p63 (TP63) (NM_003722) Human Untagged Clone

CAT#: SC128232

TP63 (untagged)-Human tumor protein p63 (TP63), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TP63
• Synonyms: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC128232 sequence for NM_003722 edited (data generated by NextGen Sequencing)
  ATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAG
  CGTTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATG
  TCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGAT
  TTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCA
  TCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAGGAC
  TCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATG
  GACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAG
  AACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCT
  CCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCC
  TTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGTATTCCACTGAACTGAAGAAA
  CTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCTCCT
  CAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTG
  GTGAAGCGGTGCCCCAACCATGAGCTGAGCCGTGAATTCAACGAGGGACAGATTGCCCCT
  CCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATC
  ACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACG
  ACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCA
  ATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGCTTT
  GAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGA
  AAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAG
  AACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAACTG
  TTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCC
  CTGGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAG
  CAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATATGGT
  AACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAG
  CTTATCAACCCTCAGCAGCGCAACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGA
  GCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTCAGC
  CCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCA
  CCTCCGTATCCCACAGATTGCAGCATTGTCAGTTTCTTAGCGAGGTTGGGCTGTTCATCA
  TGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTATCAGATTGAGCATTACTCC
  ATGGATGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGC
  ATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCA
  AGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGAT
  GCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGAC
  TTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAG
  TGA
  
  Clone variation with respect to NM_003722.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003722 unedited
  NCGTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNATTCAAATCTGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGCCCGGCTTTATATCTATATATACACA
  GGTATATGTGTATATTTTATATAATTGTTCTCCGTTCGTTGATATCAAAGACAGTTGAAG
  GAAATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATC
  CAGCGTTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
  ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGG
  GATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAA
  CCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
  GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGC
  ATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCG
  CAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
  TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTG
  TCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGTATTCCACTGAACTGAAG
  AAACTCTACTGCCAAATTGCANAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
  CCTCAGGGAGCTNGTATCCGCGCCATGCCTGTCTACAAAAAGCTGAGCACGTCACGNAGG
  TGGTGAACCGTGCCCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003722 unedited
  CCTTGGGGATGGCAACTTCCAGGCCAGNAGAGCACTGGGGNAGGGNNTCACAGGGNATGC
  CCACCCGGGNATNCTGTTNCAGGNAAACAGCTATGACCGCGGCCGCAATCTAGATACCTA
  TCACCATACATGATACCCCTTAAGGGAAGGAGTATAGACAAGCCATCCAAAACAAGTAAA
  TTAAAAAATGGTCAATAAGTGCAACTCAATTTTCTTTCATTTAAATTACATTTTAAACAA
  TACTCAATGCCCCCCACCCAAAAATCTATACTGTATATTTATACATTTATATATATAGTC
  TTAGACTATAAGGGTGAACATGCTTTATAAAAGTCAATGAGAAATCTCTGCAGCTTAAGG
  AGACACCCAACTCTTTTTTGCTCACTTCTACCTAGCCATGGCAGCTACAGTTCTGCAAGC
  TATAGTTTTGAAGGCTTAAAGCCAGAATCAGAATTAGATGCCAGGTCAGATGTTAGGTAA
  GAGGTAGCCTCTTACTTCTCCTTCCCCTAAGAAATCAGACAAGAGGAAGGGGAGGAGCTA
  GGGAGAAGGCTTTGAAGATTAAGCAGGAGTGCTTTTAGGGGGCTGGCAGTTAGGAGAGGG
  ATAGGAAGAGCTCACATGGTGAGGCTCACTCCCCCTCCTCTTTGATGCGCTGTTGCTTAT
  TGCGGCGAGCATCCATGTCAAAGTTGAAGTCATTCCACTCATCTCGGGGTGGGAAAGAGA
  TGGTCTGGGCGGAGGTGAATCGCACAGCATCAATAACACGCTCACCCCGGGTCTCACTGG
  AGCCCACACTGACTGTAGAGGCACTGCTTGGNGTCCGCAGNAGATGAAGAAGGGAGGAGA
  ATTCNTGGAGCTTGCGGTGGGTCCAGATGCCCTTTCAGATCGCATGTTCAAATTGCT
  
• Restriction Sites: Please inquire
• ACCN: NM_003722
• ORF Size: 2043 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003722.3, NP_003713.3
• RefSeq Size: 4932
• RefSeq ORF: 2043
• Locus ID: 8626
• Domains: SAM, P53
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
  Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1, also known as TAp63alpha, TA-alpha, KET, and p51B). This isoform is expressed in female germ cells and acts to protect the germline by eliminating oocytes that have suffered DNA damage.