UGT2A1 (NM_006798) Human Untagged Clone

CAT#: SC303829

UGT2A1 (untagged)-Human UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus (UGT2A1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UGT2A1
• Synonyms: UDPGT2A1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006798, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGTGGGAATGTTT
  TGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATAGATGAGCTCATTAAAAAGGA
  GCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTCATCACACCAACCTCTAACCCATCTCTGACA
  TTTGAAATATATAAGGTGCCCTTTGGCAAAGAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTTGACAT
  GGCTGGAAAATAGACCATCTCCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGA
  CTTCCACATGGTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
  AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCTTTAAAACTTG
  GAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAAAAGCACTGTGGGAAGGTACC
  ATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTCACCGACCAAATGTCTTTCACTGACAGAATA
  AGAAATTTCATCTCCTACCACCTACAGGACTACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACT
  ATAGTAAAGCTTTAGGAAGACCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCG
  AACATATTGGGATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
  AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAATGGTGTTGTGG
  TGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAATCTTATTGCCTCAGCCCTTGC
  CCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAGAAACCAGCCACATTAGGAAACAATACTCAG
  CTCTTTGATTGGATACCCCAGAATGATCTTCTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTG
  GAACTAATGGGATCTACGAAGCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCA
  GCCTGATAACATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
  GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCTATGAGGTTAT
  CAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCG
  CCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGACCTCACCTGGTTCCAGTACCACTCTTTGGAT
  GTAATTGGGTTCTTGCTGGTCTGTGTGACAACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCT
  GTCAAAAATTTGGTAAGATAGGAAAGAAGAAAAAAAGAGAATAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_006798
• ORF Size: 1584 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006798.4, NP_006789.3
• RefSeq Size: 2655
• RefSeq ORF: 1584
• Locus ID: 10941
• Protein Families: Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• Gene Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]
  Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region, but contains an additional in-frame exon in the 3' coding region, compared to variant 2. The encoded isoform (1, also known as UGT2A1_i1) is shorter than isoform 2.