E2F2 (NM_004091) Human Untagged Clone

CAT#: SC303431

E2F2 (untagged)-Human E2F transcription factor 2 (E2F2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: E2F2
• Synonyms: E2F-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004091 edited
  GCCTTACTCGCTATGCTGCAAGGGCCCCGGGCCTTGGCTTCGGCCGCTGGGCAGACCCCG
  AAGGTGGTGCCCGCGATGAGCCCCACAGAGCTGTGGCCATCCGGCCTCAGCAGCCCCCAG
  CTCTGCCCAGCTACTGCTACCTACTACACACCGCTGTACCCGCAGACGGCGCCTCCCGCA
  GCGGCGCCAGGCACCTGCCTCGACGCCACTCCCCACGGACCCGAGGGCCAAGTTGTGCGA
  TGCCTGCCGGCAGGCCGGCTGCCGGCCAAAAGGAAGCTGGATCTGGAGGGGATTGGGAGG
  CCCGTCGTCCCTGAGTTCCCAACCCCCAAGGGGAAGTGCATCAGAGTGGATGGCCTCCCC
  AGCCCCAAAACCCCCAAATCCCCCGGGGAGAAGACTCGGTATGACACTTCGCTGGGGCTG
  CTCACCAAGAAGTTCATTTACCTCCTGAGCGAGTCAGAGGATGGGGTCCTGGACCTGAAC
  TGGGCCGCTGAGGTGCTGGACGTGCAGAAGCGGCGCATCTATGACATCACCAACGTGCTG
  GAAGGCATCCAGCTCATCCGCAAGAAGGCCAAGAACAACATCCAGTGGGTAGGCAGGGGA
  ATGTTTGAAGACCCCACCAGACCTGGGAAGCAGCAACAGCTGGGGCAGGAGCTGAAGGAG
  CTGATGAACACGGAGCAGGCCTTGGACCAKCTCATCCAGAGCTGCTCTCTGAGCTTCAAG
  CACCTGACTGAGGACAAGGCCAACAAGAGGCTGGCCTATGTGACTTACCAGGATATCCGT
  GCTGTTGGCAACTTTAAGGAGCAGACAGTGATTGCCGTCAAGGCCCCTCCGCAGACGAGA
  CTGGAAGTGCCCGACAGGACTGAGGACAACCTGCAGATATATCTCAAGAGCACCCAAGGG
  CCCATCGAAGTCTACCTGTGCCCAGAGGAGGTGCAGGAGCCGGACAGTCCTTCCGAGGAG
  CCTCTCCCCTCTACCTCCACCCTCTGCCCCAGCCCTGACTCTGCCCAGCCCAGCAGCAGC
  ACCGACCCTAGCATCATGGAGCCCACAGCATCCTCAGTGCCAGCACCAGCGCCAACCCCC
  CAGCAGGCCCCACCGCCTCCATCCCTGGTCCCCTTGGAGGCTACTGACAGCCTGCTGGAG
  CTGCCGCACCCACTCCTGCAGCAGACTGAGGACCAGTTCCTGTCCCCGACCCTGGCGTGC
  AGCTCCCCTCTGATCAGCTTCTCCCCATCCTTGGACCAGGACGACTACCTGTGGGGCTTG
  GAGGCGGGTGAGGGCATCAGCGATCTCTTCGACTCCTACGACCTTGGGGACCTGTTGATT
  AATTGAGTGGCCCCGCCTGCCCCCAGCAGCCTGCCCCCGACTCTACCTCCTCACAGACAG
  GCTGACAGCCCCTCTGCCTGCACAGGGACATTGGACACTAGGTGCTGCCCTCAGGGCATG
  GGGTCTCCTCGCCTTTCCTGCCCCAGCCGGCAGAAGCTGTGTGGGGAGATATGAATGGTA
  CGGGTGAGGAGTGGATAAGGGGTGGTCCTCACCTTCCTAATGGAAGCTGGGCCTAGGGAG
  GCCCATCCAGTCTTCTGACTTCTGACCTCTCACAAGAAGGCTGCAGGTGAGGTGGCCAAG
  TCCAGGGAAAGGCCCTGCTACCTCCTTTTGAGGGGTAATTAGGACCCTCGACGTACCAAG
  AAGCACATAATGCCTTTGTATTTATTTCAGGTTGAGTTGTTTGTTTGTCCTCCCTGAGTT
  TTAGCAGGGAGGTTGTTCTAGTTTTTAGTGAGACCTCTGCAGACAGGCCCATCACTGTCC
  ATGTTCCAGGGCAGGTCTGGGTTTCCAAGGGAGGGGCCCAGGCTACATCCTTGGTTTCCC
  CACTGTGGTGGGGGCTGGGACTCTGAGGGGCTGTCCAGTCTGCCAGAATGCTAATTGCAC
  TTAGGCCTCATGGTTCTAGTAAACGGCAGCTGTGGGCCCTTTTGCCTCTTCCCCTGTTCT
  TGGCCTCACATCTCCAGCTGAGCTGCCGGTCTTGGCTTCCTGGTCGCCTCTGTCCCAGAG
  ATGGTCCCAGGGAGCCATCCTAGGGCAGGTAGCACTGAGGCTCCTGTGGAAACAGGAGCC
  ACCTGCTCAGGAGACCCCTTTCCTGAGGAAGTCCTTACCTCTCCCCTTGAGATGTAAAAA
  TGGTCCAGCAGAGACAAGCTCCCGTGGAAAACAGACAGGAGCATGGGGGCAGCTGTCATG
  GCTGTGGCGGGCACTTTTCCTCAGAGTTTCTGCCTTGCGCTGGTCCAGGAGCCATTTTGC
  ACCAAGGACTTGGTAGGCAGAGGCAGCCCCACTGTAAAGAAGGGTCAGATTAAAACAAAA
  AACTGCCAAAAGCATCCCCTCTGCCCCCCATGTGGCACTGGCATCATTCTCTGCTTCCCT
  GGGAGGAATTTTTTCACCATGTTATTGAAGGGGATGGTTCATTAAGGACTCCACCCCTCA
  GAGCTCACTCAGACCCCAAGGACAGAGGTGACTGGGGCTTGGTGACTTGTTCACTCCTTT
  TTTCCCAGGTATACTGAAGGGGTGACAGAGAGAGGTCTTCATGGCAGACCAGGCCTTCAC
  AGCTAATGGGGAGAGGAACTCATGTTACCTCTGCAGGCCTGGGGTCCTGAGGGGGTCTTT
  TGGCTTCAGCCTGTTCCCCCAGAGGCTTGATCATCCCACATTGTCCCTTCAGCTCAGCTG
  CTCTTCTCCCCCACCCACCCTGGGATGTGGGTGCTCTGGGCTGAACCAAGGCTATGACTT
  CTGGAGAGAGGCTCAGGGGTTGGTCTGAGAGGCCTGCCATCCACCCCTCAGGGAGCTAGG
  TTTTCTCAGAGGCTCAGCTGGACAGCACTTTTTAGAAAAGTTTGTAGCATTAAGCTGGTT
  TAAAATATGAAGTTGGTTTTGTTGGATGGCTCCTGAGCTGACTGACTGATGTCTGAAGTT
  TGAGACGAGGGATTATTTCAGGGTGGGGCCCAATGTGATCTAATGCCCAGCTGGGGACAA
  TTGTGCCTCATCATTTGCTCAAATTCCTGGGCCCCCAAGTTAGCCCCCTCCCAGGAGTGG
  TCAGCGGGTCACAGCTGCCCCCACTCTATAAGCAGGGCTAATTGTGTACCCTTTGCAGAA
  ATGCTTTTGGTCTCCTACCCAAATACTCACAAGGGTCTTATCAGACGCCCGTCTTAAAGT
  CCAGCATGCTCAGGGACCCTGTGTAGGATCTTGTTTGTGGTGAGTGGGCTGCTCTGAGGT
  CTCCACTGGGCTGCCATTTAGCCATGTGCCATCTCTGAAGTCAGAGGTGTTTGACTCCCA
  TTCCTTGGGCTCTGGAGCTTTCCCCAAGAATTACATCAGAGAAAAGGAAGAAGGGGCCTG
  CAGGACCCATTGGGAATGAGTTTAATACTGAAGTCTGGAATGTAAGCTCATGCCCTAGAG
  GCCTCTCCATATGGCTGGTCAGGGGAGCTGCCTTCAGGCTTGTGCCCCGTGTGCTCAGCA
  GCTGCCTCTGTCCCCCTCTACTGTCCCTTTCACACCTTGCCTGGCCAAGGGGCTAGACCT
  CCCAGGCTAAGCCTCAGATTCAGTGCAGGACACAAGCTCATGCCCCCGTCTTGCCAGTGA
  CACTTGAAGCCTCCCGACTTCCACAGAGTGCTTCAGGACACATTTTGAGTGGTATTTTCT
  TTTCTTTTTTTCTTCTTTTTTTTTTTTTTTTGAGATGGAGTCTCGTTCTGTTGCCCAGGC
  TGGAGTGCAGTGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATT
  CTTCTGCCTCAGCCTCCAGAGTAGCTGGGACTATAGACATGCACCACCACGCCCGGCTAA
  TTTTGTATTTTTGGTCGAGACGGGGTTTTGCCATGTTAGTCAGGCTGGTCTTGAACTCCT
  GACCTCAAGTGATCCACCACCTCGGCCTCCCAAAGTGTTGAGATGACAGGCACGAGCCAC
  CAGGCCCAGCCTGAGTGGTATTTTCTTTAGGGACCAGGTAGACTTTAAAACGAGGGTAAG
  AGAAAAGCCAGTGTCTTTCTGAGGTAAATAATTTCTGCCAGGAAACTTCCCAGCCCCACC
  AGCAGCCACCCTAAAAAAAATCACTCGTGTCCCCAGGGACTTCTAAAGCTTGGGGCTCCA
  GGAAATCATCCAGTAGAGTTGGAGATTCAGAGATTTCTTGAAGCCAGGGACATGCTCCTA
  ACTCCTTTCCCATTAAAGGTGTTAGAATAGACCAGAGGGTGTCCCTTTTCCACAGTAATG
  GGATCGGCTGGTGTGCCTTCAGGGAGGAAGAGGGAGGTGGTCAAGCTTGAAAAACTGGCT
  TTAGGATGGTTCTGACTTTGTTCTCCCTCCCCAAGTGTTCTCAACCTCCATTCTGCAGTG
  TTCAGAGTTTTAGGGAAAGGGTTTGGGTGCCCCAGCATCCAGGTGTTGTGTGGCTTAGCG
  CATGTGAAGTGAAAACCTTCTGGGGTTGTTTGGAAGCAGCTTTCTGGTTCTTGTGATTGT
  ATCCTGAGGTCCCAGAACCCTATTCTCCCACGAGGATCCTCAGTGACCATGGTGGCCACA
  CGCCTGGCCAGCCTGCTGGCTCCTGGGTGAGCTGAAGAACCTTGCCTGTGGCACTTTTCG
  AGGGTGAGCTGGAACCGAGAGAACATGGTCCCCGTGCTGGGACTCATGCGGGTCATTTCC
  TGCCGGCCTGGTTTCGCCTGGTCGTGTCTTTATGAGCACCATGTAAGCCTCCTTGTATTG
  AGATAATTGGGCATTAAACATTAAACTGCAGCTCTGGGAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_004091
• ORF Size: 1314 bp
• Insert Size: 4800
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and the protein assoicated with this clone was found to be identical to protein encoded by NM_004091.2.

Reference Data

• RefSeq: NM_004091.2, NP_004082.1
• RefSeq Size: 5273
• RefSeq ORF: 1314
• Locus ID: 1870
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
• Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]