KIR2DS3 (NM_012313) Human Untagged Clone

CAT#: SC303957

KIR2DS3 (untagged)-Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KIR2DS3
• Synonyms: NKAT7
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_012313 edited
  CCATGTCGCTCATGGTCATCAGCATGGCATGTGTTGGGTTCTTCTGGCTGCAGGGGGCCT
  GGCCACATGAGGGATTCCGCAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGA
  AATCAGAAGAGACAGTCATCCTGCAATGTTGGTCAGATGTCATGTTTGAGCACTTCCTTC
  TGCACAGAGAGGGGACGTTTAACGACACTTTGCGCCTCATTGGAGAGCACATTGATGGGG
  TCTCCAAGGCCAACTTCTCCATCGGTCGCATGAGGCAAGACCTGGCAGGGACCTACAGAT
  GCTACGGTTCTGTTCCTCACTCCCCCTATCAGTTTTCAGCTCCCAGTGACCCTCTGGACA
  TCGTGATCACAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCCGGGCCCCACGGTTC
  TGGCAGGAGAGAGCGTGACCTTGTCCTGCAGCTCCTGGAGCTCCTATGACATGTACCATC
  TATCCACGGAGGGGGAGGCCCATGAACGTAGGTTCTCTGCAGGGCCCAAGGTCAACGGAA
  CATTCCAGGCCGACTTTCCTCTGGGCCCTGCCACCCAAGGAGGAACCTACAGATGCTTCG
  GCTCTTTCCATGACTCTCCCTACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTG
  TCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGGTA
  ACCCCAGACACCTACACGTTCTGATTGGGACCTCAGTGGTCAAACTCCCTTTCACCATCC
  TCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCGACAAAAAAAATGCATCTGTAATGGACC
  AAGGGCCTGCGGGGAACAGAACAGTGAACAGGGAGGATTCTGACGAACAGGACCATCAGG
  AGGTGTCATACGCATAATTGGATCACTGTGTTTTCACACAGAGAAAAATCACTCCCCCTT
  CTCAGAGGCCCAAGACACCCCCAACAGATAGCAGCATGTACATAGAACTTCCAAATGCTG
  AGTCCAGATCCAAAGCTGTCTTCTGTCCACGAGCACCACAGTCAGGCCTTGAGGGGATCT
  TCTAGGGAGTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCCGG
  GTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTTGCCACTCCAGT
  GCCCACCAGCCTTGTCCTAATAAAATTAAGTTGCATCATTTTGTCTGACTAGGTGTCCTT
  CTATAATATTATGGGGTGGAGGG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012313 unedited
  CNCACTATAGGGNNCGGCCGCGNAACTCACCATGTTCGCTCATGGTCATCAGCATGGCAT
  GTGTTGGGTTCTTCTGGCTGCAGGGGGCCTGGCCACATGAGGGATTCCGCAGAAAACCTT
  CCCTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAATGTT
  GGTCAGATGTCATGTTTGAGCACTTCCTTCTGCACAGAGAGGGGACGTTTAACGACACTT
  TGCGCCTCATTGGAGAGCACATTGATGGGGTCTCCAAGGCCAACTTCTCCATCGGTCGCA
  TGAGGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTCCTCACTCCCCCTATC
  AGTTTTCAGCTCCCAGTGACCCTCTGGACATCGTGATCACAGGTCTATATGAGAAACCTT
  CTCTCTCAGCCCAGCCGGGCCCCACGGTTCTGGCAGGAGAGAGCGTGACCTTGTCCTGCA
  GCTCCTGGAGCTCCTATGACATGTACCATCTATCCACGGAGGGGGAGGCCCATGAACGTA
  GGTTCTCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCCGACTTTCCTCTGGGCCCTG
  CCACCCAAGGAGGAACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCCTACGAGTGGT
  CAAAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCANATAGTTGGCCTT
  CACCCACTGAACCAAGCTCCAAAACCGGTAACCCCAGACACCTACACGTTCTGATTGNGA
  CCTCAGTGGTCAAACTCCCTTTCACCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCT
  CCGACAAAAAAATGCATCTGTNATGGACCAAGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_012313 unedited
  AGNAAAGCACTGGGGNAGGGTCACAGGNATGCCACCCGGGATCTGTTCAGGAAACAGCTA
  TGACCGCGGCCGCAATCTAGAGTCGACTCCCTAGAAGATCCCCTCAAGGCCTGACTGTGG
  TGCTCGTGGACAGAAGACAGCTTTGGATCTGGACTCAGCATTTGGAAGTTCTATGTACAT
  GCTGCTATCTGTTGGGGGTGTCTTGGGCCTCTGAGAAGGGGGAGTGATTTTTCTCTGTGT
  GAAAACACAGTGATCCAATTATGCGTATGACACCTCCTGATGGTCCTGTTCGTCAGAATC
  CTCCCTGTTCACTGTTCTGTTCCCCGCAGGCCCTTGGTCCATTACAGATGCATTTTTTTT
  GTCGGAGCACCAGCGATGAAGGAGAAAGAAGAGGAGGATGGTGAAAGGGAGTTTGACCAC
  TGAGGTCCCAATCAGAACGTGTAGGTGTCTGGGGTTACCGGTTTTGGAGCTTGGTTCAGT
  GGGTGAAGGCCAACTATTTGAAGGGTTTCCTGTGACAGAAACAAGCAGTGGGTCACTTGA
  CTTTGACCACTCGTAGGGAGAGTCATGGAAAGAGCCGAAGCATCTGTAGGTTCCTCNCTT
  GGTGGCAGGGCCCAGAGGAAAGTCGGCCTGGAATGTTCCGTTGACCTTGGGCCCTGCAGA
  GAACCTACGTTCATGGGCCTCCCCCTCCGTGGATAGATGGTACATGTCATAAGAGCTCCA
  GGAGCTGCAGGACAAGGTCACGCTCTCTCCTGCCAGAACCGTGGGGCCCGGCTGGGCTGA
  GAGAAAGGTTTCTCATATAGACCTGTGATCACGATGTCCAGAGGGTCACTGGGAGCTGAA
  AACTGATAGGGGGAGTGAGG
  
• Restriction Sites: Please inquire
• ACCN: NM_012313
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_012313.1, NP_036445.1
• RefSeq Size: 1113 bp
• RefSeq ORF: 915 bp
• Locus ID: 3808
• Cytogenetics: 19q13.4
• Protein Families: Transmembrane
• Protein Pathways: Antigen processing and presentation, Natural killer cell mediated cytotoxicity
• Gene Summary: 'Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]'