IL15 (NM_172174) Human Untagged Clone

CAT#: SC128246

IL15 (untagged)-Human interleukin 15 (IL15), transcript variant 1


  "NM_172174" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL15
Synonyms IL-15; Interleukin 15; MGC9721; OTTHUMP00000164617
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_172174 edited
ACTCCGGGTGGCAGGCGCCCGGGGGAATCCCAGCTGACTCGCTCACTGCCTTCGAAGTCC
GGCGCCCCCCGGGAGGGAACTGGGTGGCCGCACCCTCCCGGCTGCGGTGGCTGTCGCCCC
CCACCCTGCAGCCAGGACTCGATGGAGGTACAGAGCTCGGCTTCTTTGCCTTGGGAGGGG
AGTGGTGGTGGTTGAAAGGGCGATGGAATTTTCCCCGAAAGCCTACGCCCAGGGCCCCTC
CCAGCTCCAGCGTTACCCTCCGGTCTATCCTACTGGCCGAGCTGCCCCGCCTTCTCATGG
GGAAAACTTAGCCGCAACTTCAATTTTTGGTTTTTCCTTTAATGACACTTCTGAGGCTCT
CCTAGCCATCCTCCCGCTTCCGGAGGAGCGCAGATCGCAGGTCCCTTTGCCCCTGGCGTG
CGACTCCCTACTGCGCTGCGCTCTTACGGCGTTCCAGGCTGCTGGCTAGCGCAAGGCGGG
CCGGGCACCCCGCGCTCCGCTGGGAGGGTGAGGGACGCGCGTCTGGCGGCCCCAGCCAAG
CTGCGGGTTTCTGAGAAGACGCTGTCCCGCAGCCCTGAGGGCTGAGTTCTGCACCCAGTC
AAGCTCAGGAAGGCCAAGAAAAGAATCCATTCCAATATATGGCCATGTGGCTCTTTGGAG
CAATGTTCCATCATGTTCCATGCTGCTGACGTCACATGGAGCACAGAAATCAATGTTAGC
AGATAGCCAGCCCATACAAGATCGTATTGTATTGTAGGAGGCATCGTGGATGGATGGCTG
CTGGAAACCCCTTGCCATAGCCAGCTCTTCTTCAATACTTAAGGATTTACCGTGGCTTTG
AGTAATGAGAATTTCGAAACCACATTTGAGAAGTATTTCCATCCAGTGCTACTTGTGTTT
ACTTCTAAACAGTCATTTTCTAACTGAAGCTGGCATTCATGTCTTCATTTTGGGCTGTTT
CAGTGCAGGGCTTCCTAAAACAGAAGCCAACTGGGTGAATGTAATAAGTGATTTGAAAAA
AATTGAAGATCTTATTCAATCTATGCATATTGATGCTACTTTATATACGGAAAGTGATGT
TCACCCCAGTTGCAAAGTAACAGCAATGAAGTGCTTTCTCTTGGAGTTACAAGTTATTTC
ACTTGAGTCCGGAGATGCAAGTATTCATGATACAGTAGAAAATCTGATCATCCTAGCAAA
CAACAGTTTGTCTTCTAATGGGAATGTAACAGAATCTGGATGCAAAGAATGTGAGGAACT
GGAGGAAAAAAATATTAAAGAATTTTTGCAGAGTTTTGTACATATTGTCCAAATGTTCAT
CAACACTTCTTGATTGCAATTGATTCTTTTTAAAGTGTTTCTGTTATTAACAAACATCAC
TCTGCTGCTTAGACATAACAAAACACTCGGCATTTCAAATGTGCTGTCAAAACAAGTTTT
TCTGTCAAGAAGATGATCAGACCTTGGATCAGATGAACTCTTAGAAATGAAGGCAGAAAA
ATGTCATTGAGTAATATAGTGACTATGAACTTCTCTCAGACTTACTTTACTCATTTTTTT
AATTTATTATTGAAATTGTACATATTTGTGGAATAATGTAAAATGTTGAATAAAAATATG
TACAAGTGTTGTTTTTTAAGTTGCACTGATATTTTACCTCTTATTGCAAAATAGCATTTG
TTTAAGGGTGATAGTCAAATTATGTATTGGTGGGGCTGGGTACCAATGCTGCAGGTCAAC
AGCTATGCTGGTAGGCTCCTGCCTGTGTGGAACCACTGACTACTGGCTCTCATTGACTTC
CTTACTAAGCATAGCAAACAGAGGAAGAATTTGTTATCAGTAAGAAAAAGAAGAACTATA
TGTGAATCCTCTTCTTTACACTGTAATTTAGTTATTGATGTATAAAGCAACTGTTATGAA
ATAAAGAAATTGCAATAACTGGCAAAAAAAAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_172174 unedited
NGGTCCAGTTCATAATTGTATACGACTCATATAGGCGGCCGCGNATTCCCGGGATATCGT
CGACCCAGCGTCCGCCCCGCGTCCGACTCCGGGTGGCAGGCGCCCGGGGGAATCCCAGCT
GACTCGCTCACTGCCTTCGAAGTCCGGCGCCCCCCGGGAGGGAACTGGGTGGCCGCACCC
TCCCGGCTGCGGTGGCTGTCGCCCCCCACCCTGCAGCCAGGACTCGATGGAGGTACAGAG
CTCGGCTTCTTTGCCTTGGGAGGGGAGTGGTGGTGGTTGAAAGGGCGATGGAATTTTCCC
CGAAAGCCTACGCCCAGGGCCCCTCCCAGCTCCAGCGTTACCCTCCGGTCTATCCTACTG
GCCGAGCTGCCCCGCCTTCTCATGGGGAAAACTTAGCCGCAACTTCAATTTTTGGTTTTT
CCTTTAATGACACTTCTGAGGCTCTCCTAGCCATCCTCCCGCTTCCGGAGGAGCGCAGAT
CGCAGGTCCCTTTGCCCCTGGCGTGCGACTCCCTACTGCGCTGCGCTCTTACGGCGTTCC
AGGCTGCTGGCTAGCGCAAGGCGGGCCGGGCACCCCGCGCTCCGCTGGGAGGGTGAGGGA
CGCGCGTCTGGCGGCCCCAGCCAAGCTGCGGGTTTCTGAGAAGACGCTGTCCCGCAGCCC
TGAGGGCTGAGTTCTGCACCCAGTCAAGCTCAGGAAGGCCAAGAAAAGAATCCATTCCAA
TATATGGCCATGTGGCTCTTTGGAGCAATGTTCCATCATGTTCCATGCTGCTGACGTCAC
ATGGAGCACAGAAATCAATGTTAGCAGATAGCCAGCCCATACAAGATCGTATTGTATTGT
ANGAGGCATCGTGGATGGATGGCTGCTGG
Restriction Sites Please inquire     
ACCN NM_172174
Insert Size 2000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_172174.1, NP_751914.1
RefSeq Size 1969 bp
RefSeq ORF 489 bp
Locus ID 3600
Cytogenetics 4q31.21
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Gene Summary 'The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]'
Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 3 encode the same protein.

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