E2F5 (NM_001951) Human Untagged Clone

CAT#: SC128153

E2F5 (untagged)-Human E2F transcription factor 5, p130-binding (E2F5), transcript variant 1


  "NM_001951" in other vectors (4)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol E2F5
Synonyms E2F-5
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC128153 sequence for NM_001951 edited (data generated by NextGen Sequencing)
ATGGCGGCGGCANNNCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGGGCAGGGC
CAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAG
CTCGGGGGCGCGGGGGGCGGCAGCAGCAGGCACGAGAAGAGCCTGGGGCTGCTCACTACC
AAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGCGGCTGCT
GATACTTTGGCTGTGAGGCAAAAAAGGAGAATTTATGATATCACCAATGTCTTAGAGGGA
ATTGACTTGATTGAAAAAAAGTCAAAAAACAGTATCCAGTGGAAAGGTGTAGGTGCTGGC
TGTAATACTAAAGAAGTCATAGATAGATTAAGATATCTTAAAGCTGAAATTGAAGATCTA
GAACTGAAGGAAAGAGAACTTGATCAGCAGAAGTTGTGGCTACAGCAAAGCATCAAAAAT
GTGATGGACGATTCCATTAATAATAGATTTTCCTATGTAACTCATGAAGACATCTGTAAT
TGCTTTAATGGTGATACACTTTTGGCCATTCAGGCACCTTCTGGTACACAACTGGAGGTA
CCCATTCCAGAAATGGGTCAGAATGGACAAAAGAAATACCAGATCAATCTAAAGAGTCAT
TCAGGACCTATCCATGTGCTGCTTATAAATAAAGAGTCGAGTTCATCTAAGCCCGTGGTT
TTTCCTGTTCCCCCACCTGATGACCTCACACAGCCTTCCTCCCAGTCCTTGACTCCAGTG
ACTCCACAGAAATCCAGCATGGCAACTCAAAATCTGCCTGAGCAACATGTCTCTGAAAGA
AGCCAGGCTCTGCAGCAGACATCAGCTACAGATATATCTTCAGCAGGATCTATTAGTGGA
GATATCATTGATGAGTTAATGTCTTCTGACGTGTTTCCTCTCTTAAGGCTTTCTCCTACC
CCGGCAGATGACTACAACTTTAATTTAGATGATAACGAAGGAGTTTGTGATCTGTTTGAT
GTCCAGATACTAAATTATTAG

Clone variation with respect to NM_001951.3
13 g=>n;14 a=>n;15 g=>n;132 c=>g
>OriGene 5' read for NM_001951 unedited
TTCGGAATTTGTAATACGACTCTACTATAGGGCGGCCGCGAATCGGCACCAGGAAGCGGC
CGCAGTGGAGCCGACCCGGCAGGTGGCCGCGGGCGGGGCCGGCGAGCGAAAGTGCGCGGG
GGCCCGACCACCGCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCA
GCAGGCGCCGGCAGGGCAGGGGCAGGGCCAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCA
AGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCGGGGGGCGGCAGCAGCAGGCA
CGAGAAGAGCCTGGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGA
CGGCGTTCTGGATCTCAAAGCGGCTGCTGATACTTTGGCTGTGAGGCAAAAAAGGAGAAT
TTATGATATCACCAATGTCTTAGAGGGAATTGACTTGATTGAAAAAAAGTCAAAAAACAG
TATCCAGTGGAAAGGTGTANGTGCTGGCTGTAATACTAAAGAAGTCATAGATAGATTAAG
ATATCTTAAAGCTGAAATTGAAGATCTAGAACTGAAGGAAAGAGAACTTGATCAGCAGAA
GTTGTGGCTACAGCAAAGCATCAAAAATGTGATGGACGATTCCATTAATAATAGATTTTC
CTATGTAACTCATGAAGACATCTGTNATTGCTNTAATGGTGATACACTTTTGGCCATTCA
GGCACCTTCTGGTACACAACTGGNAGTACCCCATCCANAAATGGGTCAGAATGACAANAG
AATACCAGATCAATCTAAGAATCATTCAGACCTATCCTGTGCTGCTTATAATAAAGATCC
ATTCATCTAGCCCGTGGTTTTTCTGTCCCCCACTGATGACTACCAGNCTNCTCCAGTCCT
GACTCCCGGACTCCCCAAATCCGCTGGCACTCAAACTGC
>OriGene 3' read for NM_001951 unedited
NTAATTCAGNACGCGGCCGCATTCTANGATCAGTTTTTTTTTTTTTTTTTTGAATGTTTT
ATACAATTTTATTTTTAAAAATCTTGTTAATGTACAGGCATTGGCACATTTTAAAAACAA
ACTACATAAACAGATCTTTCCTATAACCTAGGAAAGTGGAATGTCAGAAGTCAACAAAAT
GTGATAAACTTAAAGTGCTAAAACAGAAGGCACTTCACAAAATCTGTTCACTGAAACAGT
TATATATCCTCGTTTACATCCTTCACTTTACAAGTGGCAGTGAACGTCTGTTTGGATAGA
AGGACATACAGAAATACAGGCAGTTTAGTGGCAGTAAAAATATAAGACAAGTAATGAGTC
CTTGGCCAACTTGTTTTTGATGACCTGTAGTGTCCTTTAACTTTCCTCCTTAAGAAGAAA
AAACAGAAGGATTCACAATTAGAAGAAAAGTTGAAATCCAGAATATAGTTACTTTTGGGA
GTGGGGACGTTTGTGGATATTAAATCACTTATCCCCTAAAGCAATCAGAGCCCTTTGTTT
TTATGGTTGAAGTTTTGTGAAGTAAAGAAAGTATTAGGGAAGAACACTTCAGAATCAGTG
AACTAAAAAAGGTGTTACATTCCTTATTTTAAATATTTAGGTTATTAAGAAGGCCAAAAT
GTTACCCAGTTAGAGGTAGATAACAGTCCCAAGTTTTCCTGGAAATCTAAAATTTAATAT
CCTGGACATCAAAAAAAATCACAAACTCCTTCGGTATCCTCCAAAATAAAGGTTGGAGTC
CTCCGGCCCGGGTAAGGGGAAAGCCCTAAAAAAAGGAAACCCCCCGAAGAACATTACTCA
CCAATGAAATCTCCACCAAAAAATCCGGGTGAAAAAATAACCTGGAACTGATGTCTGCTG
CCGAACCTGGGTTTCTT
Restriction Sites NotI-NotI     
ACCN NM_001951
ORF Size 1041 bp
Insert Size 1700
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_001951.2, NP_001942.1
RefSeq Size 1752
RefSeq ORF 1041
Locus ID 1875
Domains E2F_TDP
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Cell cycle, TGF-beta signaling pathway
Gene Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

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