Integrin alpha 3 (ITGA3) (NM_005501) Human Untagged Clone

CAT#: SC303656

ITGA3 (untagged)-Human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b


  "NM_005501" in other vectors (4)

Reconstitution Protocol

USD 2,160.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ITGA3
Synonyms CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_005501 edited
GAAGCCGGGATCGAAGGCGACAGCGCGGCCAAGGGGGCGCGGCCGGGACAAGCTGGGGGC
CGGTTGCCCGGGGCAGGGACGGCGGCGACCCGGCCGCTGGGGAGGCAGGAAGATAGACCC
ACGGATCTTAGGAAGGGATCCGAGAGCGCAGCTGTGAAACTGGCTGGGGCTGGGGGCACG
AAACCGATCAGCGCTACGGAGCGCAGCGGCCGGCGGGTTCCAGTGTCCTCCGGCGGCGCG
GGGAGCAGGTGAACAGGTCCTCACGCCCAGCTCCGCGCCCTCACGCGCTCTCGCCGGGAC
CCCGCTTCCGCTGGCAGCCATGGGCCCCGGCCCCAGCCGCGCGCCCCGCGCCCCACGCCT
GATGCTCTGTGCGCTCGCCTTGATGGTGGCGGCCGGCGGCTGCGTCGTCTCCGCCTTCAA
CCTGGATACCCGATTCCTGGTAGTGAAGGAGGCCGGGAACCCGGGCAGCCTCTTCGGCTA
CTCGGTCGCCCTCCATCGGCAGACAGAGCGGCAGCAGCGCTACCTGCTCCTGGCTGGTGC
CCCCCGGGAGCTCGCTGTGCCCGATGGCTACACCAACCGGACTGGTGCTGTGTACCTGTG
CCCACTCACTGCCCACAAGGATGACTGTGAGCGGATGAACATCACAGTGAAAAATGACCC
TGGCCATCACATTATTGAGGACATGTGGCTTGGAGTGACTGTGGCCAGCCAGGGCCCTGC
AGGCAGAGTTCTGGTCTGTGCCCACCGCTACACCCAGGTGCTGTGGTCAGGGTCAGAAGA
CCAGCGGCGCATGGTGGGCAAGTGCTACGTGCGAGGCAATGACCTAGAGCTGGACTCCAG
TGATGACTGGCAGACCTACCACAACGAGATGTGCAATAGCAACACAGACTACCTGGAGAC
GGGCATGTGCCAGCTGGGCACCAGCGGTGGCTTCACCCAGAACACTGTGTACTTCGGCGC
CCCCGGTGCCTACAACTGGAAAGGAAACAGCTACATGATTCAGCGCAAGGAGTGGGACTT
ATCTGAGTATAGTTACAAGGACCCAGAGGACCAAGGAAACCTCTATATTGGGTACACGAT
GCAGGTAGGCAGCTTCATCCTGCACCCCAAAAACATCACCATTGTGACAGGTGCCCCACG
GCACCGACATATGGGCGCGGTGTTCTTGCTGAGCCAGGAGGCAGGCGGAGACCTGCGGAG
GAGGCAGGTGCTGGAGGGCTCGCAGGTGGGCGCCTATTTTGGCAGCGCAATTGCCCTGGC
AGACCTGAACAATGATGGGTGGCAGGACCTCCTGGTGGGCGCCCCCTACTACTTCGAGAG
GAAAGAGGAAGTAGGGGGTGCCATCTATGTCTTCATGAACCAGGCGGGAACCTCCTTCCC
TGCTCACCCCTCACTCCTTCTTCATGGCCCCAGTGGCTCTGCCTTTGGTTTATCTGTGGC
CAGCATTGGTGACATCAACCAGGATGGATTTCAGGATATTGCTGTGGGAGCTCCGTTTGA
AGGCTTGGGCAAAGTGTACATCTATCACAGTAGCTCTAAGGGGCTCCTTAGACAGCCCCA
GCAGGTAATCCATGGAGAGAAGCTGGGACTGCCTGGGTTGGCCACCTTCGGCTATTCCCT
CAGTGGGCAGATGGATGTGGATGAGAACTTCTACCCAGACCTTCTAGTGGGAAGCCTGTC
AGACCACATTGTGCTGCTGCGGGCCCGGCCAGTCATCAACATCGTCCACAAGACCTTGGT
GCCCAGGCCAGCTGTGCTGGACCCTGCACTTTGCACGGCCACCTCTTGTGTGCAAGTGGA
GCTGTGCTTTGCTTACAACCAGAGTGCCGGGAACCCCAACTACAGGCGAAACATCACCCT
GGCCTACACTCTGGAGGCTGACAGGGACCGCCGGCCGCCCCGGCTCCGCTTTGCCGGCAG
TGAGTCCGCTGTCTTCCACGGCTTCTTCTCCATGCCCGAGATGCGCTGCCAGAAGCTGGA
GCTGCTCCTGATGGACAACCTCCGTGACAAACTCCGCCCCATCATCATCTCCATGAACTA
CTCTTTACCTTTGCGGATGCCCGATCGCCCCCGGCTGGGGCTGCGGTCCCTGGACGCCTA
CCCGATCCTCAACCAGGCACAGGCTCTGGAGAACCACACTGAGGTCCAGTTCCAGAAGGA
GTGCGGGCCTGACAACAAGTGTGAGAGCAACTTGCAGATGCGGGCAGCCTTCGTGTCAGA
GCAGCAGCAGAAGCTGAGCAGGCTCCAGTACAGCAGAGACGTCCGGAAATTGCTCCTGAG
CATCAACGTGACGAACACCCGGACCTCGGAGCGCTCCGGGGAGGACGCCCACGAGGCGCT
GCTCACCCTGGTGGTGCCTCCCGCCCTGCTGCTGTCCTCAGTGCGCCCCCCCGGGGCCTG
CCAAGCTAATGAGACCATCTTTTGCGAGCTGGGGAACCCCTTCAAACGGAACCAGAGGAT
GGAGCTGCTCATCGCCTTTGAGGTCATCGGGGTGACCCTGCACACAAGGGACCTTCAGGT
GCAGCTGCAGCTCTCCACGTCGAGTCACCAGGACAACCTGTGGCCCATGATCCTCACTCT
GCTGGTGGACTATACACTCCAGACCTCGCTTAGCATGGTAAATCACCGGCTACAAAGCTT
CTTTGGGGGGACAGTGATGGGTGAGTCTGGCATGAAAACTGTGGAGGATGTAGGAAGCCC
CCTCAAGTATGAATTCCAGGTGGGCCCAATGGGGGAGGGGCTGGTGGGCCTGGGGACCCT
GGTCCTAGGTCTGGAGTGGCCCTACGAAGTCAGCAATGGCAAGTGGCTGCTGTATCCCAC
GGAGATCACCGTCCATGGCAATGGGTCCTGGCCCTGCCGACCACCTGGAGACCTTATCAA
CCCTCTCAACCTCACTCTTTCTGACCCTGGGGACAGGCCATCATCCCCACAGCGCAGGCG
GCGACAGCTGGATCCAGGGGGAGGCCAGGGCCCCCCACCTGTCACTCTGGCTGCTGCCAA
AAAAGCCAAGTCTGAGACTGTGCTGACCTGTGCCACAGGGCGTGCCCACTGTGTGTGGCT
AGAGTGCCCCATCCCTGATGCCCCCGTTGTCACCAACGTGACTGTGAAGGCACGAGTGTG
GAACAGCACCTTCATCGAGGATTACAGAGACTTTGACCGAGTCCGGGTAAATGGCTGGGC
TACCCTATTCCTCCGAACCAGCATCCCCACCATCAACATGGAGAACAAGACCACGTGGTT
CTCTGTGGACATTGACTCGGAGCTGGTGGAGGAGCTGCCGGCCGAAATCGAGCTGTGGCT
GGTGCTGGTGGCCGTGGGTGCAGGGCTGCTGCTGCTGGGGCTGATCATCCTCCTGCTGTG
GAAGTGTGACTTCTTTAAGCGGACCCGCTATTATCAGATCATGCCCAAGTACCACGCAGT
GCGGATCCGGGAGGAGGAGCGCTACCCACCTCCAGGGAGCACCCTGCCCACCAAGAAGCA
CTGGGTGACCAGCTGGCAGACTCGGGACCAATACTACTGACGTCCTCCCTGATCCCACCC
CCTCCTCCCCCAGTGTCCCCTTTCTTCCTATTTATCATAAGTTATGCCTCTGACAGTCCA
CAGGGGCCACCACCTTTGGCTGGTAGCAGCAGGCTCAGGCACATACACCTCGTCAAGAGC
ATGCACATGCTGTCTGGCCCTGGGGATCTTCCCACAGGAGGGCCAGCGCTGTGGACCTTA
CAACGCCGAGTGCACTGCATTCCTGTGCCCTAGATGCACGTGGGGCCCACTGCTCGTGGA
CTGTGCTGGTGCATCACGGATGGTGCATGGGCTCGCCGTGTCTCAGCCTCTGCCAGCGCC
AAAACAAGCCAAAGAGCCTCCCACCAGAGCTGGGAGGAAAAGGCCCCTGCAATGTGGTGA
CACCTCCCCTTTCACACCTGGATCCATCTTGAGAGCCACAGTCACTGGATTGACTTTGCT
GTCAAAACTACTGACAGGGAGCAGCCCCCGGGCCGCTGGCTGGTGGGCCCCCAATTGACA
CCCATGCCAGAGAGGTGGGGATCCTGCCTAAGGTTGTCTACGGGGGCACTTGGAGGACCT
GGCGTGCTCAGACCCAACAGCAAAGGAACTAGAAAGAAGGACCCAGAAGGCTTGCTTTCC
TGCATCTCTGTGAAGCCTCTCTCCTTGGCCACAGACTGAACTCGCAGGGAGTGCAGCAGG
AAGGAACAAAGACAGGCAAACGGCAACGTAGCCTGGGCTCACTGTGCTGGGGCATGGCGG
GATCCTCCACAGAGAGGAGGGGACCAATTCTGGACAGACAGATGTTGGGAGGATACAGAG
GAGATGCCACTTCTCACTCACCACTACCAGCCAGCCTCCAGAAGGCCCCAGAGAGACCCT
GCAAGACCACGGAGGGAGCCGACACTTGAATGTAGTAATAGGCAGGGGGTCTTGCCCCAC
CCCATCCAGCCAGACCCCACGCTG:ACCATGCGTCAGGGGCCTAGAGGTGGAGTTCTTAG
CTATCCTTGGCTTTCAGAGCCAGCCTGGTTCTGCCCCCTCCCCCATGGGCTGTGTCTTAA
GGCCCATTTGAGAAGCTGAGGCTAGTTCCAGAAAACCTCTCCTGACCCCTGCCTGTTGGC
AGGCCCACTCCCCAGCCCCAGCCCCTTCCATGGTACTGTAGCAGGGGAATTCCCTCCCCC
TCCTTGTGCCTTCTTTGTATATAGGTTTCTCACGGCGACCAATAAACAGCTCCCAGTTTG
CAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_005501
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005501.1, NP_005492.1
RefSeq Size 4495 bp
RefSeq ORF 3201 bp
Locus ID 3675
Cytogenetics 17q21.33
Protein Families Druggable Genome, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
Gene Summary 'The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]'
Transcript Variant: This variant (b) is missing the penultimate exon found in transcript variant a. This results in a frame-shift and a longer isoform (b) with a distinct C-terminus compared to isoform a.

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