCTACCAGCGCTTCCTGCGTGAGGC
  CCAGAGCCCCGAGGAGCCTACCCCCCTGCCTGTGCCTCTGCTGCTGCCCCCACCCAGCAC
  CCCAGCCCCCGCCGCCCCCACGGCCACCGTGCGGCCGATGCCCCAGGCTGCCTTGGACCC
  CAAGGCCAACTTCTCCACCAACAACAGCAACCCAGGGGCCCGGCCACCACCCCCGAGGGC
  CACTGCTCGGCTGCCACAGAGGGGCTGCCCTGGCGATGGGCCAGAGGCGGGCCGGCCAGC
  AGACAAGATCCAGATGCTGCAGGCCATGGTGCATGGGGTGACCACAGAGGAGTGCCAGGC
  GGCCCTGCAGTGCCACGGCTGGAGCGTGCAGAGGGCTGCCCAGTATCTGAAGGTGGAGCA
  GCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTGGAGATGTTCGA
  CTGGAACCTGGAGCAGGCCGGCTGCCACCTTCTGGGCTCCTGGGGCCCTGCCCACCACAA
  GCGCTGAGATGCGTCTGGAGAGCCAGAGGGCCTGCCTGAAGGAATCACCTGAGCCTGTCC
  GTCCACCAGGAGTGGGGAGATGCCCCCATCCAGTCCTGGAGGACCCGCTGCTCCTGCTGC
  TCCCGGGGATGGAGCAAGGCCAAGGCTGCGGGAGGCTGGGAGCCCTGCCCTGCCCATCCC
  TCCTGCACCAGCGCTGTCCCTGCACACTTTGGTTCAGTCCCGGTGCCCCTGCCAAGATGT
  GGAAGGGGCCGGGTGAAGACAGGCTTGAGGGCTGCCCCAGCAGGCTCTGGGTATGACCTG
  CCTCTGGCCCTGGTCCTGGGCGGGGCCTGTGGGTGGAGTAGTACCCCCAGGCCCTGCCCT
  GGGTGACAGACTGGGAGGAAACCAGGCTGGACCTGGGCAGGCGGGATGTGTTGGCCACAG
  GGAGAGGCGGACCGGCACCCGGTGGGACCTCCTAGGACTGGGCCTTCTTCCAGGGGGCCC
  CTGGCAGCAGCTGGGGTGTCGGGCAGAATGTGACTTGTGGCCTTACCATGGACTTGAATG
  GGACTTGGCTGGCCTCAGGATCTTGTGCCTGGAAATAGCCTGAGGTGGCTCAGGAAGCGG
  AGAAAGGGTGCCAGACCATTCTCTGGCGGGGACCAGGGCCCAAGGCCCCAGGGCTGGAAG
  GAGACCAAGGGGCAGCCGCCCTGGAGGGACATCAGTGCTTCCTCTTCCACCCAATTCCCC
  CACGCGGTTCCATGTTTTCCCACCAGCCTGTTGGCGAAGTTGCTGCTCCGGCATTCAGTA
  CCTGCTTCTTCCAGAGAAATAAAGTTAGTTTCTATTTTATGTTAAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_005781
• ORF Size: 3117 bp
• Insert Size: 4100
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The insert of this clone has been fully sequenced and found to be a perfect match to NM_005781.4 except for 6bp insertion in this clone.

Reference Data

• RefSeq: NM_005781.4, NP_005772.3
• RefSeq Size: 4476
• RefSeq ORF: 3117
• Locus ID: 10188
• Domains: UBA, pkinase, TyrKc, SH3, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.