FGFR4 (NM_022963) Human Untagged Clone

CAT#: SC128287

FGFR4 (untagged)-Human fibroblast growth factor receptor 4 (FGFR4), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FGFR4
• Synonyms: CD334; JTK2; TKF
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_022963 edited
  GAATTCGGCACGAGGCCGAGGAGCGCTCGGGCTGTCTGCGGACCCTGCCGCGTGCAGGGG
  TCGCGGCCGGCTGGAGCTGGGAGTGAGGCGGCGGAGGAGCCAGGTGAGGAGGAGCCAGGA
  AGGCAGTTGGTGGGAAGTCCAGCTTGGGTCCCTGAGAGCTGTGAGAAGGAGATGCGGCTG
  CTGCTGGCCCTGTTGGGGGTCCTGCTGAGTGTGCCTGGGCCTCCAGTCTTGTCCCTGGAG
  GCCTCTGAGGAAGTGGAGCTTGAGCCCTGCCTGGCTCCCAGCCTGGAGCAGCAAGAGCAG
  GAGCTGACAGTAGCCCTTGGGCAGCCTGTGCGGCTGTGCTGTGGGCGGGCTGAGCGTGGT
  GGCCACTGGTACAAGGAGGGCAGTCGCCTGGCACCTGCTGGCCGTGTACGGGGCTGGAGG
  GGCCGCCTAGAGATTGCCAGCTTCCTACCTGAGGATGCTGGCCGCTACCTCTGCCTGGCA
  CGAGGCTCCATGATCGTCCTGCAGAATCTCACCTTGATTACAGGTGACTCCTTGACCTCC
  AGCAACGATGATGAGGACCCCAAGTCCCATAGGGACCTCTCGAATAGGCACAGTTACCCC
  CAGCAAGCACCCTACTGGACACACCCCCAGCGCATGGAGAAGAAACTGCATGCAGTACCT
  GCGGGGAACACCGTCAAGTTCCGCTGTCCAGCTGCAGGCAACCCCACGCCCACCATCCGC
  TGGCTTAAGGATGGACAGGCCTTTCATGGGGAGAACCGCATTGGAGGCATTCGGCTGCGC
  CATCAGCACTGGAGTCTCGTGATGGAGAGCGTGGTGCCCTCGGACCGCGGCACATACACC
  TGCCTGGTAGAGAACGCTGTGGGCAGCATCCGTTATAACTACCTGCTAGATGTGCTGGAG
  CGGTCCCCGCACCGGCCCATCCTGCAGGCCGGGCTCCCGGCCAACACCACAGCCGTGGTG
  GGCAGCGACGTGGAGCTGCTGTGCAAGGTGTACAGCGATGCCCAGCCCCACATCCAGTGG
  CTGAAGCACATCGTCATCAACGGCAGCAGCTTCGGAGCCGACGGTTTCCCCTATGTGCAA
  GTCCTAAAGACTGCAGACATCAATAGCTCAGAGGTGGAGGTCCTGTACCTGCGGAACGTG
  TCAGCCGAGGACGCAGGCGAGTACACCTGCCTCGCAGGCAATTCCATCGGCCTCTCCTAC
  CAGTCTGCCTGGCTCACGGTGCTGCCAGGTACTGGGCGCATCCCCCACCTCACATGTGAC
  AGCCTGACTCCAGCAGGCAGAACCAAGTCTCCCACTTTGCAGTTCTCCCTGGAGTCAGGC
  TCTTCCGGCAAGTCAAGCTCATCCCTGGTACGAGGCGTGCGTCTCTCCTCCAGCGGCCCC
  GCCTTGCTCGCCGGCCTCGTGAGTCTAGATCTACCTCTCGACCCACTATGGGAGTTCCCC
  CGGGACAGGCTGGTGCTTGGGAAGCCCCTAGGCGAGGGCTGCTTTGGCCAGGTAGTACGT
  GCAGAGGCCTTTGGCATGGACCCTGCCCGGCCTGACCAAGCCAGCACTGTGGCCGTCAAG
  ATGCTCAAAGACAACGCCTCTGACAAGGACCTGGCCGACCTGGTCTCGGAGATGGAGGTG
  ATGAAGCTGATCGGCCGACACAAGAACATCATCAACCTGCTTGGTGTCTGCACCCAGGAA
  GGGCCCCTGTACGTGATCGTGGAGTGCGCCGCCAAGGGAAACCTGCGGGAGTTCCTGCGG
  GCCCGGCGCCCCCCAGGCCCCGACCTCAGCCCCGACGGTCCTCGGAGCAGTGAGGGGCCG
  CTCTCCTTCCCAGTCCTGGTCTCCTGCGCCTACCAGGTGGCCCGAGGCATGCAGTATCTG
  GAGTCCCGGAAGTGTATCCACCGGGACCTGGCTGCCCGCAATGTGCTGGTGACTGAGGAC
  AATGTGATGAAGATTGCTGACTTTGGGCTGGCCCGCGGCGTCCACCACATTGACTACTAT
  AAGAAAACCAGCAACGGCCGCCTGCCTGTGAAGTGGATGGCGCCCGAGGCCTTGTTTGAC
  CGGGTGTACACACACCAGAGTGACGTGTGGTCTTTTGGGATCCTGCTATGGGAGATCTTC
  ACCCTCGGGGGCTCCCCGTATCCTGGCATCCCGGTGGAGGAGCTGTTCTCGCTGCTGCGG
  GAGGGACATCGGATGGACCGACCCCCACACTGCCCCCCAGAGCTGTACGGGCTGATGCGT
  GAGTGCTGGCACGCAGCGCCCTCCCAGAGGCCTACCTTCAAGCAGCTGGTGGAGGCGCTG
  GACAAGGTCCTGCTGGCCGTCTCTGAGGAGTACCTCGACCTCCGCCTGACCTTCGGACCC
  TATTCCCCCTCTGGTGGGGACGCCAGCAGCACCTGCTCCTCCAGCGATTCTGTCTTCAGC
  CACGACCCCCTGCCATTGGGATCCAGCTCCTTCCCCTTCGGGTCTGGGGTGCAGACATGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022963 unedited
  GTGGGATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGGCACGAGGCCGAGGAGCG
  CTCGGGCTGTCTGCGGACCCTGCCGCGTGCAGGGGTCGCGGCCGGCTGGAGCTGGGAGTG
  AGGCGGCGGAGGAGCCAGGTGAGGAGGAGCCAGGAAGGCAGTTGGTGGGAAGTCCAGCTT
  GGGTCCCTGAGAGCTGTGAGAAGGAGATGCGGCTGCTGCTGGCCCTGTTGGGGGTCCTGC
  TGAGTGTGCCTGGGCCTCCAGTCTTGTCCCTGGAGGCCTCTGAGGAAGTGGAGCTTGAGC
  CCTGCCTGGCTCCCAGCCTGGAGCAGCAAGAGCAGGAGCTGACAGTAGCCCTTGGGCAGC
  CTGTGCGGCTGTGCTGTGGGCGGGCTGAGCGTGGTGGCCACTGGTACAAGGAGGGCAGTC
  GCCTGGCACCTGCTGGCCGTGTACGGGGCTGGAGGGGCCGCCTAGAGATTGCCAGCTTCC
  TACCTGAGGATGCTGGCCGCTACCTCTGCCTGGCACGAGGCTCCATGATCGTCCTGCAGA
  ATCTCACCTTGATTACAGGTGACTCCTTGACCTCCAGCAACGATGATGAGGACCCCAAGT
  CCCATAGGGACCTCTCGAATAGGCACAGTTACCCCCAGCAAGCACCCTACTGGACACACC
  CCCAGCGCATGGAGAAGAAACTGCATGCAGTACCTGCGGGGAACACCGTCAAGTTCCGCT
  GTCCAGCTGCAGGCAACCCCACGCCCACCATCCGCTGGCTTAAAGATGGACAGGCCTTTC
  ATGGGGAGAACCGCATTGGAGGCATTCGCTGCGCCATCAGCACTGGAGTCTCGTGATGGA
  GAGCGTGTGCCCTCGGACCGCGCACATACACCTGCCTGGTAGAGAACGCTGTGGGCAGCA
  TCCGTTATAACTACCTGCTAGATGTGCTGGAGCGGTCCCCGCACCGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_022963 unedited
  GGGTGTGTATAAAACGCCTTTGCTCCTGTTTTGCGGCAGGCTTCCAGCTTCTCTGGGCTC
  AGGGGCCAATGCTCCCGTCAAGACGCTGGGGCAGCAGCAGCAGGGGGAGGTGTGGGGAAA
  GGGGGTTCAGAGGCCCAGAACCTCCTGCTGGTATTGGGAGGCAGGAGGTTTAGCATAGCA
  GCTCTCCAGCCAGGCTCAGCCAAACCCGGGATGGGGACTAAGCGCCAAGGTCCAAGAAGC
  CGAGCAGAACCCTGACATTTGGGCCATCAGGACACAGGCACGGCAGCTCCAAGGGCAAGG
  GCACGGCCCTTGGACACGGCACAGCAACTCTGGGCCAGGGGCCCCATGCTATCAAGGTCG
  AGCACTGTGTCAGGCTGTGGCTGAGCCCCAAGGCCCAAGGCCACCAGCCTATGTGCCTGC
  ACAGCCTTGAGCCTTGCTCATGTCTGCACCCCAGACCCGAAGGGGAAGGAGCTGGATCCC
  AATGGCAGGGGGTCGTGGCTGAAGACAGAATCGCTGGAGGAGCAGGTGCTGCTGGCGTCC
  CCACCAGAGGGGGAATAGGGTCCGAAGGTCAGGCGGAGGTCGAGGTACTCCTCAGAGACG
  GCCAGCAGGACCTTGTCCAGCGCCTCCACCAGCTGCTTGAAGGTAGGCCTCTGGGAGGGC
  GCTGCGTGCCAGCACTCACGCATCAGCCCCGTACAGCTCTGGGGGGCAGTGTGGGGGTCG
  GTCCATCCGATGTCCCTCCCGCAGCAGCGAGAACAGCTCCTCCACCGGGATGCCAGGATA
  CGGGGAGCCCCCGAGGGTGAAGATCTCCCATAGCAGGATCCCAAAAGACCACCACGTCAC
  TCTGGTGTGTGTACACCGGTCAAACAAGGCCTCGGGCGCATCCACTTCACAGGCAGCGCC
  GTGCTGGTTTTCCTAATAGTAGTCAATGGTGGTGGACGCCCGCGGGGCCAGCCCAAAGTC
  AGCAAATCC
  
• Restriction Sites: Please inquire
• ACCN: NM_022963
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_022963.2, NP_075252.2
• RefSeq Size: 2807 bp
• RefSeq ORF: 2289 bp
• Locus ID: 2264
• Cytogenetics: 5q35.2
• Domains: pkinase, TyrKc, S_TKc, ig, IGc2, IG
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton
• Gene Summary: 'The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]'
  Transcript Variant: This variant (2) lacks an internal exon but has an alternate segment in the central coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter internal segment, compared to isoform 1, and it is missing the transmembrane region, suggesting a soluble rather than membrane-bound receptor.