alpha Synuclein (SNCA) (NM_007308) Human Untagged Clone

CAT#: SC128245

SNCA (untagged)-Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4


  "NM_007308" in other vectors (6)

Reconstitution Protocol

USD 420.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SNCA
Synonyms NACP; PARK1; PARK4; PD1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_007308 edited
CTTCTGCCTTTCCACCCTCGTGAGCGGAGAACTGGGAGTGGCCATTCGACGACAGTGTGG
TGTAAAGGAATTCATTAGCCATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGG
GAGTTGTGGCTGCTGCTGAGAAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGACAA
AAGAGGGTGTTCTCTATGTAGGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGGCAA
CAGTGGCTGAGAAGACCAAAGAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGGGTG
TGACAGCAGTAGCCCAGAAGACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTGGCT
TTGTCAAAAAGGACCAGTTGGGCAAGGAAGGGTATCAAGACTACGAACCTGAAGCCTAAG
AAATATCTTTGCTCCCAGTTTCTTGAGATCTGCTGACAGATGTTCCATCCTGTACAAGTG
CTCAGTTCCAATGTGCCCAGTCATGACATTTCTCAAAGTTTTTACAGTGTATCTCGAAGT
CTTCCATCAGCAGTGATTGAAGTATCTGTACCTGCCCCCACTCAGCATTTCGGTGCTTCC
CTTTCACTGAAGTGAATACATGGTAGCAGGGTCTTTGTGTGCTGTGGATTTTGTGGCTTC
AATCTACGATGTTAAAACAAATTAAAAACACCTAAGTGACTACCACTTATTTCTAAATCC
TCACTATTTTTTTGTTGCTGTTGTTCAGAAGTTGTTAGTGATTTGCTATCATATATTATA
AGATTTTTAGGTGTCTTTTAATGATACTGTCTAAGAATAATGACGTATTGTGAAATTTGT
TAATATATATAATACTTAAAAATATGTGAGCATGAAACTATGCACCTATAAATACTAAAT
ATGAAATTTTACCATTTTGCGATGTGTTTTATTCACTTGTGTTTGTATATAAATGGTGAG
AATTAAAATAAAACGTTATCTCATTGCAAAAATAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_007308 unedited
GTTCAGTTCACAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCCTC
GTGCCGAATTCGGCACGAGGCTTCTGCCTTTCCACCCTCGTGAGCGGAGAACTGGGAGTG
GCCATTCGACGACAGTGTGGTGTAAAGGAATTCATTAGCCATGGATGTATTCATGAAAGG
ACTTTCAAAGGCCAAGGAGGGAGTTGTGGCTGCTGCTGAGAAAACCAAACAGGGTGTGGC
AGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTATGTAGGCTCCAAAACCAAGGAGGG
AGTGGTGCATGGTGTGGCAACAGTGGCTGAGAAGACCAAAGAGCAAGTGACAAATGTTGG
AGGAGCAGTGGTGACGGGTGTGACAGCAGTAGCCCAGAAGACAGTGGAGGGAGCAGGGAG
CATTGCAGCAGCCACTGGCTTTGTCAAAAAGGACCAGTTGGGCAAGGAAGGGTATCAAGA
CTACGAACCTGAAGCCTAAGAAATATCTTTGCTCCCAGTTTCTTGAGATCTGCTGACAGA
TGTTCCATCCTGTACAAGTGCTCAGTTCCAATGTGCCCAGTCATGACATTTCTCANAGTT
TTTACAGTGTATCTCGAAGTCNTCCATCAGCAGTGATTGAAGTATCTGTACCTGCCCCAC
TCAGCATTNTCGTGCTTCCCTTTCACTGAAGTGAATACATGGTAGCAGGNTCTTTGTGTG
CTGTGGATTTTGTGGCTTTCATCTACGATGGTAAAACCAATTANAAACACCCTAGTGACT
ACCACTTATTTCTAAATCCTCACTATTTTTTTGTTGCTGGTTGTCAAAAGTGGTAGTGAT
TTGCTATCATATATAATAAGATTTTTAGTGTCTTTTAATGAAACTGGCTAGAATTATGAC
CTATTGA
>OriGene 3' read for NM_007308 unedited
NCCCCTCGGAATGGCAACTTCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGC
CACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTT
TTTTTTTTTTTTTATTTTTGCAATGAGATAACGTTTTATTTTAATTCTCACCATTTATAT
ACAAACACAAGTGAATAAAACACATCGCAAAATGGTAAAATTTCATATTTAGTATTTATA
GGTGCATAGTTTCATGCTCACATATTTTTAAGTATTATATATATTAACAAATTTCACAAT
ACGTCATTATTCTTAGACAGTATCATTAAAAGACACCTAAAAATCTTATAATATATGATA
GCAAATCACTAACAACTTCTGAACAACAGCAACAAAAAAATAGTGAGGATTTAGAAATAA
GTGGTAGTCACTTAGGTGTTTTTAATTTGTTTTAACATCGTAGATTGAAGCCACAAAATC
CACAGCACACAAAGACCCTGCTACCATGTATTCACTTCAGTGAAAGGGAAGCACCGAAAT
GCTGAGTGGGGGCAGGTACAGATACTTCAATCACTGCTGATGGAAGACTTCGAGATACAC
TGTAAAAACTTTGAGAAATGTCATGACTGGGCACATTGGAACTGAGCACTTGTACAGGAT
GGAACATCTGTCAGCAGATCTCAAGAAACTGGGAGCAAAGATATTTCTTAGGCTTCAGGT
TCGTAGTCTTGATACCCTTCCTTGCCCAACTGGTCCTTTTTGACAAACCAGTGGCTGCTG
CAATGCTCCCTGCTCCCTCCACTGTCTTCTGGGCTACTGCTGTCACACCCGTCACCACTG
GCTCTCCAACATTTGTCACTTGCTCTTTGGGTCTCTCAGCCCTGTTGCCACACATGCACA
CTCCTNCTTGG
Restriction Sites Please inquire     
ACCN NM_007308
Insert Size 1000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_007308.1, NP_009292.1
RefSeq Size 1096 bp
RefSeq ORF 339 bp
Locus ID 6622
Cytogenetics 4q22.1
Domains Synuclein
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease
Gene Summary 'Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]'
Transcript Variant: This variant (4, also known as NACP112) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (NACP112) has the same N- and C-termini but is shorter compared to isoform NACP140. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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