CLDN16 (NM_006580) Human Untagged Clone

CAT#: SC303793

CLDN16 (untagged)-Human claudin 16 (CLDN16)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLDN16
• Synonyms: HOMG3; PCLN1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006580 edited
  CCCCACCCGAAACACACTCAGCCCTTGCACTGACCTGCCTTCTGATTGGAGGCTGGTTGC
  TTCGGATAATGACCTCCAGGACCCCACTGTTGGTTACAGCCTGTTTGTATTATTCTTACT
  GCAACTCAAGACACCTGCAGCAGGGCGTGAGAAAAAGTAAAAGACCAGTATTTTCACATT
  GCCAGGTACCAGAAACACAGAAGACTGACACCCGCCACTTAAGTGGGGCCAGGGCTGGTG
  TCTGCCCATGTTGCCATCCTGATGGGCTGCTTGCCACAATGAGGGATCTTCTTCAATACA
  TCGCTTGCTTCTTTGCCTTTTTCTCTGCTGGGTTTTTGATTGTGGCCACCTGGACTGACT
  GTTGGATGGTGAATGCTGATGACTCTCTGGAGGTGAGCACAAAATGCCGAGGCCTCTGGT
  GGGAATGCGTCACAAATGCTTTTGATGGGATTCGCACCTGTGATGAGTACGATTCCATAC
  TTGCGGAGCATCCCTTGAAGCTGGTGGTAACTCGAGCGTTGATGATTACTGCAGATATTC
  TAGCTGGGTTTGGATTTCTCACCCTGCTCCTTGGTCTTGACTGCGTGAAATTCCTCCCTG
  ATGAGCCGTACATTAAAGTCCGCATCTGCTTTGTTGCTGGAGCCACGTTACTAATAGCAG
  GTACCCCAGGAATCATTGGCTCTGTGTGGTATGCTGTTGATGTGTATGTGGAACGTTCTA
  CTTTGGTTTTGCACAATATATTTCTTGGTATCCAATATAAATTTGGTTGGTCCTGTTGGC
  TCGGAATGGCTGGGTCTCTGGGTTGCTTTTTGGCTGGAGCTGTTCTCACCTGCTGCTTAT
  ATCTTTTTAAAGATGTTGGACCTGAGAGAAACTATCCTTATTCCTTGAGGAAAGCCTATT
  CAGCCGCGGGTGTTTCCATGGCCAAGTCATACTCAGCCCCTCGCACAGAGACGGCCAAAA
  TGTATGCTGTAGACACAAGGGTGTAAAATGCACGTTTCAGGGTGTGTTTGCATATGATTT
  AATCAATCAGTATGGTTACATTGATAAAATAGTAAGTCAATCCAGGAACAGTTATTTAGA
  ATTCATATTGAATTAAATTAATTGCTAGCTTAATCAAAATGTTTGATTCTCCTATACTTT
  TTCTTTCTATTACTCTTATATTTTCCCGTCATTCTCTCTGCTAACCTTCCACCTTATGCA
  CACACTTTCCCTATATTTTAAGATAAGTCTGCTAGGATGTAGAAATATTTGTTTGTGATT
  TCTATATAGCTATTAGAGATTATGACATAGTAATATTAAAATGAAATGATACTTAAACAG
  AAAGCAATTTCCAAAGAGGCCAGGGACCCTAATCTTTGAAGAGATGAAGAAACTTACTTT
  TCTCCCTGGCTTTTGGTTCACTTTTTGTA
  
• Restriction Sites: Please inquire
• ACCN: NM_006580
• ORF Size: 918 bp
• Insert Size: 1400
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_006580.2.

Reference Data

• RefSeq: NM_006580.2, NP_006571.1
• RefSeq Size: 1494
• RefSeq ORF: 918
• Locus ID: 10686
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
• Gene Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]