GNA11 (NM_002067) Human Untagged Clone

CAT#: SC303115

GNA11 (untagged)-Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GNA11
• Synonyms: FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002067 edited
  ATGACTCTGGAGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGG
  ATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTC
  AAGCTGCTGCTGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGC
  ATCATCCACGGCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTAC
  CAGAACATCTTCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTC
  TACAAGTACGAGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAG
  GTGACCACCTTCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGC
  ATCCAGGAATGCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTAC
  CTGACCGACGTTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTG
  CGGGTCCGCGTGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATC
  TTCCGGATGGTGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTT
  GAGAACGTGACATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTG
  GAGTCGGACAACGAGAACCGGATGGAGGAGAGCAAAGCCCTGTTCCGGACTATCATCACC
  TACCCCTGGTTCCAGAACTCCTCCGTCATCCTCTTCCTCAACAAGAAGGACCTGCTGGAG
  GACAAGATCCTGTACTCGCACCTGGTGGACTACTTCCCCGAGTTCGATGGTCCCCAGCGG
  GACGCCCAGGCGGCGCGGGAGTTCATCCTGAAGATGTTCGTGGACCTGAACCCCGACAGC
  GACAAGATCATCTACTCACACTTCACGTGTGCCACCGACACGGAGAACATCCGCTTCGTG
  TTCGCGGCCGTGAAGGACACCATCCTGCAGCTCAACCTCAAGGAGTACAACCTGGTCTGA
  GCGCCCAGGCCCAGGGAGACGGGATGGAGACACGGGGCAGGACCTTCCTTCCACGGAGCC
  TGCGGCTGCCGGGCGGGTGGCGCTGCCGAGTCCGGGCCGGGGCCTCTGCCCGCGGGAGGA
  GATTTTTTTTTTTCATATTTTTAACAAATGGTTTTTATTTCACAGTTATCAGGGGATGTA
  CATCTCTCCCTCCGTACACTTCGCGCACCTTCTCACCTTTTGTCAACGGCAAAGGCAGCC
  TTTTTCTGGCCTTGACTTATGGCTCGCTTTTTTCTAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002067 unedited
  GTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGATGACTCTGG
  AGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCG
  AGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTCAAGCTGCTGC
  TGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGCATCATCCACG
  GCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTACCAGAACATCT
  TCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTCTACAAGTACG
  AGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAGGTGACCACCT
  TCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGCATCCAGGAAT
  GCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTACCTGACCGACG
  TTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTGCGGGTCCGCG
  TGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATCTTCCGGATGG
  TGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTTGAGAACGTGA
  CATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTGGAGTCNGACA
  ACGAGAACCGGATGGGAGGAGAGCAAGCCCTGTTCCGGACTATCATCACCTACCCCTGGT
  TCCAGAACTNCTNCGTCATCCTCTTTCTCAACAGAAGGACCTGCTGNAGGACAGATCCTG
  TACTCGCACN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002067 unedited
  CCCATTGAGATGGCACTTCCAGGTCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCCA
  CCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTT
  TTTTTTTTTTTAGAAAAAAGCGAGCCATAAGTCAAGGCCAGAAAAAGGCTGCCTTTGCCG
  TTGACAAAAGGTGAGAAGGTGCGCGAAGTGTACGGAGGGAGAGATGTACATCCCCTGATA
  ACTGTGAAATAAAAACCATTTGTTAAAAATATGAAAAAAAAAAATCTCCTCCCGCGGGCA
  GAGGCCCCGGCCCGGACTCGGCAGCGCCACCCGCCCGGCAGCCGCAGGCTCCGTGGAAGG
  AAGGTCCTGCCCCGTGTCTCCATCCCGTCTCCCTGGGCCTGGGCGCTCAGACCAGGTTGT
  ACTCCTTGAGGTTGAGCTGCAGGATGGTGTCCTTCACGGCCGCGAACACGAAGCGGATGT
  TCTCCGTGTCGGTGGCACACGTGAAGTGTGAGTAGATGATCTTGTCGCTGTCGGGGTTCA
  GGTCCACGAACATCTTCAGGATGAACTCCCGCGCCGCCTGGGCGTCCCGCTGGGGACCAT
  CGAACTCGGGGAAGTAGTCCACCAGGTGCGAGTACAGGATCTTGTCCTCCAGCAGGTCCT
  TCTTGTTGAGGAAGAGGATGACGGGAGAGTTCTGGAACCAGGGGTAGGTGATGATAGTCC
  GGAACAGGGCTTTGCTCTCCTCCATCCGGTTCTCGTTGTCCGACTCCACCAGACTTGGTC
  GTATTCGCTGAAGGCGACCAGGAACATGATGGATGTCACGTTCTAAAGCAGGGGATCCAT
  TTCTTCGGTTCGACCGTTTGGCCCCCCACTTCACCATTCGGAAGATGTTGTTCTCCAGGT
  CGAAAGGTTCTC
  
• Restriction Sites: Please inquire
• ACCN: NM_002067
• Insert Size: 1400 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002067.1, NP_002058.1
• RefSeq Size: 1540 bp
• RefSeq ORF: 1080 bp
• Locus ID: 2767
• Cytogenetics: 19p13.3
• Protein Pathways: Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Vascular smooth muscle contraction
• Gene Summary: 'The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]'