IL12RB1 (NM_005535) Human Untagged Clone

CAT#: SC303661

IL12RB1 (untagged)-Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1


  "NM_005535" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL12RB1
Synonyms CD212; IL-12R-BETA1; IL12RB; IMD30
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_005535 edited
ACCTCGCAGGTGGCAGAGAGGCTCCCCTGGGGCTGTGGGGCTCTACGTGGATCTGATGGA
GCCGCTGGTGACCTGGGTGGTCCCCCTCCTCTTCCTCTTCCTGCTGTCCAGGCAGGGCGC
TGCCTGCAGAACCAGTGAGTGCTGTTTTCAGGACCCGCCATATCCGGATGCAGACTCAGG
CTCGGCCTCGGGCCCTAGGGACCTGAGATGCTATCGGATATCCAGTGATCGTTACGAGTG
CTCCTGGCAGTATGAGGGTCCCACAGCTGGGGTCAGCCACTTCCTGCGGTGTTGCCTTAG
CTCCGGGCGCTGCTGCTACTTCGCCGCCGGCTCAGCCACCAGGCTGCAGTTCTCCGACCA
GGCTGGGGTGTCTGTGCTGTACACTGTCACACTCTGGGTGGAATCCTGGGCCAGGAACCA
GACAGAGAAGTCTCCTGAGGTCACCCTGCAGCTCTACAACTCAGTTAAATATGAGCCTCC
TCTGGGAGACATCAAGGTGTCCAAGTTGGCCGGGCAGCTGCGTATGGAGTGGGAGACCCC
GGATAACCAGGTTGGTGCTGAGGTGCAGTTCCGGCACCGGACACCCAGCAGCCCATGGAA
GTTGGGCGACTGCGGACCTCAGGATGATGATACTGAGTCCTGCCTCTGCCCCCTGGAGAT
GAATGTGGCCCAGGAATTCCAGCTCCGACGACGGCGGCTGGGGAGCCAAGGAAGTTCCTG
GAGCAAGTGGAGCAGCCCTGTGTGCGTTCCCCCTGAAAACCCCCCACAGCCTCAGGTGAG
ATTCTCGGTGGAGCAGCTGGGCCAGGATGGGAGGAGGCGGCTGACCCTGAAAGAGCAGCC
AACCCAGCTGGAGCTTCCAGAAGGCTGTCAAGGGCTGGCGCCTGGCACGGAGGTCACTTA
CCGACTACAGCTCCACATGCTGTCCTGCCCGTGTAAGGCCAAGGCCACCAGGACCCTGCA
CCTGGGGAAGATGCCCTATCTCTCGGGTGCTGCCTACAACGTGGCTGTCATCTCCTCGAA
CCAATTTGGTCCTGGCCTGAACCAGACGTGGCACATTCCTGCCGACACCCACACAGAACC
AGTGGCTCTGAATATCAGCGTCGGAACCAACGGGACCACCATGTATTGGCCAGCCCGGGC
TCAGAGCATGACGTATTGCATTGAATGGCAGCCTGTGGGCCAGGACGGGGGCCTTGCCAC
CTGCAGCCTGACTGCGCCGCAAGACCCGGATCCGGCTGGAATGGCAACCTACAGCTGGAG
TCGAGAGTCTGGGGCAATGGGGCAGGAAAAGTGTTACTACATTACCATCTTTGCCTCTGC
GCACCCCGAGAAGCTCACCTTGTGGTCTACGGTCCTGTCCACCTACCACTTTGGGGGCAA
TGCCTCAGCAGCTGGGACACCGCACCACGTCTCGGTGAAGAATCATAGCTTGGACTCTGT
GTCTGTGGACTGGGCACCATCCCTGCTGAGCACCTGTCCCGGCGTCCTAAAGGAGTATGT
TGTCCGCTGCCGAGATGAAGACAGCAAACAGGTGTCAGAGCATCCCGTGCAGCCCACAGA
GACCCAAGTTACCCTCAGTGGCCTGCGGGCTGGTGTAGCCTACACGGTGCAGGTGCGAGC
AGACACAGCGTGGCTGAGGGGTGTCTGGAGCCAGCCCCAGCGCTTCAGCATCGAAGTGCA
GGTTTCTGATTGGCTCATCTTCTTCGCCTCCCTGGGGAGCTTCCTGAGCATCCTTCTCGT
GGGCGTCCTTGGCTACCTTGGCCTGAACAGGGCCGCACGGCACCTGTGCCCGCCGCTGCC
CACACCCTGTGCCAGCTCCGCCATTGAGTTCCCTGGAGGGAAGGAGACTTGGCAGTGGAT
CAACCCAGTGGACTTCCAGGAAGAGGCATCCCTGCAGGAGGCCCTGGTGGTAGAGATGTC
CTGGGACAAAGGCGAGAGGACTGAGCCTCTCGAGAAGACAGAGCTACCTGAGGGTGCCCC
TGAGCTGGCCCTGGATACAGAGTTGTCCTTGGAGGATGGAGACAGGTGCAAGGCCAAGAT
GTGATCGTTGAGGCTC
>OriGene 5' read for NM_005535 unedited
GTTCACCATTTGTATACGACTCATATAGGCGGCCGCGNATTCAGATCTGGTACCGAGCTC
GGATCCACTAGTAACGGCCGCCATGTGCTGGAATTCGCCCTTACCTCGCAGGTGGCAGAG
AGGCTCCCCTGGGGCTGTGGGGCTCTACGTGGATCTGATGGAGCCGCTGGTGACCTGGGT
GGTCCCCCTCCTCTTCCTCTTCCTGCTGTCCAGGCAGGGCGCTGCCTGCAGAACCAGTGA
GTGCTGTTTTCAGGACCCGCCATATCCGGATGCAGACTCAGGCTCGGCCTCGGGCCCTAG
GGACCTGAGATGCTATCGGATATCCAGTGATCGTTACGAGTGCTCCTGGCAGTATGAGGG
TCCCACAGCTGGGGTCAGCCACTTCCTGCGGTGTTGCCTTAGCTCCGGGCGCTGCTGCTA
CTTCGCCGCCGGCTCAGCCACCAGGCTGCAGTTCTCCGACCAGGCTGGGGTGTCTGTGCT
GTACACTGTCACACTCTGGGTGGAATCCTGGGCCAGGAACCAGACAGAGAAGTCTCCTGA
GGTCACCCTGCAGCTCTACAACTCAGTTAAATATGAGCCTCCTCTGGGAGACATCAAGGT
GTCCAAGTTGGCCGGGCAGCTGCGTATGGAGTGGGAGACCCCGGATAACCAGGTTGGTGC
TNGAGTGCAGTTCCGGCACCGGACACCCAGCAGCCCATGGAAGTTGGGCGACTGCGGACC
TCANGATGATGATACTGAGTCCTGCCTCTGCCCCCTGGAGATGAATGTGGCCCCAAGAAT
TCCAGCTCCGACGACGGCGGCTGGGGAGCCAAGGGAAGTCCTGGAGCAA
>OriGene 3' read for NM_005535 unedited
CATTGGNGATGGCAACTTCCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCC
ACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATGCATGCTCGAG
CGGCCGCCAGTGTGATGGATATCTGCAGAATTCGCCCTTGAGCCTCAACGATCACATCTT
GGCCTTGCACCTGTCTCCATCCTCCAAGGACAACTCTGTATCCAGGGCCAGCTCAGGGGC
ACCCTCAGGTAGCTCTGTCTTCTCGAGAGGCTCAGTCCTCTCGCCTTTGTCCCAGGACAT
CTCTACCACCAGGGCCTCCTGCAGGGATGCCTCTTCCTGGAAGTCCACTGGGTTGATCCA
CTGCCAAGTCTCCTTCCCTCCAGGGAACTCAATGGCGGAGCTGGCACAGGGTGTGGGCAG
CGGCGGGCACAGGTGCCGTGCGGCCCTGTTCAGGCCAAGGTAGCCAAGGACGCCCACGAG
AAGGATGCTCAGGAAGCTCCCCAGGGAGGCGAAGAAGATGAGCCAATCAGAAACCTGCAC
TTCGATGCTGAAGCGCTGGGGCTGGCTCCAGACACCCCTCAGCCACGCTGTGTCTGCTCG
CACCTGCACCGTGTAGGCTACACCAGCCCCGCAGCCACTGAGGGTAACTTGNGTCTCTGT
GGGCTGCACGGGATGCTCTGACACCTGTTTGCTGTCTTCATCTCGGCAGCGGACAACATA
CTCCTTATAGACGCCGGGACAGGTGCTCAACAGGGATGGTGCCCCAGTCCACAGACACAG
AGTCCAAGCTATGATTCCTTCACCGAGACGTGGTGCGGTGTCCCAGCTGCTGAGGCATTT
GCCCCCAAAGTGTAAGTGGAACCGGACC
Restriction Sites Please inquire     
ACCN NM_005535
Insert Size 2100 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acid.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005535.1, NP_005526.1
RefSeq Size 2100 bp
RefSeq ORF 1989 bp
Locus ID 3594
Cytogenetics 19p13.11
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Gene Summary 'The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]'
Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR and uses a downstream start codon compared to variant 4. The encoded isoform (1, also known as Long) has a shorter N-terminus compared to isoform 4. Sequence Note: The 5' UTR was inferred from partial sequence data.

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