Integrin alpha 3 (ITGA3) (NM_005501) Human Untagged Clone

CAT#: SC303656

ITGA3 (untagged)-Human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ITGA3
• Synonyms: CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005501 edited
  GAAGCCGGGATCGAAGGCGACAGCGCGGCCAAGGGGGCGCGGCCGGGACAAGCTGGGGGC
  CGGTTGCCCGGGGCAGGGACGGCGGCGACCCGGCCGCTGGGGAGGCAGGAAGATAGACCC
  ACGGATCTTAGGAAGGGATCCGAGAGCGCAGCTGTGAAACTGGCTGGGGCTGGGGGCACG
  AAACCGATCAGCGCTACGGAGCGCAGCGGCCGGCGGGTTCCAGTGTCCTCCGGCGGCGCG
  GGGAGCAGGTGAACAGGTCCTCACGCCCAGCTCCGCGCCCTCACGCGCTCTCGCCGGGAC
  CCCGCTTCCGCTGGCAGCCATGGGCCCCGGCCCCAGCCGCGCGCCCCGCGCCCCACGCCT
  GATGCTCTGTGCGCTCGCCTTGATGGTGGCGGCCGGCGGCTGCGTCGTCTCCGCCTTCAA
  CCTGGATACCCGATTCCTGGTAGTGAAGGAGGCCGGGAACCCGGGCAGCCTCTTCGGCTA
  CTCGGTCGCCCTCCATCGGCAGACAGAGCGGCAGCAGCGCTACCTGCTCCTGGCTGGTGC
  CCCCCGGGAGCTCGCTGTGCCCGATGGCTACACCAACCGGACTGGTGCTGTGTACCTGTG
  CCCACTCACTGCCCACAAGGATGACTGTGAGCGGATGAACATCACAGTGAAAAATGACCC
  TGGCCATCACATTATTGAGGACATGTGGCTTGGAGTGACTGTGGCCAGCCAGGGCCCTGC
  AGGCAGAGTTCTGGTCTGTGCCCACCGCTACACCCAGGTGCTGTGGTCAGGGTCAGAAGA
  CCAGCGGCGCATGGTGGGCAAGTGCTACGTGCGAGGCAATGACCTAGAGCTGGACTCCAG
  TGATGACTGGCAGACCTACCACAACGAGATGTGCAATAGCAACACAGACTACCTGGAGAC
  GGGCATGTGCCAGCTGGGCACCAGCGGTGGCTTCACCCAGAACACTGTGTACTTCGGCGC
  CCCCGGTGCCTACAACTGGAAAGGAAACAGCTACATGATTCAGCGCAAGGAGTGGGACTT
  ATCTGAGTATAGTTACAAGGACCCAGAGGACCAAGGAAACCTCTATATTGGGTACACGAT
  GCAGGTAGGCAGCTTCATCCTGCACCCCAAAAACATCACCATTGTGACAGGTGCCCCACG
  GCACCGACATATGGGCGCGGTGTTCTTGCTGAGCCAGGAGGCAGGCGGAGACCTGCGGAG
  GAGGCAGGTGCTGGAGGGCTCGCAGGTGGGCGCCTATTTTGGCAGCGCAATTGCCCTGGC
  AGACCTGAACAATGATGGGTGGCAGGACCTCCTGGTGGGCGCCCCCTACTACTTCGAGAG
  GAAAGAGGAAGTAGGGGGTGCCATCTATGTCTTCATGAACCAGGCGGGAACCTCCTTCCC
  TGCTCACCCCTCACTCCTTCTTCATGGCCCCAGTGGCTCTGCCTTTGGTTTATCTGTGGC
  CAGCATTGGTGACATCAACCAGGATGGATTTCAGGATATTGCTGTGGGAGCTCCGTTTGA
  AGGCTTGGGCAAAGTGTACATCTATCACAGTAGCTCTAAGGGGCTCCTTAGACAGCCCCA
  GCAGGTAATCCATGGAGAGAAGCTGGGACTGCCTGGGTTGGCCACCTTCGGCTATTCCCT
  CAGTGGGCAGATGGATGTGGATGAGAACTTCTACCCAGACCTTCTAGTGGGAAGCCTGTC
  AGACCACATTGTGCTGCTGCGGGCCCGGCCAGTCATCAACATCGTCCACAAGACCTTGGT
  GCCCAGGCCAGCTGTGCTGGACCCTGCACTTTGCACGGCCACCTCTTGTGTGCAAGTGGA
  GCTGTGCTTTGCTTACAACCAGAGTGCCGGGAACCCCAACTACAGGCGAAACATCACCCT
  GGCCTACACTCTGGAGGCTGACAGGGACCGCCGGCCGCCCCGGCTCCGCTTTGCCGGCAG
  TGAGTCCGCTGTCTTCCACGGCTTCTTCTCCATGCCCGAGATGCGCTGCCAGAAGCTGGA
  GCTGCTCCTGATGGACAACCTCCGTGACAAACTCCGCCCCATCATCATCTCCATGAACTA
  CTCTTTACCTTTGCGGATGCCCGATCGCCCCCGGCTGGGGCTGCGGTCCCTGGACGCCTA
  CCCGATCCTCAACCAGGCACAGGCTCTGGAGAACCACACTGAGGTCCAGTTCCAGAAGGA
  GTGCGGGCCTGACAACAAGTGTGAGAGCAACTTGCAGATGCGGGCAGCCTTCGTGTCAGA
  GCAGCAGCAGAAGCTGAGCAGGCTCCAGTACAGCAGAGACGTCCGGAAATTGCTCCTGAG
  CATCAACGTGACGAACACCCGGACCTCGGAGCGCTCCGGGGAGGACGCCCACGAGGCGCT
  GCTCACCCTGGTGGTGCCTCCCGCCCTGCTGCTGTCCTCAGTGCGCCCCCCCGGGGCCTG
  CCAAGCTAATGAGACCATCTTTTGCGAGCTGGGGAACCCCTTCAAACGGAACCAGAGGAT
  GGAGCTGCTCATCGCCTTTGAGGTCATCGGGGTGACCCTGCACACAAGGGACCTTCAGGT
  GCAGCTGCAGCTCTCCACGTCGAGTCACCAGGACAACCTGTGGCCCATGATCCTCACTCT
  GCTGGTGGACTATACACTCCAGACCTCGCTTAGCATGGTAAATCACCGGCTACAAAGCTT
  CTTTGGGGGGACAGTGATGGGTGAGTCTGGCATGAAAACTGTGGAGGATGTAGGAAGCCC
  CCTCAAGTATGAATTCCAGGTGGGCCCAATGGGGGAGGGGCTGGTGGGCCTGGGGACCCT
  GGTCCTAGGTCTGGAGTGGCCCTACGAAGTCAGCAATGGCAAGTGGCTGCTGTATCCCAC
  GGAGATCACCGTCCATGGCAATGGGTCCTGGCCCTGCCGACCACCTGGAGACCTTATCAA
  CCCTCTCAACCTCACTCTTTCTGACCCTGGGGACAGGCCATCATCCCCACAGCGCAGGCG
  GCGACAGCTGGATCCAGGGGGAGGCCAGGGCCCCCCACCTGTCACTCTGGCTGCTGCCAA
  AAAAGCCAAGTCTGAGACTGTGCTGACCTGTGCCACAGGGCGTGCCCACTGTGTGTGGCT
  AGAGTGCCCCATCCCTGATGCCCCCGTTGTCACCAACGTGACTGTGAAGGCACGAGTGTG
  GAACAGCACCTTCATCGAGGATTACAGAGACTTTGACCGAGTCCGGGTAAATGGCTGGGC
  TACCCTATTCCTCCGAACCAGCATCCCCACCATCAACATGGAGAACAAGACCACGTGGTT
  CTCTGTGGACATTGACTCGGAGCTGGTGGAGGAGCTGCCGGCCGAAATCGAGCTGTGGCT
  GGTGCTGGTGGCCGTGGGTGCAGGGCTGCTGCTGCTGGGGCTGATCATCCTCCTGCTGTG
  GAAGTGTGACTTCTTTAAGCGGACCCGCTATTATCAGATCATGCCCAAGTACCACGCAGT
  GCGGATCCGGGAGGAGGAGCGCTACCCACCTCCAGGGAGCACCCTGCCCACCAAGAAGCA
  CTGGGTGACCAGCTGGCAGACTCGGGACCAATACTACTGACGTCCTCCCTGATCCCACCC
  CCTCCTCCCCCAGTGTCCCCTTTCTTCCTATTTATCATAAGTTATGCCTCTGACAGTCCA
  CAGGGGCCACCACCTTTGGCTGGTAGCAGCAGGCTCAGGCACATACACCTCGTCAAGAGC
  ATGCACATGCTGTCTGGCCCTGGGGATCTTCCCACAGGAGGGCCAGCGCTGTGGACCTTA
  CAACGCCGAGTGCACTGCATTCCTGTGCCCTAGATGCACGTGGGGCCCACTGCTCGTGGA
  CTGTGCTGGTGCATCACGGATGGTGCATGGGCTCGCCGTGTCTCAGCCTCTGCCAGCGCC
  AAAACAAGCCAAAGAGCCTCCCACCAGAGCTGGGAGGAAAAGGCCCCTGCAATGTGGTGA
  CACCTCCCCTTTCACACCTGGATCCATCTTGAGAGCCACAGTCACTGGATTGACTTTGCT
  GTCAAAACTACTGACAGGGAGCAGCCCCCGGGCCGCTGGCTGGTGGGCCCCCAATTGACA
  CCCATGCCAGAGAGGTGGGGATCCTGCCTAAGGTTGTCTACGGGGGCACTTGGAGGACCT
  GGCGTGCTCAGACCCAACAGCAAAGGAACTAGAAAGAAGGACCCAGAAGGCTTGCTTTCC
  TGCATCTCTGTGAAGCCTCTCTCCTTGGCCACAGACTGAACTCGCAGGGAGTGCAGCAGG
  AAGGAACAAAGACAGGCAAACGGCAACGTAGCCTGGGCTCACTGTGCTGGGGCATGGCGG
  GATCCTCCACAGAGAGGAGGGGACCAATTCTGGACAGACAGATGTTGGGAGGATACAGAG
  GAGATGCCACTTCTCACTCACCACTACCAGCCAGCCTCCAGAAGGCCCCAGAGAGACCCT
  GCAAGACCACGGAGGGAGCCGACACTTGAATGTAGTAATAGGCAGGGGGTCTTGCCCCAC
  CCCATCCAGCCAGACCCCACGCTG:ACCATGCGTCAGGGGCCTAGAGGTGGAGTTCTTAG
  CTATCCTTGGCTTTCAGAGCCAGCCTGGTTCTGCCCCCTCCCCCATGGGCTGTGTCTTAA
  GGCCCATTTGAGAAGCTGAGGCTAGTTCCAGAAAACCTCTCCTGACCCCTGCCTGTTGGC
  AGGCCCACTCCCCAGCCCCAGCCCCTTCCATGGTACTGTAGCAGGGGAATTCCCTCCCCC
  TCCTTGTGCCTTCTTTGTATATAGGTTTCTCACGGCGACCAATAAACAGCTCCCAGTTTG
  CAAAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_005501
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005501.1, NP_005492.1
• RefSeq Size: 4495 bp
• RefSeq ORF: 3201 bp
• Locus ID: 3675
• Cytogenetics: 17q21.33
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
• Gene Summary: 'The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]'
  Transcript Variant: This variant (b) is missing the penultimate exon found in transcript variant a. This results in a frame-shift and a longer isoform (b) with a distinct C-terminus compared to isoform a.