beta Arrestin 1 (ARRB1) (NM_004041) Human Untagged Clone

CAT#: SC303424

ARRB1 (untagged)-Human arrestin, beta 1 (ARRB1), transcript variant 1


  "NM_004041" in other vectors (6)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ARRB1
Synonyms ARB1; ARR1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_004041 edited
CCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCC
TGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAA
ATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTGTGGACCACATCGACCTCGTGG
ACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATG
TGACGCTGACCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCT
TTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCCCACCGGCCCCCGAGGACAAGA
AGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTT
TCACCTTTGAGATCCCTCCAAACCTTCCATGTTCTGTGACACTGCAGCCGGGGCCCGAAG
ACACGGGGAAGGCTTGCGGTGTGGACTATGAAGTCAAAGCCTTCTGCGCGGAGAATTTGG
AGGAGAAGATCCACAAGCGGAATTCTGTGCGTCTGGTCATCCGGAAGGTTCAGTATGCCC
CAGAGAGGCCTGGCCCCCAGCCCACAGCCGAGACCACCAGGCAGTTCCTCATGTCGGACA
AGCCCTTGCACCTAGAAGCCTCTCTGGATAAGGAGATCTATTACCATGGAGAACCCATCA
GCGTCAACGTCCACGTCACCAACAACACCAACAAGACGGTGAAGAAGATCAAGATCTCAG
TGCGCCAGTATGCAGACATCTGCCTTTTCAACACAGCTCAGTACAAGTGCCCTGTTGCCA
TGGAAGAGGCTGATGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGA
CCCCCTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGC
ACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCC
TGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGT
TGGGAGATCTTGCATCCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCA
AGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCA
ATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGA
GACTGAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGC
TCAACAACAGATAGACGGGCCGGCCCTGCCTCCACGTGGCTCCGGCTCCACTCTCGTGCA
CTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTT
TCTACCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTG
GCCCCACATCACCACGCCAACAGGACCACAGCGCACTGGCTCCACCCCATCTCTGCCATC
TCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAA
TTGGACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGG
GCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCAAGACACGAGAGAAGATGTCCACGGT
CCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTT
CTGGCTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCA
CCAAAGACCTTCTGCCTTCACCCTCCTCCCCACCTGATGTCCCTCTGTGTCTGATAGTGA
TGTTGGTGAAAGTTCGTAGACCCCAGGAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_004041
Insert Size 2000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation ORF matches to NM_004041.3.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004041.3, NP_004032.2
RefSeq Size 2204 bp
RefSeq ORF 1257 bp
Locus ID 408
Cytogenetics 11q13.4
Protein Families Druggable Genome
Protein Pathways Chemokine signaling pathway, Endocytosis, MAPK signaling pathway
Gene Summary 'Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]'
Transcript Variant: This variant (1) represents the longer transcript variant and encodes the longer isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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